Patents by Inventor Wen-Cherng Lee

Wen-Cherng Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic aryl sphingosine 1-phosphate analogs
    Publication number: 20100160258
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Application
    Filed: October 30, 2009
    Publication date: June 24, 2010
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel, Wen-Cherng Lee, Edward Yin-Shiang Lin, Xiaogao Liu, Bin Ma, Daniel M. Scott, Zhan Shi, Jermaine Thomas, Arthur G. Taveras, Guo Zhu Zheng
  • PYRIDINONYL PDK1 INHIBITORS
    Publication number: 20100144730
    Abstract: The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.
    Type: Application
    Filed: July 2, 2007
    Publication date: June 10, 2010
    Applicants: Sunesis Phamaceuticals, Biogen IDEC,INC
    Inventors: Kenneth Egnard Lind, Kathy Cao, Edward Yin-shiang Lin, Thinh Ba Nguyen, Bradley T. Tangonan, Daniel A. Erlanson, Kevin Guckian, Robert Lowell Simmons, Wen-cherng Lee, Lihong Sun, Stig Hansen, Nuzhat Pathan, Lei Zhang
  • Furanone Compounds and Methods of Making and Using The Same
    Publication number: 20100105714
    Abstract: The invention features compounds of the general Formula (I): (formula should be inserted here) Compounds of Formula (I) possess unexpectedly high affinity for Alk5 and/or Alk4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.
    Type: Application
    Filed: January 30, 2008
    Publication date: April 29, 2010
    Applicant: Biogen Idec MA Inc.
    Inventors: Lihong Sun, Wen-Cherng Lee, Paul Lyne
  • Pyrazolopyridines and methods of making and using the same
    Patent number: 7691865
    Abstract: Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: April 6, 2010
    Assignee: Biogen Idec MA Inc.
    Inventors: Wen-Cherng Lee, Mary Beth Carter, Lihong Sun, Paul Lyne, Claudio Chuaqui, Zhongli Zheng, Juswinder Singh, Paula Boriack-Sjodin
  • Substituted Pyrazalones
    Publication number: 20100056505
    Abstract: The invention is related to compounds of formula (I) as antagonists of the TGF? family type I receptors, Alk5 and/or AIk 4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGF? family signaling activity is desirable.
    Type: Application
    Filed: November 21, 2006
    Publication date: March 4, 2010
    Inventors: Wen-Cherng Lee, Mary Beth Carter, Claudio Chuaqui, Kevin Guckian, Edward Lin, Michael J. Choi, Zhan Deng, Paula Ann Boriack-Sjodin, Lihong Sun
  • Imidazolone Compounds and Methods of Making and Using the Same
    Publication number: 20100035918
    Abstract: In one aspect, the invention features a compound of the general Formula (I). Compounds of Formula (I) possess high affinity for Alk 5 and/or AIk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.
    Type: Application
    Filed: January 30, 2008
    Publication date: February 11, 2010
    Applicant: Biogen Idec MA Inc
    Inventors: Kevin Guckian, Wen-Cherng Lee, Edward Lin
  • Tri-substituted heteroaryls and methods of making and using the same
    Patent number: 7612094
    Abstract: Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of the general formula (I).
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: November 3, 2009
    Assignee: Biogen Idec MA Inc.
    Inventors: Wen-Cherng Lee, Lihong Sun, Feng Shan, Claudio Chuaqui, Zhongli Zheng, Russell C. Petter
  • Pyrimidinylpyrazoles as Tgf-Beta Inhibitors
    Publication number: 20080171755
    Abstract: The invention is based on the discovery that compounds of formula (I) possess high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. The invention features a compound of formula (I) and uses thereof: formula (I).
    Type: Application
    Filed: August 24, 2005
    Publication date: July 17, 2008
    Inventors: Wen-Cherng Lee, Lihong Sun, Claudio Chuaqui, Mark Comebise, Juswinder Singh, Feng Shan
  • Cell adhesion inhibitors
    Patent number: 7196112
    Abstract: Cell adhesion inhibitors can interact with VLA-4 molecules and inhibits VLA-4 dependent cell adhesion. An inhibitor including a polyethylene glycol moiety can have advantageous pharmaceutical properties.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: March 27, 2007
    Assignee: Biogen Idec MA Inc.
    Inventors: Wen-Cherng Lee, R. Blake Pepinsky, Mark Cornebise, Daniel Scott, Russell C. Petter
  • Cell adhesion inhibitors
    Publication number: 20070066533
    Abstract: Cell adhesion inhibitors can interact with VLA-4 molecules and inhibits VLA-4 dependent cell adhesion. An inhibitor including a polyethylene glycol moiety can have advantageous pharmaceutical properties.
