Patents by Inventor Weiyu Lu

Weiyu Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11826431
    Abstract: The present disclosure belongs to the field of pharmaceutical preparations and relates to the design of a series of lipophilic derivatives by using wild-type penetrating peptide penetratin. These penetratin derivatives have a strong ability to penetrate the ocular tissues and do not cause ocular tissue toxicity. As ocular absorption enhancers, non-invasive routes could be used to achieve intraocular drug delivery and increase the ocular bioavailability of drugs. These penetratin derivatives and the ophthalmic drug delivery system constructed by them are used for eye drop administration, which could replace the intraocular injection with poor patients compliance, which greatly enhances the convenience and safety of the treatment of intraocular and fundus diseases.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: November 28, 2023
    Assignee: FUDAN UNIVERSITY
    Inventors: Gang Wei, Kuan Jiang, Weiyue Lu, Chang Liu, Lingyu Tai, Xin Gao
  • Patent number: 11622990
    Abstract: Provided in the present invention are highly stable D-configuration polypeptides DVAP and SVAP having a high binding activity to the GRP78 protein, and also provided are an L-configuration polypeptide LVAP and a DVAP-or SVAP-modified model drug and a macromolecule carrier material, and the use thereof in the construction of a tumour image and a drug-delivery system for targeted treatment.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: April 11, 2023
    Assignee: FUDAN UNIVERSITY
    Inventors: Weiyue Lu, Danni Ran, Jiani Mao, Cao Xie
  • Patent number: 11260032
    Abstract: A nano drug delivery system includes a biofilm-coated drug nanocrystal. A drug in a physical form of nanocrystal is directly used as a rigid supporting skeleton, and is filled in a biofilm. The nano drug delivery system has the advantages of high drug loading capacity, good biocompatibility, long systemic circulation time and drug sustained release.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: March 1, 2022
    Assignee: Shanghai Whittlong Pharmaceutical Institute
    Inventors: Weiyue Lu, Zhilan Chai, Xuefeng Hu, Cao Xie, Huimin Hou, Hao Wang
  • Publication number: 20220008546
    Abstract: The present disclosure belongs to the field of pharmaceutical preparations and relates to the design of a series of lipophilic derivatives by using wild-type penetrating peptide penetratin. These penetratin derivatives have a strong ability to penetrate the ocular tissues and do not cause ocular tissue toxicity. As ocular absorption enhancers, non-invasive routes could be used to achieve intraocular drug delivery and increase the ocular bioavailability of drugs. These penetratin derivatives and the ophthalmic drug delivery system constructed by them are used for eye drop administration, which could replace the intraocular injection with poor patients compliance, which greatly enhances the convenience and safety of the treatment of intraocular and fundus diseases.
    Type: Application
    Filed: August 24, 2021
    Publication date: January 13, 2022
    Inventors: Gang Wei, Kuan Jiang, Weiyue Lu, Chang Liu, Lingyu Tai, Xin Gao
  • Patent number: 11213591
    Abstract: The present disclosure belongs to the field of pharmaceutical preparations and relates to the design of a series of lipophilic derivatives by using wild-type penetrating peptide penetratin. These penetratin derivatives have a strong ability to penetrate the ocular tissues and do not cause ocular tissue toxicity. As ocular absorption enhancers, non-invasive routes could be used to achieve intraocular drug delivery and increase the ocular bioavailability of drugs. These penetratin derivatives and the ophthalmic drug delivery system constructed by them are used for eye drop administration, which could replace the intraocular injection with poor patients compliance, which greatly enhances the convenience and safety of the treatment of intraocular and fundus diseases.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: January 4, 2022
    Assignee: FUDAN UNIVERSITY
    Inventors: Gang Wei, Kuan Jiang, Weiyue Lu, Chang Liu, Lingyu Tai, Xin Gao
  • Patent number: 11029165
    Abstract: A sensor unit includes a sensor interface and a host interface. The sensor interface can be coupled to a number of sensors mounted on various locations of the ADV. The host interface can be coupled to a host system that is configured to perceive a driving environment surrounding the ADV based on sensor data obtained from the sensors and to plan a path to autonomously drive the ADV. The sensor unit further includes a sensor processing module and a sensor control module coupled to the sensor interface, and a time module coupled to the sensor processing module and the sensor control module. The sensor processing module is configured to process sensor data received from the sensors via the sensor interface. The sensor control module is configured to control operations of the sensors. The time module is configured to generate time to synchronize timing of the operations of the sensors.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: June 8, 2021
    Assignee: BAIDU USA LLC
    Inventors: Zhou Xu, Manjiang Zhang, Xiangtao You, Weiyu Lu, Fu-Kang Liao
  • Publication number: 20200237925
    Abstract: The present disclosure belongs to the field of pharmaceutical preparations and relates to the design of a series of lipophilic derivatives by using wild-type penetrating peptide penetratin. These penetratin derivatives have a strong ability to penetrate the ocular tissues and do not cause ocular tissue toxicity. As ocular absorption enhancers, non-invasive routes could be used to achieve intraocular drug delivery and increase the ocular bioavailability of drugs. These penetratin derivatives and the ophthalmic drug delivery system constructed by them are used for eye drop administration, which could replace the intraocular injection with poor patients compliance, which greatly enhances the convenience and safety of the treatment of intraocular and fundus diseases.
