Patents by Inventor Weiyu Lu
Weiyu Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11826431Abstract: The present disclosure belongs to the field of pharmaceutical preparations and relates to the design of a series of lipophilic derivatives by using wild-type penetrating peptide penetratin. These penetratin derivatives have a strong ability to penetrate the ocular tissues and do not cause ocular tissue toxicity. As ocular absorption enhancers, non-invasive routes could be used to achieve intraocular drug delivery and increase the ocular bioavailability of drugs. These penetratin derivatives and the ophthalmic drug delivery system constructed by them are used for eye drop administration, which could replace the intraocular injection with poor patients compliance, which greatly enhances the convenience and safety of the treatment of intraocular and fundus diseases.Type: GrantFiled: August 24, 2021Date of Patent: November 28, 2023Assignee: FUDAN UNIVERSITYInventors: Gang Wei, Kuan Jiang, Weiyue Lu, Chang Liu, Lingyu Tai, Xin Gao
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VAP polypeptide and use thereof in preparation of drug for targeted diagnosis and treatment of tumor
Patent number: 11622990Abstract: Provided in the present invention are highly stable D-configuration polypeptides DVAP and SVAP having a high binding activity to the GRP78 protein, and also provided are an L-configuration polypeptide LVAP and a DVAP-or SVAP-modified model drug and a macromolecule carrier material, and the use thereof in the construction of a tumour image and a drug-delivery system for targeted treatment.Type: GrantFiled: December 6, 2017Date of Patent: April 11, 2023Assignee: FUDAN UNIVERSITYInventors: Weiyue Lu, Danni Ran, Jiani Mao, Cao Xie -
Patent number: 11260032Abstract: A nano drug delivery system includes a biofilm-coated drug nanocrystal. A drug in a physical form of nanocrystal is directly used as a rigid supporting skeleton, and is filled in a biofilm. The nano drug delivery system has the advantages of high drug loading capacity, good biocompatibility, long systemic circulation time and drug sustained release.Type: GrantFiled: March 30, 2018Date of Patent: March 1, 2022Assignee: Shanghai Whittlong Pharmaceutical InstituteInventors: Weiyue Lu, Zhilan Chai, Xuefeng Hu, Cao Xie, Huimin Hou, Hao Wang
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Publication number: 20220008546Abstract: The present disclosure belongs to the field of pharmaceutical preparations and relates to the design of a series of lipophilic derivatives by using wild-type penetrating peptide penetratin. These penetratin derivatives have a strong ability to penetrate the ocular tissues and do not cause ocular tissue toxicity. As ocular absorption enhancers, non-invasive routes could be used to achieve intraocular drug delivery and increase the ocular bioavailability of drugs. These penetratin derivatives and the ophthalmic drug delivery system constructed by them are used for eye drop administration, which could replace the intraocular injection with poor patients compliance, which greatly enhances the convenience and safety of the treatment of intraocular and fundus diseases.Type: ApplicationFiled: August 24, 2021Publication date: January 13, 2022Inventors: Gang Wei, Kuan Jiang, Weiyue Lu, Chang Liu, Lingyu Tai, Xin Gao
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Patent number: 11213591Abstract: The present disclosure belongs to the field of pharmaceutical preparations and relates to the design of a series of lipophilic derivatives by using wild-type penetrating peptide penetratin. These penetratin derivatives have a strong ability to penetrate the ocular tissues and do not cause ocular tissue toxicity. As ocular absorption enhancers, non-invasive routes could be used to achieve intraocular drug delivery and increase the ocular bioavailability of drugs. These penetratin derivatives and the ophthalmic drug delivery system constructed by them are used for eye drop administration, which could replace the intraocular injection with poor patients compliance, which greatly enhances the convenience and safety of the treatment of intraocular and fundus diseases.Type: GrantFiled: July 13, 2018Date of Patent: January 4, 2022Assignee: FUDAN UNIVERSITYInventors: Gang Wei, Kuan Jiang, Weiyue Lu, Chang Liu, Lingyu Tai, Xin Gao
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Patent number: 11029165Abstract: A sensor unit includes a sensor interface and a host interface. The sensor interface can be coupled to a number of sensors mounted on various locations of the ADV. The host interface can be coupled to a host system that is configured to perceive a driving environment surrounding the ADV based on sensor data obtained from the sensors and to plan a path to autonomously drive the ADV. The sensor unit further includes a sensor processing module and a sensor control module coupled to the sensor interface, and a time module coupled to the sensor processing module and the sensor control module. The sensor processing module is configured to process sensor data received from the sensors via the sensor interface. The sensor control module is configured to control operations of the sensors. The time module is configured to generate time to synchronize timing of the operations of the sensors.Type: GrantFiled: October 11, 2018Date of Patent: June 8, 2021Assignee: BAIDU USA LLCInventors: Zhou Xu, Manjiang Zhang, Xiangtao You, Weiyu Lu, Fu-Kang Liao
