Patents by Inventor Weizao Chen

Weizao Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-affinity fully functional soluble single-domain human CD4, antibodies, and related fusion proteins
    Patent number: 8911728
    Abstract: The invention provides engineered antibody domains (eAds), a polypeptide comprising a single domain CD4, as well as a fusion protein comprising the same. Nucleic acids encoding eAd and/or polypeptide or the fusion protein thereof, as well as compositions or cells comprising the eAd, polypeptide, fusion protein, or nucleic acid also are provided.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: December 16, 2014
    Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dimiter S. Dimitrov, Weizao Chen
  • MONOSPECIFIC AND BISPECIFIC HUMAN MONOCLONAL ANTIBODIES TARGETING INSULIN-LIKE GROWTH FACTOR II (IGF-II)
    Publication number: 20140271646
    Abstract: Monoclonal antibodies (mAbs), antigen binding fragments and engineered antibody domains (eAds) that specifically bind IGF-II are disclosed herein. In some embodiments, these mAbs and eAds are included in a bispecific mAb. In some embodiments, the bispecific antibody specifically binds two different epitopes of IGF-II. Methods of using these mAbs, antigen binding fragments, and eAds, bispecific antibodies, and nucleic acids encoding these mAbs, antigen binding fragments, and eAds, bispecific antibodies are also disclosed.
    Type: Application
    Filed: October 16, 2012
    Publication date: September 18, 2014
    Inventors: Dimiter S. Dimitrov, Weizao Chen, Yang Feng
  • HIGH-AFFINITY FULLY FUNCTIONAL SOLUBLE SINGLE-DOMAIN HUMAN CD4, ANTIBODIES, AND RELATED FUSION PROTEINS
    Publication number: 20130108636
    Abstract: The invention provides engineered antibody domains (eAds), a polypeptide comprising a single domain CD4, as well as a fusion protein comprising the same. Nucleic acids encoding eAd and/or polypeptide or the fusion protein thereof, as well as compositions or cells comprising the eAd, polypeptide, fusion protein, or nucleic acid also are provided.
    Type: Application
    Filed: May 20, 2011
    Publication date: May 2, 2013
    Inventors: Dimiter S. Dimitrov, Weizao Chen
  • HUMAN DOMAIN ANTIBODIES AGAINST COMPONENTS OF THE HUMAN INSULIN-LIKE GROWTH FACTOR (IGF) SYSTEM
    Publication number: 20120195897
    Abstract: The invention provides antibodies or antibody fragments that bind to insulin-like growth factor (IGF) 1 receptor (IGF-1R) or IGF-2, as well as method of using the antibodies for inhibiting the IGF-mediated signaling pathway, inhibiting IGF-1R signaling, and treating cancer. The invention also provides a method of detecting the presence of IGF-1R or IGF-2 in a sample using the inventive antibodies and antibody fragments.
    Type: Application
    Filed: October 7, 2010
    Publication date: August 2, 2012
    Inventors: Dimiter S. Dimitrov, Weizao Chen
  • ANTI-HIV DOMAIN ANTIBODIES AND METHOD OF MAKING AND USING SAME
    Publication number: 20110104163
    Abstract: The invention provides single domain antibodies and derivatives thereof that bind antigens of interest, which are stable, soluble, and do not tend to aggregate. The invention also provides methods for constructing a dAb library and methods for screening dAb libraries to identify the dAb of the invention. The invention also provide methods of treating or preventing conditions by antigen neutralization by administering the dAbs of the invention.
    Type: Application
    Filed: January 7, 2009
    Publication date: May 5, 2011
    Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY TH
    Inventors: Dimiter S. Dimitrov, Weizao Chen