    Type: Application
    Filed: July 13, 2018
    Publication date: July 30, 2020
    Inventors: Gang Wei, Kuan Jiang, Weiyue Lu, Chang Liu, Lingyu Tai, Xin Gao
  • Patent number: 10645848
    Abstract: A sensor unit utilized in an autonomous driving vehicle (ADV) includes a unit tray containing a sensor interface, a host interface, and one or more sensor processing modules. The sensor interface can be coupled to a variety of sensors used in the ADV, such as, for example, LIDAR, RADAR, cameras, etc., which may be mounted on different locations of the ADV. The host interface can be coupled a host system that is responsible for autonomously driving the vehicle. The host system is configured to perceive a driving environment surrounding the ADV base on sensor data obtained from the sensors and plan a path to autonomously drive the vehicle through the driving environment. The sensor processing modules are configured to process the sensor data obtained from the sensors.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: May 5, 2020
    Assignee: BAIDU USA LLC
    Inventors: Weiyu Lu, Fu-Kang Liao
  • Publication number: 20200137928
    Abstract: A sensor unit utilized in an autonomous driving vehicle (ADV) includes a unit tray containing a sensor interface, a host interface, and one or more sensor processing modules. The sensor interface can be coupled to a variety of sensors used in the ADV, such as, for example, LIDAR, RADAR, cameras, etc., which may be mounted on different locations of the ADV. The host interface can be coupled a host system that is responsible for autonomously driving the vehicle. The host system is configured to perceive a driving environment surrounding the ADV base on sensor data obtained from the sensors and plan a path to autonomously drive the vehicle through the driving environment. The sensor processing modules are configured to process the sensor data obtained from the sensors.
    Type: Application
    Filed: October 24, 2018
    Publication date: April 30, 2020
    Inventors: WEIYU LU, Fu-Kang LIAO
  • Publication number: 20200116502
    Abstract: A sensor unit includes a sensor interface and a host interface. The sensor interface can be coupled to a number of sensors mounted on various locations of the ADV. The host interface can be coupled to a host system that is configured to perceive a driving environment surrounding the ADV based on sensor data obtained from the sensors and to plan a path to autonomously drive the ADV. The sensor unit further includes a sensor processing module and a sensor control module coupled to the sensor interface, and a time module coupled to the sensor processing module and the sensor control module. The sensor processing module is configured to process sensor data received from the sensors via the sensor interface. The sensor control module is configured to control operations of the sensors. The time module is configured to generate time to synchronize timing of the operations of the sensors.
    Type: Application
    Filed: October 11, 2018
    Publication date: April 16, 2020
    Inventors: Zhou XU, Manjiang ZHANG, Xiangtao YOU, Weiyu LU, Fu-Kang LIAO
  • Publication number: 20200069601
    Abstract: A nano drug delivery system includes a biofilm-coated drug nanocrystal. A drug in a physical form of nanocrystal is directly used as a rigid supporting skeleton, and is filled in a biofilm. The nano drug delivery system has the advantages of high drug loading capacity, good biocompatibility, long systemic circulation time and drug sustained release.
    Type: Application
    Filed: March 30, 2018
    Publication date: March 5, 2020
    Applicant: Shanghai Whittlong Pharmaceutical Institute
    Inventors: Weiyue LU, Zhilan CHAI, Xuefeng HU, Cao XIE, Huimin HOU, Hao WANG
  • Patent number: 10474206
    Abstract: According to some embodiments, before an M.2 compatible module or device is mounted onto a data processing system that operates an autonomous driving vehicle (ADV), the M.2 module is placed onto a tray device to increase the stiffness of the M.2 module. The tray device containing the M.2 module is then mounted on a board or motherboard of the data processing system. Since the M.2 module is placed on the tray device, the overall stiffness has been significantly increased, which can sustain the physical impact on the M.2 module due to the physical movement and oscillation during the autonomous driving of the ADV. In addition, the tray device also provides suspension effect on the M.2 module during the movement of the ADV. As a result, the M.2 module would not easily damaged during the autonomous driving.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: November 12, 2019
    Assignee: BAIDU USA LLC
    Inventors: Weiyu Lu, Ji Li, Fu-kang Liao
  • Publication number: 20190314446
    Abstract: Provided in the present invention are highly stable D-configuration polypeptides DVAP and SVAP having a high binding activity to the GRP78 protein, and also provided are an L-configuration polypeptide LVAP and a DVAP-or SVAP-modified model drug and a macromolecule carrier material, and the use thereof in the construction of a tumour image and a drug-delivery system for targeted treatment.
