Patents by Inventor Weiying Zhao
Weiying Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11446501Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.Type: GrantFiled: June 2, 2020Date of Patent: September 20, 2022Assignee: Cardiac Pacemakers, Inc.Inventors: Weiying Zhao, Quan Ni, Stephen B. Ruble, Jason J. Hamann
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Publication number: 20200289823Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.Type: ApplicationFiled: June 2, 2020Publication date: September 17, 2020Inventors: Weiying Zhao, Quan Ni, Stephen B. Ruble, Jason J. Hamann
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Patent number: 10748659Abstract: Assessing a risk associated with implantation of a drug delivery device configured to treat blood vessels, is described. Particularly, devices, methods, and systems for assessing the risk of stent thrombosis, prior to implantation, for determining the appropriate stent and/or medication regimen for a particular patient, and continuing to assess the risk of stent thrombosis after implantation, thereby improving the efficacy of the therapy, are described. Other embodiments are described and claimed.Type: GrantFiled: March 10, 2015Date of Patent: August 18, 2020Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: Weiying Zhao, Dong Li
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Patent number: 10702698Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.Type: GrantFiled: December 21, 2017Date of Patent: July 7, 2020Assignee: Cardiac Pacemakers, Inc.Inventors: Weiying Zhao, Quan Ni, Stephen B. Ruble, Jason J. Hamann
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Patent number: 10010655Abstract: A drug delivery device for reducing the likelihood of stent thrombosis following implantation in a subject is provided. A stent is provided including a body having a plurality of struts and one or more coatings applied to the body including at least one polymer, a therapeutic agent for inhibiting restenosis, a loading dose of a first antiplatelet agent and a maintenance dose of the first antiplatelet agent, and a loading dose of a second antiplatelet agent and a maintenance dose of the second antiplatelet agent.Type: GrantFiled: March 15, 2013Date of Patent: July 3, 2018Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventor: Weiying Zhao
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Publication number: 20180110988Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.Type: ApplicationFiled: December 21, 2017Publication date: April 26, 2018Inventors: Weiying Zhao, Quan Ni, Stephen B Ruble, Jason J. Hamann
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Patent number: 9849290Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.Type: GrantFiled: September 28, 2016Date of Patent: December 26, 2017Assignee: Cardiac Pacemakers, Inc.Inventors: Weiying Zhao, Quan Ni, Stephen B. Ruble, Jason J. Hamann
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Publication number: 20170036027Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.Type: ApplicationFiled: September 28, 2016Publication date: February 9, 2017Inventors: Weiying Zhao, Quan Ni, Stephen B. Ruble, Jason J. Hamann
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Patent number: 9457187Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.Type: GrantFiled: June 18, 2015Date of Patent: October 4, 2016Assignee: Cardiac Pacemakers, Inc.Inventors: Weiying Zhao, Quan Ni, Stephen B. Ruble, Jason J. Hamann
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Publication number: 20160267243Abstract: The disclosed subject matter relates to assessing the risk associated with implantation of a drug delivery device configured to treat blood vessels. Particularly, the present disclosed subject matter is directed to devices, methods, and systems for assessing the risk of stent thrombosis, prior to implantation, for determining the appropriate stent and/or medication regimen for a particular patient, and continuing to assess the risk of stent thrombosis after implantation, thereby improving the efficacy of the therapy.Type: ApplicationFiled: March 10, 2015Publication date: September 15, 2016Inventors: Weiying Zhao, Dong Li
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Publication number: 20160129243Abstract: Various system embodiments comprise a lead having a distal end and a proximal end. The distal end includes a plurality of electrodes. The lead is configured to be fed into a dorsal epidural space of a human to a desired region of a spinal column and to be fed laterally to at least partially encircle a spinal cord in the desired region to place at least one stimulation electrode in position to stimulate a dorsal nerve root and at least another stimulation electrode in position to stimulate a ventral nerve root. The desired region may include cervical vertebrae, thoracic vertebrae, or lumbar vertebrae. Some embodiments stimulate the spinal cord in the T1-T5 region.Type: ApplicationFiled: January 7, 2016Publication date: May 12, 2016Inventors: Weiying Zhao, Stephen B. Ruble, Allan C. Shuros, Jason J. Hamann
