Patents by Inventor Wen H. Wu
Wen H. Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7166234Abstract: A composition, method, and device for quantitatively determining the concentration of a dialdehyde in a sample are disclosed. The device includes a test pad having a suitable carrier matrix incorporating an indicator reagent composition capable of interacting with a dialdehyde to produce a detectable and measurable response for dialdehyde concentration over a range of 0% to about 20%, by weight of the sample. An indicator reagent composition contains: (a) a diamino carboxylic acid, (b) an optional polymer and (c) a carrier. An indicator reagent composition is incorporated into a carrier matrix to provide a test pad useful in a dry phase dialdehyde assay of a sample, especially for samples containing a high concentration of glutaraldehyde.Type: GrantFiled: October 26, 2000Date of Patent: January 23, 2007Assignee: Integrated Biomedical Technology, Inc.Inventor: Wen H. Wu
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Patent number: 6436716Abstract: A composition, method, and device for quantitatively determining the concentration of an aldehyde in a sample are disclosed. The device includes a test pad having a suitable carrier matrix incorporating an indicator reagent composition capable of interacting with the aldehyde to produce a detectable and measurable response for aldehyde concentration over a range of 0% to over 4%, by weight of the sample. An indicator reagent composition contains: (a) a protein, (b) an amine, (c) a color indicator, (d) preferably a neutral, nonionic polymer, such as a water-soluble cellulose polymer, and (e) a carrier. An indicator reagent composition is incorporated into a carrier matrix, like filter paper, to provide a test pad useful in a dry phase aldehyde assay of a sample, especially for samples containing a high concentration of glutaraldehyde or formaldehyde.Type: GrantFiled: May 30, 2000Date of Patent: August 20, 2002Assignee: Integrated Biomedical Technology, Inc.Inventor: Wen H. Wu
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Patent number: 6087089Abstract: A composition, method, and test device for quantitatively determining the oxidant concentration of a test sample are disclosed. The test device includes a test pad having a suitable carrier matrix incorporating an indicator reagent composition capable of interacting with an oxidant to produce a detectable and measurable response for oxidant over a wide concentration range of oxidant. An indicator reagent composition contains: (a) an iodide salt, (b) a buffer, and (c) a water-soluble polymer, preferably a cellulose-based polymer. An indicator reagent composition is incorporated into a carrier matrix, like filter paper, to provide a test pad useful in a dry phase oxidant assay of a test sample, especially for test samples containing a high concentration of oxidant, like chlorine or a peroxide.Type: GrantFiled: June 2, 1998Date of Patent: July 11, 2000Assignee: Integrated Biomedical Technology, Inc.Inventor: Wen H. Wu
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Patent number: 5976823Abstract: A composition, method, and test device for determining a low concentration of total available chlorine concentration in a test sample are disclosed. The test device includes a test pad having a suitable carrier matrix incorporating an indicator reagent composition capable of converting combined available chlorine to free available chlorine and of interacting with free available chlorine to produce a detectable and measurable response for total available chlorine over a range of 0 to about 2 ppm total available chlorine in the test sample. An indicator reagent composition contains: (a) an indicator dye that is responsive to free available chlorine, such as tetramethylbenzidine, (b) a buffer, (c) an optional surfactant, (d) a catalyst, and (e) a polymer. An indicator reagent composition is incorporated into a carrier matrix, like filter paper, to provide a test pad useful in a dry phase total available chlorine assay of a test sample, such as a source water for a hemodialysis unit.Type: GrantFiled: February 23, 1999Date of Patent: November 2, 1999Assignee: Integrated Biomedical Technology, Inc.Inventor: Wen H. Wu
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Patent number: 5906916Abstract: A composition, method, and test device for quantitatively determining the peroxide concentration of a test sample are disclosed. The test device includes a test pad having a suitable carrier matrix incorporating an indicator reagent composition capable of interacting with peroxide to produce a detectable and measurable response for peroxide over a range of 0% to over 4%, by weight of the test sample. An indicator reagent composition contains: (a) an iodide salt, (b) a buffer, and (c) a water-soluble polymer, preferably a cellulose-based polymer. An indicator reagent composition is incorporated into a carrier matrix, like filter paper, to provide a test pad useful in a dry phase peroxide assay of a test sample, especially for test samples containing a high concentration of peroxide.Type: GrantFiled: November 12, 1997Date of Patent: May 25, 1999Assignee: Integrated Biomedical Technology Inc.Inventor: Wen H. Wu