    Type: Application
    Filed: November 16, 2006
    Publication date: March 22, 2007
    Inventors: Wen-Cherng Lee, R. Pepinsky, Mark Cornebise, Daniel Scott, Russell Petter
  • Pyrazoles and methods of making and using the same
    Publication number: 20060264440
    Abstract: The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).
    Type: Application
    Filed: February 12, 2004
    Publication date: November 23, 2006
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Wen-Cherng Lee, Lihong Sun, Feng Shan, Claudio Chuaqui, Mark Cornebise, Timothy Pontz, Mary Carter, Juswinder Singh, Paula Boriack-Sjodin, Leona Ling, Russell Petter
  • Cell adhesion inhibitors
    Publication number: 20060166866
    Abstract: The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
    Type: Application
    Filed: October 7, 2003
    Publication date: July 27, 2006
    Inventors: Steven Adams, Ko-Chung Lin, Wen-Cherng Lee, Alfredo Castro, Craig Zimmerman, Charles Hammond, Yu-Sheng Liao, Julio Cuervo, Juswinder Singh
  • Cell adhesion inhibitors
    Publication number: 20060166961
    Abstract: A cell adhesion inhibitor of the general formula: R3-L-L?-R1 is disclosed. An inhibitor of the present invention interacts with VLA-4 molecules and inhibits VLA-4 dependent cell adhesion. Also disclosed are methods for preparing and using such a cell adhesion inhibitor, as well as pharmaceutical compositions containing the same.
    Type: Application
    Filed: February 27, 2006
    Publication date: July 27, 2006
    Applicant: Biogen Idec MA Inc.
    Inventors: Daniel Scott, Wen-Cherng Lee, Russell Petter, Mark Cornebise
  • Imidazolopyridines and methods of making and using the same
    Publication number: 20060135517
    Abstract: Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.
    Type: Application
    Filed: September 5, 2003
    Publication date: June 22, 2006
    Inventors: Wen-Cherng Lee, Mary Carter, Lihong Sun, Claudio Chuaqui, Juswinder Singh, Paula Boriack-Sjodin, Michael Choi
  • Pyrazolopyridines and methods of making and using the same
    Publication number: 20060106033
    Abstract: Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.
    Type: Application
    Filed: September 5, 2003
    Publication date: May 18, 2006
    Inventors: Wen-Cherng Lee, Mary Carter, Lihong Sun, Claudio Chuaqui, Zhongli Zheng, Juswinder Singh, Paula Boriack-Sjodin, Paul Lyne
  • Cell adhesion inhibitors
    Patent number: 7034043
    Abstract: A cell adhesion inhibitor of the general formula: R3-L-L?-R1 is disclosed. An inhibitor of the present invention interacts with VLA-4 molecules and inhibits VLA-4 dependent cell adhesion. Also disclosed are methods for preparing and using such a cell adhesion inhibitor, as well as pharmaceutical compositions containing the same.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: April 25, 2006
    Assignee: Biogen Idec MA Inc.
    Inventors: Daniel Scott, Wen-Cherng Lee, Russell C. Petter, Mark Cornebise
  • Tri-substituted heteroaryls and methods of making and using the same
    Publication number: 20060063809
    Abstract: Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of the general formula (I).
    Type: Application
    Filed: April 4, 2003
    Publication date: March 23, 2006
    Inventors: Wen-Cherng Lee, Lihong Sun, Feng Shan, Claudio Chuaqui, Zhongli Zheng, Russell Petter
  • Cell adhesion inhibitors
    Patent number: 7001921
    Abstract: The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: February 21, 2006
    Assignee: Biogen Idec MA Inc.
    Inventors: Steven P. Adams, Ko-Chung Lin, Wen-Cherng Lee, Alfredo C. Castro, Craig N. Zimmerman, Charles E. Hammond, Yu-Sheng Liao
  • Cell adhesion inhibitors
    Publication number: 20060014966
    Abstract: Cell adhesion inhibitors can interact with VLA-4 molecules and inhibits VLA-4 dependent cell adhesion. An inhibitor including a polyethylene glycol moiety can have advantageous pharmaceutical properties.
    Type: Application
    Filed: July 16, 2004
    Publication date: January 19, 2006
    Inventors: Wen-Cherng Lee, R. Pepinsky, Mark Cornebise, Daniel Scott, Russell Petter
  • Cell adhesion inhibitors
    Patent number: 6875743
    Abstract: The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: April 5, 2005
    Assignee: Biogen, Inc.
    Inventors: Ko-Chung Lin, Steven P. Adams, Alfredo C. Castro, Craig N. Zimmerman, Julio Hernan Cuervo, Wen-Cherng Lee, Charles E. Hammond, Mary Beth Carter, Ronald G. Almquist