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Patent number: 9259575Abstract: Various system embodiments comprise an implantable lead, an implantable housing, a neural stimulation circuit in the housing, and a controller in the housing and connected to the neural stimulation circuit. The lead has a proximal end and a distal end. The distal end is adapted to deliver neural stimulation pulses to the ventral nerve root and the dorsal nerve root. The proximal end of the lead is adapted to connect to the housing. The neural stimulation circuit is adapted to generate neural stimulation pulses to stimulate the ventral nerve root or the dorsal nerve root using the implantable lead. The controller is adapted to control the neural stimulation circuit to deliver a neural stimulation treatment.Type: GrantFiled: January 10, 2013Date of Patent: February 16, 2016Assignee: Cardiac Pacemakers, Inc.Inventors: Weiying Zhao, Stephen Ruble, Allan C. Shuros, Jason J. Hamann
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Patent number: 9259568Abstract: Various system embodiments comprise a lead having a distal end and a proximal end. The distal end includes a plurality of electrodes. The lead is configured to be fed into a dorsal epidural space of a human to a desired region of a spinal column and to be fed laterally to at least partially encircle a spinal cord in the desired region to place at least one stimulation electrode in position to stimulate a dorsal nerve root and at least another stimulation electrode in position to stimulate a ventral nerve root. The desired region may include cervical vertebrae, thoracic vertebrae, or lumbar vertebrae. Some embodiments stimulate the spinal cord in the T1-T5 region.Type: GrantFiled: April 28, 2009Date of Patent: February 16, 2016Assignee: Cardiac Pacemakers, Inc.Inventors: Weiying Zhao, Stephen Ruble, Allan C. Shuros, Jason J. Hamann
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Publication number: 20150283380Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.Type: ApplicationFiled: June 18, 2015Publication date: October 8, 2015Inventors: Weiying Zhao, Quan Ni, Stephen B. Ruble, Jason J. Hamann
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Patent number: 9061136Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.Type: GrantFiled: January 9, 2014Date of Patent: June 23, 2015Assignee: Cardiac Pacemakers, Inc.Inventors: Weiying Zhao, Quan Ni, Stephen B. Ruble, Jason J. Hamann
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Patent number: 9002448Abstract: Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.Type: GrantFiled: June 3, 2013Date of Patent: April 7, 2015Assignee: Cardiac Pacemakers, Inc.Inventors: Imad Libbus, Andrew P. Kramer, Anthony V. Caparso, Kristofer J. James, Stephen Ruble, Weiying Zhao
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Publication number: 20140277343Abstract: A drug delivery device for reducing the likelihood of stent thrombosis following implantation in a subject is provided. A stent is provided including a body having a plurality of struts and one or more coatings applied to the body including at least one polymer, a therapeutic agent for inhibiting restenosis, a loading dose of a first antiplatelet agent and a maintenance dose of the first antiplatelet agent, and a loading dose of a second antiplatelet agent and a maintenance dose of the second antiplatelet agent.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventor: Weiying Zhao
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Publication number: 20140128953Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.Type: ApplicationFiled: January 9, 2014Publication date: May 8, 2014Applicant: Cardiac Pacemakers, Inc.Inventors: Weiying Zhao, Quan Ni, Stephen B. Ruble, Jason J. Hamann
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Patent number: 8630707Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.Type: GrantFiled: March 12, 2013Date of Patent: January 14, 2014Assignee: Cardiac Pacemakers, Inc.Inventors: Weiying Zhao, Quan Ni, Stephen Ruble, Jason J. Hamann
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Publication number: 20130261691Abstract: Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.Type: ApplicationFiled: June 3, 2013Publication date: October 3, 2013Inventors: Imad Libbus, Andrew P. Kramer, Anthony V. Caparso, Kristofer J. James, Stephen Ruble, Weiying Zhao