Abstract: Methods to treat cancer in a subject comprising administering to the subject a therapeutically effective amount of T-cells of the subject having increased IRF4 polypeptide expression compared to a control are disclosed. Also disclosed are methods of increasing tumor reactivity of a T-cell by increasing IRF4 polypeptide expression, and methods to predict the likelihood that a subject having cancer will respond therapeutically to administered T-cells having increased IRF4 polypeptide expression. Also disclosed are compositions comprising a T-cell and a viral vector encoding an IRF4 polypeptide. The compositions are methods are useful for treating numerous cancers in which higher level expression of IRF4 in T-cells would be beneficial. In some embodiments, activated tumor-specific T-cells having increased IRF4 expression have greater infiltration in tumors and enhanced local immunological responses.

Abstract: A physical unclonable functions (PUF) device including a first copper electrode, a second electrode, and a silicon oxide layer positioned directly between the first copper electrode and the second electrode; a method of producing a PUF device; an array comprising a PUF device; and a method of generating a secure key with a plurality of PUF devices.

Abstract: Methods to treat cancer in a subject comprising administering to the subject a therapeutically effective amount of T-cells of the subject having increased IRF4 polypeptide expression compared to a control are disclosed. Also disclosed are methods of increasing tumor reactivity of a T-cell by increasing IRF4 polypeptide expression, and methods to predict the likelihood that a subject having cancer will respond therapeutically to administered T-cells having increased IRF4 polypeptide expression. Also disclosed are compositions comprising a T-cell and a viral vector encoding an IRF4 polypeptide. The compositions are methods are useful for treating numerous cancers in which higher level expression of IRF4 in T-cells would be beneficial. In some embodiments, activated tumor specific T-cells having increased IRF4 expression have greater infiltration in tumors and enhanced local immunological responses.

Abstract: A method for calibrating a downhole tool may comprise disposing a downhole tool in a borehole, transmitting a signal from a master module disposed on the first device to a module disposed on the second device, transmitting a return signal from the module to the master module, receiving the return signal with the master module, measuring a tone enabled delay for the signal to travel from the master module to the module, and determining a time delay of a return signal to travel from the module to the master module. A well measurement system may comprise a downhole tool. The downhole tool may further comprise a first device and a master module disposed on the first device, wherein the master module may comprise a master transmitter and a master receiver. In examples, the downhole tool may further comprise a second device and a module disposed on the second device.

Abstract: A physical unclonable functions (PUF) device including a first copper electrode, a second electrode, and a silicon oxide layer positioned directly between the first copper electrode and the second electrode; a method of producing a PUF device; an array comprising a PUF device; and a method of generating a secure key with a plurality of PUF devices.

Abstract: Embodiments of this application provide a mobile terminal, relate to the field of sound on screen technologies. At least a part of a vibrator in the mobile terminal is disposed in an accommodation cavity. The vibrator includes a first magnet, a second magnet, a coil, and at least one third magnet. The first magnet, the coil, and the third magnet are all connected to a rear face of a display module. The first magnet is located in a closed region enclosed by a conducting wire of the coil. The third magnet is located on one side that is of the coil and that is away from the first magnet. The second magnet is connected to a middle frame, and a location of the second magnet and a location of the first magnet are disposed opposite each other.

Abstract: Embodiments disclosed herein represent powder based additive manufacturing processes which provide a microstructure having improved mechanical properties. The methods may include the use of ultrasonic excitation in combination with the active control of a substrate's temperature to provide some level of control over the microstructure and hence the properties.

Abstract: A method and apparatus for generating information are disclosed. An implementation of the method includes: receiving a target text, the target text including an objective and descriptive information of the objective; performing a dependency syntax parsing on the target text to generate a dependency tree of the target text; matching predetermined syntactic structure tree with the dependency tree to obtain at least one triple, a triple including a subject, a predicate, and an object; and determining, based on words contained in a triple among the at least one triple and a predetermined weight of the syntactic structure tree matched to obtain the triple, a target triple among the at least one triple.

Abstract: A physical unclonable functions (PUF) device including a first copper electrode, a second electrode, and a silicon oxide layer positioned directly between the first copper electrode and the second electrode; a method of producing a PUF device; an array comprising a PUF device; and a method of generating a secure key with a plurality of PUF devices.

Abstract: A continuous production device and method for a silane-modified sealing material are provided. The device includes a twin screw extruder set, a cooling unit, and a static mixing unit; where the twin screw extruder set includes at least two twin screw extruders in series, each of which is provided with at least two inlets and at least one vacuum port, the cooling unit is disposed between last two stages of the twin screw extruders, and an outlet of a last-stage twin screw extruder is connected to the static mixing unit.

