Patents by Inventor Weiya Bai

Weiya Bai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA ADENO-ASSOCIATED VIRUS (RAAV) VECTOR AND USES THEREOF
    Publication number: 20240368629
    Abstract: The invention described herein provides a recombinant DNA viral particle comprising a protein shell encapsulating an RNA vector genome, as well as related compositions and uses thereof.
    Type: Application
    Filed: May 15, 2024
    Publication date: November 7, 2024
    Inventors: Linyu Shi, Weiya Bai
  • Cell-Penetrating Peptides and Methods of Use Thereof
    Publication number: 20240368229
    Abstract: In various aspects and embodiments the invention provides compositions and methods for facilitating cell penetration of a cargo molecule. In another aspect, the invention provides a method of preventing viral infection in a subject in need thereof, the method comprising providing to the subject a therapeutically effective amount of a polypeptide comprising a cell-penetrating peptide and a retromer binding site.
    Type: Application
    Filed: June 27, 2024
    Publication date: November 7, 2024
    Inventors: Daniel DiMaio, Pengwei Zhang, Gabriel Monteiro Da Silva, Weiya Bai
  • Cell-penetrating peptides and methods of use thereof
    Patent number: 12060388
    Abstract: In various aspects and embodiments the invention provides compositions and methods for facilitating cell penetration of a cargo molecule. In another aspect, the invention provides a method of preventing viral infection in a subject in need thereof, the method comprising providing to the subject a therapeutically effective amount of a polypeptide comprising a cell-penetrating peptide and a retromer binding site.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: August 13, 2024
    Assignee: YALE UNIVERSITY
    Inventors: Daniel DiMaio, Pengwei Zhang, Gabriel Monteiro Da Silva, Weiya Bai
  • RNA adeno-associated virus (RAAV) vector and uses thereof
    Patent number: 12031148
    Abstract: The invention described herein provides a recombinant DNA viral particle comprising a protein shell encapsulating an RNA vector genome, as well as related compositions and uses thereof.
    Type: Grant
    Filed: June 9, 2022
    Date of Patent: July 9, 2024
    Assignee: HUIDAGENE THERAPEUTICS (SINGAPORE) PTE. LTD.
    Inventors: Linyu Shi, Weiya Bai
  • ADENO-ASSOCIATED VIRUS VECTOR AND USE THEREOF
    Publication number: 20230212605
    Abstract: Provided are an AAV capsid protein mutant and an encoding nucleic acid, and a corresponding vector and a host cell thereof. Also provided are an adeno-associated virus vector containing the AAV capsid protein mutant, a recombinant adeno-associated virus particle constructed therefrom and carrying a gene expression cassette, a preparation method therefor, and the use thereof in treating diseases.
    Type: Application
    Filed: February 4, 2021
    Publication date: July 6, 2023
    Inventors: Xuan Yao, Linyu Shi, Shaoran Wang, Weiya Bai
  • RNA ADENO-ASSOCIATED VIRUS (RAAV) VECTOR AND USES THEREOF
    Publication number: 20230062529
    Abstract: The invention described herein provides a recombinant DNA viral particle comprising a protein shell encapsulating an RNA vector genome, as well as related compositions and uses thereof.
    Type: Application
    Filed: June 9, 2022
    Publication date: March 2, 2023
    Inventors: Linyu Shi, Weiya Bai
  • Cell-Penetrating Peptides and Methods of Use Thereof
    Publication number: 20210206811
    Abstract: In various aspects and embodiments the invention provides compositions and methods for facilitating cell penetration of a cargo molecule. In another aspect, the invention provides a method of preventing viral infection in a subject in need thereof, the method comprising providing to the subject a therapeutically effective amount of a polypeptide comprising a cell-penetrating peptide and a retromer binding site.
    Type: Application
    Filed: May 24, 2019
    Publication date: July 8, 2021
    Inventors: Daniel DiMaio, Pengwei Zhang, Gabriel Monteiro Da Silva, Weiya Bai