Patents by Inventor Weiyong KONG

Weiyong KONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of 5-bromo-2,6-di(1H-pyrazol-1- yl)pyrimidin-4-amine and new salts
    Patent number: 11654144
    Abstract: This application relates to various crystalline forms of 5-bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine and salt thereof, as well as compositions and methods of using the same. In some embodiments the crystalline forms also contain water (“hydrates”). These materials are useful in the treatment of various diseases, including carcinomas, specifically lung cancer and more specifically non-small cell lung cancer.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: May 23, 2023
    Assignees: Novartis AG, Palobiofarma S.L.
    Inventors: Kai Cui, Julio Cesar Castro-Palomino Laria, Weiyong Kong
  • Chemical process for preparing phenylpiperidinyl indole derivatives
    Patent number: 11578053
    Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 9, 2021
    Date of Patent: February 14, 2023
    Assignee: Novartis AG
    Inventors: Peng Fu, Yu Gai, Feng Gao, Weiyong Kong, Yadong Lu, Zhongcheng Min, Shaofeng Rong, Chutian Shu, Can Wang, Ruidong Wang, Jibin Zhao, Xianglin Zhao, Yi Zhao, Jianguang Zhou, Benjamin Martin
  • CHEMICAL PROCESS FOR PREPARING PHENYLPIPERIDINYL INDOLE DERIVATIVES
    Publication number: 20220169630
    Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 9, 2021
    Publication date: June 2, 2022
    Inventors: Peng FU, Yu GAI, Feng GAO, Weiyong KONG, Yadong LU, Zhongcheng MIN, Shaofeng RONG, Chutian SHU, Can WANG, Ruidong WANG, Jibin ZHAO, Xianglin ZHAO, Yi ZHAO, Jianguang ZHOU, Benjamin MARTIN
  • Enzymatic reaction medium containing surfactant
    Patent number: 11220681
    Abstract: The present invention is directed to aqueous reaction mixtures for enzymatic synthesis reactions comprising a surfactant. The surfactant in the reaction mixture increases stability and yield of the enzymatic reaction. Furthermore, method for performing an enzymatic reaction using said aqueous reaction mixtures are provided.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: January 11, 2022
    Assignee: NOVARTIS AG
    Inventors: Yu Gai, Fabrice Gallou, Feng Gao, Pengfei Guo, Weiyong Kong, Michael Parmentier, Jianguang Zhou
  • Chemical process for preparing phenylpiperidinyl indole derivatives
    Patent number: 11208398
    Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: December 28, 2021
    Assignee: NOVARTIS AG
    Inventors: Peng Fu, Yu Gai, Feng Gao, Weiyong Kong, Yadong Lu, Zhongcheng Min, Shaofeng Rong, Chutian Shu, Can Wang, Ruidong Wang, Jibin Zhao, Xianglin Zhao, Yi Zhao, Jianguang Zhou, Benjamin Martin
  • CHEMICAL PROCESS FOR PREPARING PHENYLPIPERIDINYL INDOLE DERIVATIVES
    Publication number: 20210269416
    Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1/-/-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 15, 2019
    Publication date: September 2, 2021
    Inventors: Peng FU, Yu GAI, Feng GAO, Weiyong KONG, Yadong LU, Zhongcheng MIN, Shaofeng RONG, Chutian SHU, Can WANG, Ruidong WANG, Jibin ZHAO, Xianglin ZHAO, Yi ZHAO, Jianguang ZHOU, Benjamin MARTIN
  • CRYSTALLINE FORMS OF 5-BROMO-2,6-DI(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE AND NEW SALTS
    Publication number: 20210145831
    Abstract: This application relates to various crystalline forms of 5-bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine and salt thereof, as well as compositions and methods of using the same. In some embodiments the crystalline forms also contain water (“hydrates”). These materials are useful in the treatment of various diseases, including carcinomas, specifically lung cancer and more specifically non-small cell lung cancer.
    Type: Application
    Filed: January 25, 2021
    Publication date: May 20, 2021
    Inventors: Kai CUI, Julio Cesar CASTRO-PALOMINO LARIA, Weiyong KONG
  • Crystalline forms of 5-bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine and new salts
    Patent number: 10933064
    Abstract: This application relates to various crystalline forms of 5-bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine and salt thereof, as well as compositions and methods of using the same. In some embodiments the crystalline forms also contain water (“hydrates”). These materials are useful in the treatment of various diseases, including carcinomas, specifically lung cancer and more specifically non-small cell lung cancer.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: March 2, 2021
    Assignees: Novartis AG, Palobiofarma S.L.
    Inventors: Kai Cui, Julio Cesar Castro-Palomino Laria, Weiyong Kong
  • CRYSTALLINE FORMS OF 5-BROMO-2,6-DI(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE AND NEW SALTS
    Publication number: 20200163963
    Abstract: This application relates to various crystalline forms of 5-bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine and salt thereof, as well as compositions and methods of using the same. In some embodiments the crystalline forms also contain water (“hydrates”). These materials are useful in the treatment of various diseases, including carcinomas, specifically lung cancer and more specifically non-small cell lung cancer.
    Type: Application
    Filed: May 30, 2018
    Publication date: May 28, 2020
    Inventors: Kai CUI, Julio Cesar CASTRO-PALOMINO LARIA, Weiyong KONG
  • ENZYMATIC REACTION MEDIUM CONTAINING SURFACTANT
    Publication number: 20190367900
    Abstract: The present invention is directed to aqueous reaction mixtures for enzymatic synthesis reactions comprising a surfactant. The surfactant in the reaction mixture increases stability and yield of the enzymatic reaction. Furthermore, method for performing an enzymatic reaction using said aqueous reaction mixtures are provided.
    Type: Application
    Filed: January 11, 2018
    Publication date: December 5, 2019
    Inventors: Yu GAI, Fabrice GALLOU, Feng GAO, Pengfei GUO, Weiyong KONG, Michael PARMENTIER, Jianguang ZHOU