Abstract: A method and an apparatus for event detection, a device, and a storage medium. An event is formed by acquiring a plurality of texts including a target keyword; extracting phrases independently describing event information from titles of the plurality of texts; and clustering the extracted phrases and gathering texts where phrases belonging to a same cluster are located to form an event. The accuracy of the event detection and the recall rate for an event can be improved through the method provided by embodiments of the present application.

Abstract: Disclosed are methods and compositions for inhibiting IRF4 in T-cells, thereby improving transplant outcomes or treating an autoimmune disease such as a myelination disorder. Thus, disclosed are methods to improve a transplant outcome in a recipient of a transplant comprising inhibiting IRF4 in T-cells of the recipient, thereby improving the transplant outcome. In some embodiments, IRF4 can be inhibited by administering an IRF4 inhibitor (e.g., trametinib or anti-IRF4 siRNA), and/or by adoptive transfer of T-cells having IRF4 inhibition. In some embodiments, the T-cells are CD4+ Tcells, and the infiltration thereof into a transplant can be reduced. Also disclosed are methods of treating a subject with a myelination disorder (e.g., multiple sclerosis or encephalomyelitis) comprising inhibiting IRF4.

Abstract: A method for calibrating a downhole tool may comprise disposing a downhole tool in a borehole, transmitting a signal from a master module disposed on the first device to a module disposed on the second device, transmitting a return signal from the module to the master module, receiving the return signal with the master module, measuring a tone enabled delay for the signal to travel from the master module to the module, and determining a time delay of a return signal to travel from the module to the master module. A well measurement system may comprise a downhole tool. The downhole tool may further comprise a first device and a master module disposed on the first device, wherein the master module may comprise a master transmitter and a master receiver. In examples, the downhole tool may further comprise a second device and a module disposed on the second device.

Abstract: A physical unclonable functions (PUF) device including a first copper electrode, a second electrode, and a silicon oxide layer positioned directly between the first copper electrode and the second electrode; a method of producing a PUF device; an array comprising a PUF device; and a method of generating a secure key with a plurality of PUF devices.

Abstract: Methods to treat cancer in a subject comprising administering to the subject a therapeutically effective amount of T-cells of the subject having increased IRF4 polypeptide expression compared to a control are disclosed. Also disclosed are methods of increasing tumor reactivity of a T-cell by increasing IRF4 polypeptide expression, and methods to predict the likelihood that a subject having cancer will respond therapeutically to administered T-cells having increased IRF4 polypeptide expression. Also disclosed are compositions comprising a T-cell and a viral vector encoding an IRF4 polypeptide. The compositions are methods are useful for treating numerous cancers in which higher level expression of IRF4 in T-cells would be beneficial. In some embodiments, activated tumor specific T-cells having increased IRF4 expression have greater infiltration in tumors and enhanced local immunological responses.

Abstract: A physical unclonable functions (PUF) device including a first copper electrode, a second electrode, and a silicon oxide layer positioned directly between the first copper electrode and the second electrode; a method of producing a PUF device; an array comprising a PUF device; and a method of generating a secure key with a plurality of PUF devices.

Abstract: A method and an apparatus for event detection, a device, and a storage medium. An event is formed by acquiring a plurality of texts including a target keyword; extracting phrases independently describing event information from titles of the plurality of texts; and clustering the extracted phrases and gathering texts where phrases belonging to a same cluster are located to form an event. The accuracy of the event detection and the recall rate for an event can be improved through the method provided by embodiments of the present application.

Abstract: A method and apparatus for generating information are disclosed. An implementation of the method includes: receiving a target text, the target text including an objective and descriptive information of the objective; performing a dependency syntax parsing on the target text to generate a dependency tree of the target text; matching predetermined syntactic structure tree with the dependency treeto obtain at least one triple, a triple including a subject, a predicate, and an object; and determining, based on words contained in a triple among the at least one triple and a predetermined weight of the syntactic structure tree matched to obtain the triple, a target triple among the at least one triple.

Abstract: Embodiments disclosed herein represent powder based additive manufacturing processes which provide a microstructure having improved mechanical properties. The methods may include the use of ultrasonic excitation in combination with the active control of a substrate's temperature to provide some level of control over the microstructure and hence the properties.

Abstract: A pharmaceutical composition is provided having particles of a physical mixture that contain at least one 20-camptothecin or a derivative thereof, at least one surfactant, at least one stabilizer, and at least one diluent. The particles have a mean particle size of less than about 2500 nm. The pharmaceutical composition can be nano- or micro-sized particles containing the 20-camptothecin esters or derivatives thereof as part of a physical mixture, which can provide the active compound in a water-soluble/dispersible, bioavailable form. The particles can be used as an oral pharmaceutical composition which comprises the nano- or micro-sized form of 20-camptothecin esters or derivatives, such as in an oral suspension (e.g., an aqueous suspension), or capsules, or caplets. The pharmaceutical composition can be used in the treatment of a cancer or malignant tumor in a patient by oral administration thereof in a therapeutically effective amount.