Patents by Inventor Weizheng Xu

Weizheng Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP
    Publication number: 20090298837
    Abstract: The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Application
    Filed: August 13, 2009
    Publication date: December 3, 2009
    Applicant: Eisai Corporation of North America
    Inventors: Vincent J. Kalish, Jie Zhang, Weizheng Xu, Jia-He Li, Amy Dongxia Xing, Qun Liu
  • Compounds, methods and pharmaceutical compositions for inhibiting PARP
    Patent number: 7601719
    Abstract: The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: October 13, 2009
    Assignee: Eisai Corporation of North America
    Inventors: Vincent Kalish, Jie Zhang, Weizheng Xu, Jia-He Li, Amy D. Xing, Qun Liu
  • PARP INHIBITOR COMPOUNDS, COMPOSITIONS AND METHODS OF USE
    Publication number: 20090098084
    Abstract: The present invention relates to tetraaza phenalen-3-one compounds which inhibit poly (ADP-ribose) polymerase (PARP) and are useful in the chemosensitization of cancer therapeutics. The induction of peripheral neuropathy is a common side-effect of many of the conventional and newer chemotherapies. The present invention further provides means to reliably prevent or cure chemotherapy-induced neuropathy. The invention also relates to the use of the disclosed PARP inhibitor compounds in enhancing the efficacy of chemotherapeutic agents such as temozolomide. The invention also relates to the use of the disclosed PARP inhibitor compounds to radiosensitize tumor cells to ionizing radiation. The invention also relates to the use of the disclosed PARP inhibitor compounds for treatment of cancers with DNA repair defects.
    Type: Application
    Filed: October 2, 2008
    Publication date: April 16, 2009
    Applicant: MGI GP, Inc.
    Inventors: Weizheng Xu, Greg Delahanty, Ling Wei, Jie Zhang
  • COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP
    Publication number: 20090088407
    Abstract: The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Application
    Filed: October 20, 2008
    Publication date: April 2, 2009
    Applicant: MGI GP, Inc.
    Inventors: Vincent J. Kalish, Jie Zhang, Weizheng Xu, Jia-He Li, Amy Dongxia Xing, Qun Liu
  • Diazabenzo[De]anthracen-3-one Compounds and Methods for Inhibiting Parp
    Publication number: 20090028815
    Abstract: The present invention relates to diazabenzo[de]anthracen-3-one compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Application
    Filed: January 19, 2006
    Publication date: January 29, 2009
    Applicant: MGI GP, INC.
    Inventors: Weizheng Xu, Greg Delahanty, Jie Zhang
  • Compounds, methods and pharmaceutical compositions for inhibiting PARP
    Patent number: 7456178
    Abstract: The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: November 25, 2008
    Assignee: MGI GP, Inc.
    Inventors: Vincent Kalish, Jie Zhang, Weizheng Xu, Jia-He Li, Amy Dongxia Xing, Qun Liu
  • COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP
    Publication number: 20080058325
    Abstract: The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”) compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Application
    Filed: August 6, 2007
    Publication date: March 6, 2008
    Applicant: MGI GP, INC.
    Inventors: Vincent Kalish, Jie Zhang, Weizheng Xu, Jia-He Li, Amy Xing, Qun Liu
  • Compounds, methods and pharmaceutical compositions for inhibiting PARP
    Patent number: 7268138
    Abstract: The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: September 11, 2007
    Assignee: MGI GP, Inc.
    Inventors: Vincent J. Kalish, Jie Zhang, Weizheng Xu, Jia-He Li, Amy Dongxia Xing, Qun Liu
  • Compounds, derivatives, compositions, preparation and uses
    Patent number: 7247641
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: July 24, 2007
    Assignee: MGI GP, Inc.
    Inventors: Weizheng Xu, Dana V. Ferraris, Jia-He Li, Vincent J. Kalish
  • Hydroxamic acids and acyl hydroxamines as NAALADase inhibitors
    Publication number: 20060009525
    Abstract: This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-? activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
    Type: Application
    Filed: March 1, 2005
    Publication date: January 12, 2006
    Inventors: Takashi Tsukamoto, Pavel Majer, Bunda Hin, Weizheng Xu, Qun Liu, Doris Stoermer
  • Hydroxamic acids and acyl hydroxamines as naaladase inhibitors
    Patent number: 6884907
    Abstract: This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-? activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: April 26, 2005
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Takashi Tsukamoto, Pavel Majer, Bunda Hin, Weizheng Xu, Qun Liu, Doris Stoermer
  • Inhibitors of dipeptidyl peptidase iv
    Publication number: 20050070719
    Abstract: Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.
    Type: Application
    Filed: December 26, 2002
    Publication date: March 31, 2005
    Inventors: Sergei Belyakov, Gregory Hamilton, David Hurst, Vincent Kalish, Weixing Li, Eric Wang, Douglas Wilkinson, Yong-Qian Wu, Weizheng Xu
  • Compounds, methods and pharmaceutical compositions for inhibiting PARP
    Publication number: 20050020595
    Abstract: The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Application
    Filed: May 26, 2004
    Publication date: January 27, 2005
    Inventors: Vincent Kalish, Jie Zhang, Weizheng Xu, Jia-He Li, Amy Xing, Qun Liu
  • Compounds, derivatives, compositions, preparation and uses
    Publication number: 20040254372
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
    Type: Application
    Filed: February 9, 2004
    Publication date: December 16, 2004
    Inventors: Weizheng Xu, Dana V. Ferraris, Jia-He Li, Vincent J. Kalish
  • Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use
    Publication number: 20040063785
    Abstract: Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Application
    Filed: August 28, 2003
    Publication date: April 1, 2004
    Applicant: Guilford Pharmaceuticals, Inc.
    Inventors: Jia-He Li, Dana Victor Ferraris, Paul W. Kletzly, Weixing Li, Eric Yanjun Wang, Amy D. Xing, Weizheng Xu, Jie Zhang
  • Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use
    Patent number: 6635786
    Abstract: Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Grant
    Filed: April 10, 2001
    Date of Patent: October 21, 2003
    Assignee: Guilford Pharmaceuticals, Inc.
    Inventors: Jia-He Li, Dana Victor Ferraris, Paul W. Kletzly, Weixing Li, Eric Yanjun Wang, Amy D. Xing, Weizheng Xu, Jie Zhang
  • Hydroxamic acids and acyl hydroxamines as naaladase inhibitors
    Publication number: 20030087897
    Abstract: This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
    Type: Application
    Filed: May 10, 2002
    Publication date: May 8, 2003
    Inventors: Takashi Tsukamoto, Pavel Majer, Bunda Hin, Weizheng Xu, Qun Liu, Doris Stoermer
  • Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use
    Publication number: 20020132852
    Abstract: Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Application
    Filed: April 10, 2001
    Publication date: September 19, 2002
    Inventors: Jia-He Li, Dana Victor Ferraris, Paul W. Kletzly, Weixing Li, Eric Yanjun Wang, Amy D. Xing, Weizheng Xu, Jie Zhang