Abstract: An electrical connector includes an electrical connecting base, a press cover, a fastening member and at least one thrust member. The press cover covers on the electrical connecting base, and substantially horizontally placed. A fastening portion and a pivoting portion are respectively formed on two opposite ends of the press cover. The press cover is opened or closed relative to the electrical connecting base around the pivoting portion. The fastening member correspondingly presses against the fastening portion of the press cover when the press cover is horizontally placed. The at least one thrust member urges against the press cover upwards. When the fastening member is released from pressing against the fastening portion, the press cover is urged to pop up, so that an operating space is formed below the press cover, which is sufficient for an operator to open the press cover manually.

Abstract: The present invention provides therapeutically active compounds and compositions as NMDA and MC receptor antagonists, which are useful in preventing and treating central nervous system disorders by inhibiting over-activation of NMDA and/or MC receptors. In one aspect, the present invention provides methods of treating and/or preventing neurodegenerative diseases and neuropathological disorders, methods of providing neuroprotection under stress conditions such as a stroke, methods of enhancing the brain's cognitive functions and methods of treating depression, anxiety and cachexia induced by a chronic disease in mammals and humans.

Abstract: A new method that enables parallel amplification of nucleic sequences from a complex source is disclosed. The amplification is compartmentized into microdroplets by porous-walled hollow glass microspheres and subjected to PCR thermal cycling or isothermal amplification. The rigid wall of the glass microspheres allows very simple and conventional manipulation of the amplification products for downstream application such as sequencing or detection of copy number of specific sequences in a complex sample.

Abstract: A dual phase-locked loop (PLL) circuit includes a phase/frequency detector, a charge pump, a frequency tuning circuit and an N divider. The frequency tuning circuit includes a coarse-tuning circuit, for coarse-tuning an output frequency of the dual PLL circuit to approximate a target frequency; a fine-tuning circuit, for fine-tuning the output frequency of the dual PLL circuit to the target frequency; and a current control oscillator (CCO), for generating an output signal of the dual PLL circuit. The output frequency of the output signal is equal to the target frequency.

Abstract: A scalable DLL (delay locked loop) circuit that has a calibration mechanism to auto tune locking precision. The delay locked loop circuit includes a multi-phase phase locked loop circuit for generating a plurality of phase signals according to a system clock, wherein one of the phase signals is a pixel clock; a phase detector for detecting an integral phase error and a fractional phase error between a reference signal and a feedback signal according to the pixel clock; a phase selector for selecting one of the phase signals according to the fractional phase error; and a delay circuit for shifting the phase of the reference signal according to the integral phase error and the selected phase signal to generate an output signal.

Abstract: The present invention provides therapeutically active compounds and compositions as NMDA and MC receptor antagonists, which are useful in preventing and treating central nervous system disorders by inhibiting over-activation of NMDA and/or MC receptors. In one aspect, the present invention provides methods of treating and/or preventing neurodegenerative diseases and neuropathological disorders, methods of providing neuroprotection under stress conditions such as a stroke, methods of enhancing the brain's cognitive functions and methods of treating depression, anxiety and cachexia induced by a chronic disease in mammals and humans.

Abstract: A scalable DLL (delay locked loop) circuit that has a calibration mechanism to auto tune locking precision. The delay locked loop circuit includes a multi-phase phase locked loop circuit for generating a plurality of phase signals according to a system clock, wherein one of the phase signals is a pixel clock; a phase detector for detecting an integral phase error and a fractional phase error between a reference signal and a feedback signal according to the pixel clock; a phase selector for selecting one of the phase signals according to the fractional phase error; and a delay circuit for shifting the phase of the reference signal according to the integral phase error and the selected phase signal to generate an output signal.

Abstract: The invention provides compositions and methods for generating a molecular profile of genomic DNA by hybridization of labeled nucleic acid representing the genomic DNA to immobilized nucleic acid probes, e.g., arrays or biochips.

Abstract: In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays, and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications, and the like, and the diagnosis or prognosis of syndromes associated with a contiguous gene abnormality. Kits are also provided.