    Type: Application
    Filed: December 6, 2017
    Publication date: October 17, 2019
    Inventors: Weiyue Lu, Danni Ran, Jiani Mao, Cao Xie
  • Patent number: 9635785
    Abstract: A data center system includes a container to contain electronic racks of IT components operating therein, a cooling unit disposed underneath the electronic racks to receive cool liquid from a chiller unit, to exchange heat generated from the IT components, and to transmit the hot liquid carrying the exchanged heat back to the chiller unit. Each electronic rack includes a housing to house IT components arranged in a stack, a first rack aisle formed on a first side of the IT components to direct cool air received from the cooling unit upwardly, and a second rack aisle formed on a second side of the IT components to direct hot air to the cooling unit downwardly, where the host air is transformed from the cool air from the first rack aisle by flowing through an air space between the IT components.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: April 25, 2017
    Assignee: BAIDU USA LLC
    Inventors: Ali Heydari, Eric Mahendra Kumar, Charles J. Ingalz, Weiyu Lu, Tianyi Gao, Manasa Sahini, Yan Cui
  • Publication number: 20170105317
    Abstract: A data center system includes a container to contain electronic racks of IT components operating therein, a cooling unit disposed underneath the electronic racks to receive cool liquid from a chiller unit, to exchange heat generated from the IT components, and to transmit the hot liquid carrying the exchanged heat back to the chiller unit. Each electronic rack includes a housing to house IT components arranged in a stack, a first rack aisle formed on a first side of the IT components to direct cool air received from the cooling unit upwardly, and a second rack aisle formed on a second side of the IT components to direct hot air to the cooling unit downwardly, where the host air is transformed from the cool air from the first rack aisle by flowing through an air space between the IT components.
    Type: Application
    Filed: November 9, 2015
    Publication date: April 13, 2017
    Inventors: Ali Heydari, Eric Mahendra Kumar, Charles J. Ingalz, Weiyu Lu, Tianyi Gao, Manasa Sahini, Yan Cui
  • Publication number: 20160074321
    Abstract: The present invention is directed to an ophthalmic composition, method for preparing the same, and use of the same. The ophthalmic composition includes a mixture of lipid nano-dispersion and gel substrate, wherein the lipid nano-dispersion includes a first lipid, a second lipid, and emulsifier; in which the first lipid exists in form of solid lipid as staring material, and the second lipid exists in form of liquid lipid as staring material. The ophthalmic composition can better reduce the symptoms of dry eye, and is safe, convenient and economical to use, and can be used during daytime without blocking of vision.
    Type: Application
    Filed: March 27, 2013
    Publication date: March 17, 2016
    Inventors: Gang WEI, Benjamin Tak Kwong LEE, Wenjian ZHANG, Weiyue LU, Johnson Yiu-Nam LAU, Shun Chiu Dennis LAM
  • Patent number: 7005426
    Abstract: The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof, pharmaceutical compositions having said complex as active component and uses of said composition in therapy of tumors. The folic acid-polysaccharide complexs of the present invention have general formula of: (X)n—Y, wherein X is identical or different, and is selected from folic acid, derivatives of folic acid and other substances that can enter into cell via the pathway of folic acid receptor; Y is polysaccharide; n?1.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: February 28, 2006
    Assignee: Shanghai Pharmco Research, Inc.
    Inventors: Weiyue Lu, Min Liu, Jun Pan
  • Publication number: 20030125302
    Abstract: The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof, pharmaceutical compositions having said complex as active component and uses of said composition in therapy of tumors. The folic acid-polysaccharide complexs of the present invention have general formula of: (X)n—Y, wherein X is identical or different, and is selected from folic acid, derivatives of folic acid and other substances that can enter into cell via the pathway of folic acid receptor; Y is polysaccharide; n≧1.
    Type: Application
    Filed: October 17, 2002
    Publication date: July 3, 2003
    Applicant: Fudan University
    Inventors: Weiyue Lu, Min Liu, Jun Pan