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Publication number: 20200237925Abstract: The present disclosure belongs to the field of pharmaceutical preparations and relates to the design of a series of lipophilic derivatives by using wild-type penetrating peptide penetratin. These penetratin derivatives have a strong ability to penetrate the ocular tissues and do not cause ocular tissue toxicity. As ocular absorption enhancers, non-invasive routes could be used to achieve intraocular drug delivery and increase the ocular bioavailability of drugs. These penetratin derivatives and the ophthalmic drug delivery system constructed by them are used for eye drop administration, which could replace the intraocular injection with poor patients compliance, which greatly enhances the convenience and safety of the treatment of intraocular and fundus diseases.Type: ApplicationFiled: July 13, 2018Publication date: July 30, 2020Inventors: Gang Wei, Kuan Jiang, Weiyue Lu, Chang Liu, Lingyu Tai, Xin Gao
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Container structure with builtin heatsink for housing a sensor unit of an autonomous driving vehicle
Patent number: 10645848Abstract: A sensor unit utilized in an autonomous driving vehicle (ADV) includes a unit tray containing a sensor interface, a host interface, and one or more sensor processing modules. The sensor interface can be coupled to a variety of sensors used in the ADV, such as, for example, LIDAR, RADAR, cameras, etc., which may be mounted on different locations of the ADV. The host interface can be coupled a host system that is responsible for autonomously driving the vehicle. The host system is configured to perceive a driving environment surrounding the ADV base on sensor data obtained from the sensors and plan a path to autonomously drive the vehicle through the driving environment. The sensor processing modules are configured to process the sensor data obtained from the sensors.Type: GrantFiled: October 24, 2018Date of Patent: May 5, 2020Assignee: BAIDU USA LLCInventors: Weiyu Lu, Fu-Kang Liao -
CONTAINER STRUCTURE WITH BUILTIN HEATSINK FOR HOUSING A SENSOR UNIT OF AN AUTONOMOUS DRIVING VEHICLE
Publication number: 20200137928Abstract: A sensor unit utilized in an autonomous driving vehicle (ADV) includes a unit tray containing a sensor interface, a host interface, and one or more sensor processing modules. The sensor interface can be coupled to a variety of sensors used in the ADV, such as, for example, LIDAR, RADAR, cameras, etc., which may be mounted on different locations of the ADV. The host interface can be coupled a host system that is responsible for autonomously driving the vehicle. The host system is configured to perceive a driving environment surrounding the ADV base on sensor data obtained from the sensors and plan a path to autonomously drive the vehicle through the driving environment. The sensor processing modules are configured to process the sensor data obtained from the sensors.Type: ApplicationFiled: October 24, 2018Publication date: April 30, 2020Inventors: WEIYU LU, Fu-Kang LIAO -
Publication number: 20200116502Abstract: A sensor unit includes a sensor interface and a host interface. The sensor interface can be coupled to a number of sensors mounted on various locations of the ADV. The host interface can be coupled to a host system that is configured to perceive a driving environment surrounding the ADV based on sensor data obtained from the sensors and to plan a path to autonomously drive the ADV. The sensor unit further includes a sensor processing module and a sensor control module coupled to the sensor interface, and a time module coupled to the sensor processing module and the sensor control module. The sensor processing module is configured to process sensor data received from the sensors via the sensor interface. The sensor control module is configured to control operations of the sensors. The time module is configured to generate time to synchronize timing of the operations of the sensors.Type: ApplicationFiled: October 11, 2018Publication date: April 16, 2020Inventors: Zhou XU, Manjiang ZHANG, Xiangtao YOU, Weiyu LU, Fu-Kang LIAO
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Publication number: 20200069601Abstract: A nano drug delivery system includes a biofilm-coated drug nanocrystal. A drug in a physical form of nanocrystal is directly used as a rigid supporting skeleton, and is filled in a biofilm. The nano drug delivery system has the advantages of high drug loading capacity, good biocompatibility, long systemic circulation time and drug sustained release.Type: ApplicationFiled: March 30, 2018Publication date: March 5, 2020Applicant: Shanghai Whittlong Pharmaceutical InstituteInventors: Weiyue LU, Zhilan CHAI, Xuefeng HU, Cao XIE, Huimin HOU, Hao WANG
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Patent number: 10474206Abstract: According to some embodiments, before an M.2 compatible module or device is mounted onto a data processing system that operates an autonomous driving vehicle (ADV), the M.2 module is placed onto a tray device to increase the stiffness of the M.2 module. The tray device containing the M.2 module is then mounted on a board or motherboard of the data processing system. Since the M.2 module is placed on the tray device, the overall stiffness has been significantly increased, which can sustain the physical impact on the M.2 module due to the physical movement and oscillation during the autonomous driving of the ADV. In addition, the tray device also provides suspension effect on the M.2 module during the movement of the ADV. As a result, the M.2 module would not easily damaged during the autonomous driving.Type: GrantFiled: August 13, 2018Date of Patent: November 12, 2019Assignee: BAIDU USA LLCInventors: Weiyu Lu, Ji Li, Fu-kang Liao
