Patents by Inventor Wen-Chung Shieh

Wen-Chung Shieh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
    Patent number: 9163005
    Abstract: Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: October 20, 2015
    Assignee: Novartis AG
    Inventors: Paul W Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr H Karpinski, Raeann Wu, Stéphanie Monnier, Jörg Brozio
  • Process for the synthesis of 5-(methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzeneamine
    Patent number: 8946416
    Abstract: The present invention provides a new method of making compounds of formula (I): wherein R1 is mono- or polysubstituted aryl; R2 is hydrogen, lower alkyl or aryl; and R4 is hydrogen, lower alkyl or halogen.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: February 3, 2015
    Assignee: Novartis AG
    Inventors: Wen-Chung Shieh, Joseph McKenna
  • Crystalline Forms of 4-Methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
    Publication number: 20140343087
    Abstract: Crystalline forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base and salts thereof are prepared by various processes.
    Type: Application
    Filed: August 1, 2014
    Publication date: November 20, 2014
    Applicant: Novartis AG
    Inventors: Paul W. Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr H. Karpinski, Raeann Wu, Stéphanie Monnier, Jörg Brozio
  • Crystalline forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
    Patent number: 8829015
    Abstract: Crystalline forms of 4-methyl-N-3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base and salts thereof are prepared by various processes.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: September 9, 2014
    Assignee: Novartis AG
    Inventors: Paul W. Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr “Peter” H. Karpinski, Raeann Wu, Stephanie Monnier, Jörg Brozio
  • Salts of 4-Methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
    Publication number: 20140038994
    Abstract: Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes.
    Type: Application
    Filed: October 11, 2013
    Publication date: February 6, 2014
    Applicant: Novartis AG
    Inventors: Paul W. MANLEY, Wen-Chung SHIEH, Paul Allen SUTTON, Piotr H. KARPINSKI, Raeann WU, Stéphanie MONNIER, Jörg BROZIO
  • Salts of 4-methyl N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
    Patent number: 8580806
    Abstract: Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: November 12, 2013
    Assignee: Novartis AG
    Inventors: Paul W Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr H Karpinski, Raeann Wu, Stéphanie Monnier, Jörg Brozio
  • Crystalline forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
    Patent number: 8415363
    Abstract: Crystalline forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base and salts thereof are prepared by various processes.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: April 9, 2013
    Assignee: Novartis AG
    Inventors: Paul W Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr “Peter” H Karpinski, Raeann R Wu, Stéphanie M Monnier, Jörg Brozio
  • Salts of 4-methyl N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
    Patent number: 8389537
    Abstract: Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: March 5, 2013
    Assignee: Novartis AG
    Inventors: Paul W Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr H Karpinski, Raeann Wu, Stéphanie Monnier, Jörg Brozio
  • Crystalline Forms of 4-Methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
    Publication number: 20130023548
    Abstract: Crystalline forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base and salts thereof are prepared by various processes.
    Type: Application
    Filed: August 3, 2012
    Publication date: January 24, 2013
    Inventors: Paul W. MANLEY, Wen-Chung SHIEH, Paul Allen SUTTON, Piotr H. KARPINSKI, Raeann WU, Stéphanie MONNIER, Jörg BROZIO
  • Crystalline forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
    Patent number: 8343984
    Abstract: Polymorphic forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base and salts thereof are prepared by various processes.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: January 1, 2013
    Assignees: Novartis AG, Novartis Pharma GmbH
    Inventors: Paul W Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr “Peter” H Karpinski, Raeann Wu, Stéphanie M. Monnier, Jörg Brozio
  • Salts of 4-Methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
    Publication number: 20120270891
    Abstract: Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes.
    Type: Application
    Filed: March 13, 2012
    Publication date: October 25, 2012
    Inventors: Paul W. Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr H. Karpinski, Raeann Wu, Stéphanie Monnier, Jörg Brozio
  • Process for the Synthesis of 5-(Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzeneamine
    Publication number: 20120116081
    Abstract: The present invention provides a new method of making compounds of formula (I): wherein R1 is mono- or polysubstituted aryl; R2 is hydrogen, lower alkyl or aryl; and R4 is hydrogen, lower alkyl or halogen.