Abstract: The invention provides biological molecules modified by reaction with a compound having the formula: R1—X—R2 , wherein R1 is a cyclic ether group or an amino group, R2 is an alkoxysilane group and X is a moiety chemically suitable for linking the cyclic ether group or the amino group to the alkoxysilane group. The invention also provides arrays, or “biochips,” comprising these modified biological molecules. Also provided are methods for making and using these compositions.

Abstract: The invention provides biological molecules modified by reaction with a compound having the formula: R1—X—R2, wherein R1 is a cyclic ether group or an amino group, R2 is an alkoxysilane group and X is a moiety chemically suitable for linking the cyclic ether group or the amino group to the alkoxysilane group. The invention also provides arrays, or “biochips,” comprising these modified biological molecules. Also provided are methods for making and using these compositions.

Abstract: A simplified strategy for sequencing large genomes has been developed. Clone-Array Pooled Shotgun Sequencing (CAPSS) is based upon pooling rows and columns of arrayed genomic clones, for shotgun library construction. Random sequences are accumulated and the data are assembled by sequential comparison of rows and columns, to resolve the sequence of clones at points of intersection. Compared to either a clone-by-clone approach or whole genome shotgun sequencing, CAPSS requires relatively few library constructions and only minimal computational power for a complete genome assembly. The strategy is suitable for sequencing large genomes for which there are no sequence-ready maps, but for which relatively high resolution STS maps and highly redundant BAC libraries are available. It is immediately applicable to the sequencing of mouse, rat, zebra fish and other important genomes, and can be managed in a cooperative fashion to take advantage of the distributed international DNA sequencing capacity.

Abstract: The invention relates to novel chemically modified biological molecules with enhanced lability towards solid supports, such as glass. These modified molecules can be readily affixed to solid supports, for instance, a glass surface, without first derivatizing the glass surface. High-density microarrays based on these modified molecules as well as methods for preparing these microarrays are also useful.

Abstract: The invention relates to novel chemically modified biological molecules with enhanced lability towards solid supports, such as glass. These modified molecules can be readily affixed to solid supports, for instance, a glass surface, without first derivatizing the glass surface. High-density microarrays based on these modified molecules as well as methods for preparing these microarrays are also useful.

Abstract: A steam vacuum cleaner comprising a vacuum cleaner and a steam mechanism, the present invention inhales dust and small particles, at the same time injects high temperature steam to soft and loose heavy stain and stubborn dirt for detailed cleaning and sterilization purpose.

Abstract: In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays, and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications, and the like, and the diagnosis or prognosis of syndromes associated with a contiguous gene abnormality. Kits are also provided.

Abstract: A simplified strategy for sequencing large genomes has been developed. Clone-Array Pooled Shotgun Sequencing (CAPSS) is based upon pooling rows and columns of arrayed genomic clones, for shotgun library construction. Random sequences are accumulated and the data are assembled by sequential comparison of rows and columns, to resolve the sequence of clones at points of intersection. Compared to either a clone-by-clone approach or whole genome shotgun sequencing, CAPSS requires relatively few library constructions and only minimal computational power for a complete genome assembly. The strategy is suitable for sequencing large genomes for which there are no sequence-ready maps, but for which relatively high resolution STS maps and highly redundant BAC libraries are available. It is immediately applicable to the sequencing of mouse, rat, zebra fish and other important genomes, and can be managed in a cooperative fashion to take advantage of the distributed international DNA sequencing capacity.

Abstract: The invention provides compositions and methods for generating a molecular profile of genomic DNA by hybridization of labeled nucleic acid representing the genomic DNA to immobilized nucleic acid probes, e.g., arrays or biochips.

Abstract: The invention provides biological molecules modified by reaction with a compound having the formula: R1—X—R2, wherein R1 is a cyclic ether group or an amino group, R2 is an alkoxysilane group and X is a moiety chemically suitable for linking the cyclic ether group or the amino group to the alkoxysilane group. The invention also provides arrays, or “biochips,” comprising these modified biological molecules. Also provided are methods for making and using these compositions.

Abstract: The invention provides compositions and methods for generating a molecular profile of genomic DNA by hybridization of labeled nucleic acid representing the genomic DNA to immobilized nucleic acid probes, e.g., arrays or biochips.