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VAP POLYPEPTIDE AND USE THEREOF IN PREPARATION OF DRUG FOR TARGETED DIAGNOSIS AND TREATMENT OF TUMOR
Publication number: 20190314446Abstract: Provided in the present invention are highly stable D-configuration polypeptides DVAP and SVAP having a high binding activity to the GRP78 protein, and also provided are an L-configuration polypeptide LVAP and a DVAP-or SVAP-modified model drug and a macromolecule carrier material, and the use thereof in the construction of a tumour image and a drug-delivery system for targeted treatment.Type: ApplicationFiled: December 6, 2017Publication date: October 17, 2019Inventors: Weiyue Lu, Danni Ran, Jiani Mao, Cao Xie -
Patent number: 9635785Abstract: A data center system includes a container to contain electronic racks of IT components operating therein, a cooling unit disposed underneath the electronic racks to receive cool liquid from a chiller unit, to exchange heat generated from the IT components, and to transmit the hot liquid carrying the exchanged heat back to the chiller unit. Each electronic rack includes a housing to house IT components arranged in a stack, a first rack aisle formed on a first side of the IT components to direct cool air received from the cooling unit upwardly, and a second rack aisle formed on a second side of the IT components to direct hot air to the cooling unit downwardly, where the host air is transformed from the cool air from the first rack aisle by flowing through an air space between the IT components.Type: GrantFiled: November 9, 2015Date of Patent: April 25, 2017Assignee: BAIDU USA LLCInventors: Ali Heydari, Eric Mahendra Kumar, Charles J. Ingalz, Weiyu Lu, Tianyi Gao, Manasa Sahini, Yan Cui
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Publication number: 20170105317Abstract: A data center system includes a container to contain electronic racks of IT components operating therein, a cooling unit disposed underneath the electronic racks to receive cool liquid from a chiller unit, to exchange heat generated from the IT components, and to transmit the hot liquid carrying the exchanged heat back to the chiller unit. Each electronic rack includes a housing to house IT components arranged in a stack, a first rack aisle formed on a first side of the IT components to direct cool air received from the cooling unit upwardly, and a second rack aisle formed on a second side of the IT components to direct hot air to the cooling unit downwardly, where the host air is transformed from the cool air from the first rack aisle by flowing through an air space between the IT components.Type: ApplicationFiled: November 9, 2015Publication date: April 13, 2017Inventors: Ali Heydari, Eric Mahendra Kumar, Charles J. Ingalz, Weiyu Lu, Tianyi Gao, Manasa Sahini, Yan Cui
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Publication number: 20160074321Abstract: The present invention is directed to an ophthalmic composition, method for preparing the same, and use of the same. The ophthalmic composition includes a mixture of lipid nano-dispersion and gel substrate, wherein the lipid nano-dispersion includes a first lipid, a second lipid, and emulsifier; in which the first lipid exists in form of solid lipid as staring material, and the second lipid exists in form of liquid lipid as staring material. The ophthalmic composition can better reduce the symptoms of dry eye, and is safe, convenient and economical to use, and can be used during daytime without blocking of vision.Type: ApplicationFiled: March 27, 2013Publication date: March 17, 2016Inventors: Gang WEI, Benjamin Tak Kwong LEE, Wenjian ZHANG, Weiyue LU, Johnson Yiu-Nam LAU, Shun Chiu Dennis LAM
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Patent number: 7005426Abstract: The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof, pharmaceutical compositions having said complex as active component and uses of said composition in therapy of tumors. The folic acid-polysaccharide complexs of the present invention have general formula of: (X)n—Y, wherein X is identical or different, and is selected from folic acid, derivatives of folic acid and other substances that can enter into cell via the pathway of folic acid receptor; Y is polysaccharide; n?1.Type: GrantFiled: October 17, 2002Date of Patent: February 28, 2006Assignee: Shanghai Pharmco Research, Inc.Inventors: Weiyue Lu, Min Liu, Jun Pan
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Publication number: 20030125302Abstract: The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof, pharmaceutical compositions having said complex as active component and uses of said composition in therapy of tumors. The folic acid-polysaccharide complexs of the present invention have general formula of: (X)n—Y, wherein X is identical or different, and is selected from folic acid, derivatives of folic acid and other substances that can enter into cell via the pathway of folic acid receptor; Y is polysaccharide; n≧1.Type: ApplicationFiled: October 17, 2002Publication date: July 3, 2003Applicant: Fudan UniversityInventors: Weiyue Lu, Min Liu, Jun Pan