Patents by Inventor Wen Chean Lim

Wen Chean Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI TRBC1 ANTIGEN BINDING DOMAINS
    Publication number: 20230053849
    Abstract: The present disclosure relates to anti-TRBCl antigen binding domains characterized by the sequences of the variable chains. The CDRs sequences of the variable chains are: (VH CDR1) GYTFT, (VH CDR2) NPYNDDIQS, (VH CDR3) GAGY-NFDGAYRFFDF; and (VL CDR1) RSSQRLVHSNGNTYL, (VL CDR2) RVSNRFP, (VL CDR3) SQSTHVPYT. The claimed humanized antibodies derive from the murine JOVI antibody. Uses in cancer therapy.
    Type: Application
    Filed: August 3, 2022
    Publication date: February 23, 2023
    Inventors: Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Ram Jha, Wen Chean Lim
  • CHIMERIC ANTIGEN RECEPTOR
    Publication number: 20220356260
    Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease.
    Type: Application
    Filed: May 17, 2022
    Publication date: November 10, 2022
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Mathieu Ferrari, Wen Chean Lim, Biao Ma
  • Anti TRBC1 antigen binding domains
    Patent number: 11440961
    Abstract: The present disclosure relates to anti-TRBC1 antigen binding domains characterized by the sequences of the variable chains. The CDRs sequences of the variable chains are: (VH CDR1) GYTFT, (VH CDR2) NPYNDDIQS, (VH CDR3) GAGY-NFDGAYRFFDF; and (VL CDR1) RSSQRLVHSNGNTYL, (VL CDR2) RVSNRFP, (VL CDR3) SQSTHVPYT. The claimed humanized antibodies derive from the murine JOVI antibody. Uses in cancer therapy.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: September 13, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Ram Jha, Wen Chean Lim
  • Anti TRBC1 antigen binding domains
    Patent number: 11434293
    Abstract: The present disclosure relates to anti-TRBC1 antigen binding domains characterized by the sequences of the variable chains. The CDRs sequences of the variable chains are: (VH CDR1) GYTFT, (VH CDR2) NPYNDDIQS, (VH CDR3) GAGYNFDGAYRFFDF; and (VL CDR1) RSSQRLVHSNGNTYL, (VL CDR2) RVSNRFP, (VL CDR3) SQSTHVPYT. The claimed humanized antibodies derive from the murine JOVI antibody. Uses in cancer therapy.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: September 6, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Ram Jha, Wen Chean Lim
  • ANTI TRBC1 ANTIGEN BINDING DOMAINS
    Publication number: 20220098300
    Abstract: The present disclosure relates to anti-TRBC1 antigen binding domains characterized by the sequences of the variable chains. The CDRs sequences of the variable chains are: (VH CDR1) GYTFT, (VH CDR2) NPYNDDIQS, (VH CDR3) GAGY-NFDGAYRFFDF; and (VL CDR1) RSSQRLVHSNGNTYL, (VL CDR2) RVSNRFP, (VL CDR3) SQSTHVPYT. The claimed humanized antibodies derive from the murine JOVI antibody. Uses in cancer therapy.
    Type: Application
    Filed: October 12, 2021
    Publication date: March 31, 2022
    Inventors: Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Ram Jha, Wen Chean Lim
  • CHIMERIC ANTIGEN RECEPTOR
    Publication number: 20220033509
    Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease.
    Type: Application
    Filed: September 26, 2019
    Publication date: February 3, 2022
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Mathieu Feerari, Wen Chean Lim, Biao Ma
  • ANTI TRBC1 ANTIGEN BINDING DOMAINS
    Publication number: 20200140549
    Abstract: The present disclosure relates to anti-TRBC1 antigen binding domains characterized by the sequences of the variable chains. The CDRs sequences of the variable chains are: (VH CDR1) GYTFT, (VH CDR2) NPYNDDIQS, (VH CDR3) GAGYNFDGAYRFFDF; and (VL CDR1) RSSQRLVHSNGNTYL, (VL CDR2) RVSNRFP, (VL CDR3) SQSTHVPYT. The claimed humanized antibodies derive from the murine JOVI antibody. Uses in cancer therapy.
    Type: Application
    Filed: June 8, 2018
    Publication date: May 7, 2020
    Inventors: Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Ram Jha, Wen Chean Lim
  • CELL EXPRESSING A CAR AND A TRANSCRIPTION FACTOR AND ITS USE
    Publication number: 20200030379
    Abstract: The present invention provides a cell which comprises a first exogenous nucleic acid molecule encoding a Chimeric Antigen Receptor (CAR) and a second exogenous nucleic acid molecule encoding a transcription factor.
    Type: Application
    Filed: December 20, 2017
    Publication date: January 30, 2020
    Inventors: Martin Pulé, Simon Thomas, Shaun Cordoba, Wen Chean Lim