    Type: Application
    Filed: January 19, 2012
    Publication date: May 10, 2012
    Inventors: Wen-Chung SHIEH, Joseph McKENNA
  • Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-Benzamide
    Patent number: 8163904
    Abstract: Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: April 24, 2012
    Assignees: Novartis AG, Novartis Pharma GmbH
    Inventors: Paul W Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr H Karpinski, Raeann Wu, Stéphanie Monnier, Jörg Brozio
  • Process for the synthesis of 5-(methyl-1-imidazol-1-yl)-3-(trifluoromethyl)-benzeneamine
    Patent number: 8124763
    Abstract: The present invention provides a new method of making compounds of formula (I): wherein R1 is mono- or polysubstituted aryl; R2 is hydrogen, lower alkyl or aryl; and R4 is hydrogen, lower alkyl or halogen.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: February 28, 2012
    Assignee: Novartis AG
    Inventors: Wen-Chung Shieh, Joseph McKenna
  • Process for the synthesis of organic compounds
    Patent number: 8008504
    Abstract: The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: August 30, 2011
    Assignee: Novartis AG
    Inventors: Stephan Abel, Murat Acemoglu, Bernhard Erb, Christoph Krell, Joseph Sclafani, Mark Meisenbach, Mahavir Prashad, Wen-Chung Shieh, Song Xue
  • PROCESS FOR THE SYNTHESIS OF ORGANIC COMPOUNDS
    Publication number: 20100280257
    Abstract: The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):
    Type: Application
    Filed: July 12, 2010
    Publication date: November 4, 2010
    Inventors: Stephan Abel, Murat Acemoglu, Bernhard Erb, Christoph Krell, Joseph Sclafani, Mark Meisenbach, Mahavir Prashad, Wen-Chung Shieh, Song Xue
  • Process for the synthesis of organic compounds
    Patent number: 7781597
    Abstract: The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: August 24, 2010
    Assignee: Novartis AG
    Inventors: Stephan Abel, Murat Acemoglu, Bernhard Erb, Christoph Krell, Joseph Sclafani, Mark Meisenbach, Mahavir Prashad, Wen-Chung Shieh, Song Xue
  • NANOPARTICLE COMPOSITIONS
    Publication number: 20100166865
    Abstract: A method of Nanoparticle-based therapy for a mammalian subject is disclosed. The method uses Nanoparticles and/or Nanoparticles with outer surfaces that contain an affinity moiety effective to bind specifically to a biological surface at which the therapy is aimed, and a hydrophilic polymer coating. The hydrophilic polymer coating is made up of polymer chains either covalently linked or surface adsorbed to the polymer components.
    Type: Application
    Filed: August 15, 2007
    Publication date: July 1, 2010
    Applicant: NOVARTIS AG
    Inventors: Saran Kumar, Wen-Chung Shieh, Seema Tomer, Joseph Lawrence Zielinski
  • Process for the synthesis of organic compounds
    Patent number: 7709657
    Abstract: The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is an intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: May 4, 2010
    Assignee: Novartis AG
    Inventors: Murat Acemoglu, Berthold Schenkel, Wen-Chung Shieh, Song Xue, Erich Widmer, Pedro Garcia Fuentes, Jose Martin Medina, Francisco Vicente Baños
  • Crystalline Forms of 4-Methyl-N- [3-(4-Methyl-Imidazol-1-Yl)-5-Trifluoromethyl-Phenyl]-3- (4-Pyridin-3-Yl-Pyrimidin-2-Ylamino) -Benzamide
    Publication number: 20080269269
    Abstract: Polymorphic forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base and salts thereof are prepared by various processes.
    Type: Application
    Filed: July 18, 2006
    Publication date: October 30, 2008
    Inventors: Paul W. Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr H. Karpinski, Raeann Wu, Stephanie Monnier, Jorg Brozio