Patents by Inventor Wen-Bin Ho

Wen-Bin Ho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20130178417
    Abstract: The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
    Type: Application
    Filed: August 30, 2012
    Publication date: July 11, 2013
    Inventors: Michael P. AREND, Lee A. FLIPPIN, Volkmar GUENZLER-PUKALL, Wen-Bin HO, Eric D. TURTLE, Xiaohui DU
  • Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
    Patent number: 8324405
    Abstract: The present invention relates to novel compounds of formula (I), methods, and compositions capable of decreasing HIF hydroxylase activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: December 4, 2012
    Assignee: FibroGen, Inc.
    Inventors: Wen-bin Ho, Lee Wright, Shaojiang Deng, Eric Turtle, Lee A. Flippin
  • Nitrogen-containing heteroaryl compounds and methods of use thereof
    Patent number: 8278325
    Abstract: The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: October 2, 2012
    Assignee: FibroGen, Inc.
    Inventors: Michael P. Arend, Lee A. Flippin, Volkmar Guenzler-Pukall, Wen-Bin Ho, Eric Turtle, Xiaohui Du
  • CYANOISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20120178755
    Abstract: The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions.
    Type: Application
    Filed: March 26, 2012
    Publication date: July 12, 2012
    Inventors: Michael Arend, Lee A. Flippin, Min Wu, Eric D. Turtle, Wen-Bin Ho, Shaojiang Deng
  • Compounds and methods for their use
    Patent number: 8217043
    Abstract: The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase enzyme.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: July 10, 2012
    Assignee: Fibrogen, Inc.
    Inventors: Shaojiang Deng, Wen-Bin Ho, Lee A. Flippin
  • NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20120029011
    Abstract: The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
    Type: Application
    Filed: July 19, 2011
    Publication date: February 2, 2012
    Inventors: Michael P. Arend, Lee A. Flippin, Volkmar Guenzler-Pukall, Wen-Bin Ho, Eric D. Turtle, Xiaohui Du
  • THIOCHROMENE DERIVATIVES AS HIF HYDROXYLASE INHIBITORS
    Publication number: 20110305776
    Abstract: The present invention relates to novel compounds, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).
    Type: Application
    Filed: November 11, 2009
    Publication date: December 15, 2011
    Applicant: FibroGen, Inc.
    Inventors: Wen-Bin Ho, Lee A. Flippin, Craig Mossman, Eric D. Turtle, Lee R. Wright
  • Cyanoisoquinoline Compounds and Methods of Use Thereof
    Publication number: 20110212959
    Abstract: The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions.
    Type: Application
    Filed: March 7, 2011
    Publication date: September 1, 2011
    Inventors: Michael P. Arend, Lee A. Flippin, Min Wu, Eric D. Turtle, Wen-Bin Ho, Shaojiang Deng
  • Cyanoisoquinoline compounds and methods of use thereof
    Patent number: 7928120
    Abstract: The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: April 19, 2011
    Assignee: FibroGen, Inc.
    Inventors: Michael Arend, Lee A. Flippin, Min Wu, Eric D. Turtle, Wen-Bin Ho, Shaojiang Deng
  • Nitrogen-containing heteroaryl compounds and methods of use thereof
    Patent number: 7863292
    Abstract: The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
    Type: Grant
    Filed: January 19, 2007
    Date of Patent: January 4, 2011
    Assignee: FibroGen, Inc.
    Inventors: Michael P. Arend, Lee A. Flippin, Volkmar Guenzler-Pukall, Wen-Bin Ho, Eric Turtle, Xiaohui Du
  • CHROMENE DERIVATIVES AND USE THEREOF AS HIF HYDROXYLASE ACTIVITY INHIBITORS
    Publication number: 20100331400
    Abstract: The present invention relates to novel compounds of formula (I), methods, and compositions capable of decreasing HIF hydroxylase activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).
    Type: Application
    Filed: February 5, 2009
    Publication date: December 30, 2010
    Inventors: Wen-bin Ho, Lee Wright, Shaojiang Deng, Eric Turtle, Lee A. Flippin
  • Pyrrolo- and Thiazolo-pyridine compounds, and methods of use thereof
    Patent number: 7696223
    Abstract: The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF).
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: April 13, 2010
    Assignee: FibroGen, Inc.
    Inventors: Shaojiang Deng, Min Wu, Eric D. Turtle, Wen-Bin Ho, Michael P. Arend, Heng Cheng, Lee A. Flippin
  • COMPOUNDS AND METHODS FOR THEIR USE
    Publication number: 20100047367
    Abstract: The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase enzyme.
    Type: Application
    Filed: August 20, 2009
    Publication date: February 25, 2010
    Inventors: Shaojiang Deng, Wen-Bin Ho, Lee A. Flippin
  • Nitrogen-containing heteroaryl compounds and methods of use thereof
    Patent number: 7323475
    Abstract: The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: January 29, 2008
    Assignee: Fibrogen, Inc.
    Inventors: Michael P. Arend, Lee A. Flippin, Volkmar Guenzler-Pukall, Wen-Bin Ho, Eric Turtle, Xiaohui Du
  • PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF
    Publication number: 20080004309
    Abstract: The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF).
    Type: Application
    Filed: April 4, 2007
    Publication date: January 3, 2008
    Inventors: Shaojiang DENG, Min Wu, Eric Turtle, Wen-Bin Ho, Michael Arend, Heng Cheng, Lee Flippin
  • CYANOISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20070298104
    Abstract: The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions.
    Type: Application
    Filed: January 26, 2007
    Publication date: December 27, 2007
    Inventors: Michael Arend, Lee Flippin, Min Wu, Eric Turtle, Wen-Bin Ho, Shaojiang Deng
  • Novel Nitrogen-Containing Heteroaryl Compounds And Methods of Use Thereof
    Publication number: 20070185159
    Abstract: The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
    Type: Application
    Filed: January 19, 2007
    Publication date: August 9, 2007
    Inventors: Michael AREND, Lee Flippin, Volkmar Guenzler-Pukall, Wen-Bin Ho, Eric Turtle, Xiaohui Du
  • Novel nitrogen-containing heteroaryl compounds and methods of use thereof
    Publication number: 20070155784
    Abstract: The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
    Type: Application
    Filed: October 13, 2006
    Publication date: July 5, 2007
    Inventors: Michael Arend, Lee Flippin, Volkmar Guenzler-Pukall, Wen-Bin Ho, Eric Turtle, Xiaohui Du
  • Novel nitrogen-containing heteroaryl compounds and methods of use thereof
    Publication number: 20060217416
    Abstract: The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
    Type: Application
    Filed: May 26, 2006
    Publication date: September 28, 2006
    Inventors: Michael Arend, Lee Flippin, Volkmar Guenzler-Pukall, Wen-Bin Ho, Eric Turtle, Xiaohui Du
  • Novel nitrogen-containing heteroaryl compounds and methods of use thereof
    Publication number: 20040254215
    Abstract: The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
    Type: Application
    Filed: June 4, 2004
    Publication date: December 16, 2004
    Applicant: FibroGen, Inc.
    Inventors: Michael P. Arend, Lee A. Flippin, Volkmar Guenzler-Pukall, Wen-Bin Ho, Eric D. Turtle, Xiaohui Du