Abstract: A thermoplastic elastomer composition for crosslinked foam and the manufacturing method thereof are provided. The thermoplastic elastomer composition comprising (A) an ethylene-based copolymer; (B) a first copolymer; (C) a second copolymer, wherein the component (B) and (C) are copolymers comprising a vinyl aromatic monomer and a conjugated diene monomer, the first copolymer having a conjugated diene hydrogenation rate of at least 80% and the second copolymer having a conjugated diene hydrogenation rate of no more than 10%; (D) an organic peroxide; and (E) a foaming agent, wherein a mass ratio (A/(B+C)) of the component (A) to a combination of the component (B) and the component (C) is 95/5 to 5/95; and a mass ratio (B/C) of the component (B) to the component (C) is 9/1 to 1/9. A crosslinked foam made from the composition and the manufacturing method thereof are also provided.

Abstract: A thermoplastic elastomer composition for crosslinked foam and the manufacturing method thereof are provided. The thermoplastic elastomer composition comprising (A) an ethylene-based copolymer; (B) a first copolymer; (C) a second copolymer, wherein the component (B) and (C) are copolymers comprising a vinyl aromatic monomer and a conjugated diene monomer, the first copolymer having a conjugated diene hydrogenation rate of at least 80% and the second copolymer having a conjugated diene hydrogenation rate of no more than 10%; (D) an organic peroxide; and (E) a foaming agent, wherein a mass ratio (A/(B+C)) of the component (A) to a combination of the component (B) and the component (C) is 95/5 to 5/95; and a mass ratio (B/C) of the component (B) to the component (C) is 9/1 to 1/9. A crosslinked foam made from the composition and the manufacturing method thereof are also provided.

Abstract: This invention provides a novel method for the preparation of 2,3-disubstituted -4-oxy-cyclopentan1-one compounds that are useful for the synthesis of prostaglandins and prostaglandin analogs of industrial relevance. The method comprises the metal-catalyzed asymmetric 1,4-conjugate addition of vinylboron compounds to 2-substituted -4-oxy-cyclopent-2-en-1-ones. This method relies on the use of less toxic, easily-handled reagents, and can be performed under milder conditions than offered by some conventional methods, affording 2,3-disubstituted-4-oxy-cyclopentan-1-one compounds enantio- and diastereoselectively, which are precursors to the said prostaglandin and prostaglandin analogs, in high yield.

Abstract: This invention provides a novel method for the preparation of 2,3-disubstituted-4-oxy-cyclopentan-1-one compounds that are useful for the synthesis of prostaglandins and prostaglandin analogs of industrial relevance. The method comprises the metal-catalyzed asymmetric 1,4-conjugate addition of vinylboron compounds to 2-substituted-4-oxy-cyclopent-2-en-1-ones. This method relies on the use of less toxic, easily-handled reagents, and can be performed under milder conditions than offered by some conventional methods, affording 2,3-disubstituted-4-oxy-cyclopentan-1-one compounds enantio- and diastereoselectively, which are precursors to the said prostaglandin and prostaglandin analogs, in high yield.

Abstract: The present invention provides efficient, economical and environmental friendly methods for synthesis of prostaglandin analogs including tafluprost and intermediates thereof. The invention involves a selective oxidation using in situ boronate ester protection and a unique crystallization method to remove the undesired isomers of fluorinated intermediates.