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Patent number: 5888758Abstract: A composition, method, and test device for determining the total available chlorine concentration, and the relative amounts of free and bound chlorine, of a test sample are disclosed. The test device includes a test pad having a suitable carrier matrix incorporating an indicator reagent composition capable of converting combined available chlorine to free available chlorine and of interacting with free available chlorine to produce a detectable and measurable response for total available chlorine over a range of 0 to over 5000 ppm total available chlorine in the test sample. An indicator reagent composition contains: (a) an indicator dye that is responsive to free available chlorine, such as tetramethylbenzidine, (b) a buffer, (c) a surfactant, (d) an optional catalyst, and (e) an optional polymer.Type: GrantFiled: February 18, 1998Date of Patent: March 30, 1999Assignee: Integrated Biomedical Technology, Inc.Inventor: Wen H. Wu
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Patent number: 5811254Abstract: A composition, method, and test device for determining the total available chlorine concentration of a test sample are disclosed. The test device includes a test pad having a suitable carrier matrix incorporating an indicator reagent composition capable of converting combined available chlorine to free available chlorine and of interacting with free available chlorine to produce a detectable and measurable response for total available chlorine over a range of 0 to over 5000 ppm total available chlorine in the test sample. An indicator reagent composition contains: (a) an indicator dye that is responsive to free available chlorine, such as tetramethylbenzidine, (b) a buffer, (c) a surfactant, (d) an optional catalyst, and (e) an optional polymer. An indicator reagent composition is incorporated into a carrier matrix, like filter paper, to provide a test pad useful in a dry phase total available chlorine assay of a test sample, such as a sanitizing solution for a hemodialysis unit.Type: GrantFiled: March 19, 1997Date of Patent: September 22, 1998Assignee: Integrated Biomedical Technology, Inc.Inventor: Wen H. Wu
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Patent number: 5217691Abstract: The invention provides a nonenzymatic method useful for the semiquantitative determination of glucose, a test composition and test device. Glucose concentration in an aqueous test sample can be determined by preparing a test solution by contacting an aqueous test sample and a dihydroxide component, at an initial pH above 6.5, capable of forming a complex with glucose which complex formation releases a proton, and determining the final pH of the test solution. The invention also provides a self-indicating device format which allows the determination of glucose concentration by merely counting the number of pads which have changed color. No comparison to a color chart is required. The glucose test of the present invention is free of the interferences found in enzymatic glucose tests.Type: GrantFiled: May 4, 1992Date of Patent: June 8, 1993Assignee: Miles Inc.Inventors: Carmine Greene, Ibrahim A. Ismail, Wen H. Wu
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Patent number: 5185247Abstract: A method and composition for the enzymatic assay of a liquid test sample, such as urine or serum, for a specific analyte, such as glucose. The method utilizes a dry phase test strip comprising a carrier matrix impregnated with a stabilized enzyme reagent composition including an oxidase enzyme, such as glucose oxidase, that is capable of interacting with the analyte of interest; a chromogen that changes color in response to the analyte-oxidase enzyme interaction to reveal the presence and/or concentration of the analyte in the test sample; and a stabilizer, such as a hydrazide, like GIRARD'S Reagent T, or an amino acid, like arginine, or an amino acid derivative, like the tris(hydroxymethyl)aminomethane sale of glutamic acid, to improve the heat stability and shelf life of the dry phase test strip.Type: GrantFiled: February 25, 1992Date of Patent: February 9, 1993Assignee: Miles Inc.Inventors: Ibrahim A. Ismail, Wen H. Wu
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Patent number: 5116729Abstract: A method and composition for the enzymatic assay of liquid test sample, such as urine or serum, for a specific analyte, such as glucose. The method utilizes a dry phase test strip comprising a carrier matrix impregnated with a stabilized enzyme reagent composition including an oxidase enzyme, such as glucose oxidase, that is capable of interacting with the analyte of interest; a chromogen that changes color in response to the analyte-oxidase enzyme interaction to reveal the presence and/or concentration of the analyte in the test sample; and a stabilizer, such as a hydrazide, like GIRARD'S Reagent T, or an amino acid, like arginine, or an amino acid derivative, like the tris(hydroxymethyl)aminomethane salt of glutamic acid, to improve the heat stability and shelf life of the dry phase test strip.Type: GrantFiled: March 10, 1989Date of Patent: May 26, 1992Assignee: Miles Inc.Inventors: Ibrahim A. Ismail, Wen H. Wu
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Patent number: 5116763Abstract: The invention provides a nonenzymatic method useful for the semiquantitative determination of glucose, a test composition and test device. Glucose concentration in an aqueous test sample can be determined by preparing a test solution by contacting an aqueous test sample and a dihydroxide component, at an initial pH above 6.5, capable of forming a complex with glucose which complex formation releases a proton, and determining the final pH of the test solution. The invention also provides a self-indicating device format which allows the determination of glucose concentration by merely counting the number of pads which have changed color. No comparison to a color chart is required. The glucose test of the present invention is free of the interferences found in enzymatic glucose tests.Type: GrantFiled: October 13, 1988Date of Patent: May 26, 1992Assignee: Miles Inc.Inventors: Carmine Greene, Ibrahim A. Ismail, Wen H. Wu