Abstract: A biosensing system includes a biosensor, a light source, first and second photodetectors, and a calculator. The light source is disposed to irradiate the biosensor, so as to generate two or more of a coupled light beam, a reflected light beam, a transmitted light beam and a diffracted light beam. The first photodetector is disposed to measure an intensity of one of the generated light beams that is indicative of an effect of an analyte on light to obtain a first intensity value. The second photodetector is disposed to measure an intensity of another one of the generated light beams that is indicative of an effect of the analyte on light to obtain a second intensity value. The calculator performs compensation calculation based at least on the first and second intensity values.

Abstract: The present invention provides a dual grating sensor having at least two double-sided grating structures for detecting the properties of an analyte. The dual grating sensor includes a substrate, a waveguide layer which is formed on the substrate and has at least two double-sided grating structures, and an upper cover configured on the waveguide layer, wherein a channel is formed between the upper cover and the waveguide layer for the analyte to flow therethrough. A light couples into the waveguide layer via the first double-sided grating structure, transmits in the waveguide layer, and couples out of the waveguide layer via the second double-sided grating structure, such that the properties of the analyte can be detected according to the change of the light intensities of the emergent light. The sensitivity of the dual grating sensor has an additive effect when the light passes through the first double-sided grating structure and the second double-sided grating structure.

Abstract: A biosensing system includes a biosensor, a light source, first and second photodetectors, and a calculator. The light source is disposed to irradiate the biosensor, so as to generate two or more of a coupled light beam, a reflected light beam, a transmitted light beam and a diffracted light beam. The first photodetector is disposed to measure an intensity of one of the generated light beams that is indicative of an effect of an analyte on light to obtain a first intensity value. The second photodetector is disposed to measure an intensity of another one of the generated light beams that is indicative of an effect of the analyte on light to obtain a second intensity value. The calculator performs compensation calculation based at least on the first and second intensity values.

Abstract: The present invention provides a dual grating sensor having at least two double-sided grating structures for detecting the properties of an analyte. The dual grating sensor includes a substrate, a waveguide layer which is formed on the substrate and has at least two double-sided grating structures, and an upper cover configured on the waveguide layer, wherein a channel is formed between the upper cover and the waveguide layer for the analyte to flow therethrough. A light couples into the waveguide layer via the first double-sided grating structure, transmits in the waveguide layer, and couples out of the waveguide layer via the second double-sided grating structure, such that the properties of the analyte can be detected according to the change of the light intensities of the emergent light. The sensitivity of the dual grating sensor has an additive effect when the light passes through the first double-sided grating structure and the second double-sided grating structure.

Abstract: Disclosed is a microfluidic biosensing system including a processor, in which a Raman barcode database corresponding to at least one Raman spectrum signal is stored, a plurality of Raman barcode beads mixed with a target fluid and coupled to at least one target bioparticle in the target fluid, a microfluidic channel disposed to make the target fluid mixed with the Raman barcode beads flow therethrough, a light source disposed on the microfluidic channel, and a spectral detection device connected to the processor and disposed to correspond to the light source. The spectral detection device receives the Raman spectrum signal generated when the target bioparticle coupled with the Raman barcode bead is irradiated, and transfers the received Raman spectrum signal to the processor. The processor determines a type of the bioparticle(s) and calculates the number of bioparticle(s) by matching the Raman spectrum signal(s) to the Raman barcode database.

Abstract: A method for detecting a preload residual rate involves: a. installing a temperature sensor on one of two preloaded elements; b. making the two preloaded elements to move with respect to each other, and recording a time-related temperature variation sensed by the temperature sensor, so as to obtain an initial temperature-rising curve; c. making the two preloaded elements to move with respect to each other, and recording a time-related temperature variation sensed by the temperature sensor, so as to obtain a detected temperature-rising curve; and d. comparing the initial and detected temperature-rising curves, so as to obtain the preload residual rate between the two preloaded elements of the step c to the step b. The method detects a preload residual rate applied to an object when the object is operating while being advantageous in terms of cost, service life, response and accuracy.

Abstract: Disclosed is a microfluidic biosensing system including a processor, in which a Raman barcode database corresponding to at least one Raman spectrum signal is stored, a plurality of Raman barcode beads mixed with a target fluid and coupled to at least one target bioparticle in the target fluid, a microfluidic channel disposed to make the target fluid mixed with the Raman barcode beads flow therethrough, a light source disposed on the microfluidic channel, and a spectral detection device connected to the processor and disposed to correspond to the light source. The spectral detection device receives the Raman spectrum signal generated when the target bioparticle coupled with the Raman barcode bead is irradiated, and transfers the received Raman spectrum signal to the processor. The processor determines a type of the bioparticle(s) and calculates the number of bioparticle(s) by matching the Raman spectrum signal(s) to the Raman barcode database.

Abstract: A method for detecting a preload residual rate involves: a. installing a temperature sensor on one of two preloaded elements; b. making the two preloaded elements to move with respect to each other, and recording a time-related temperature variation sensed by the temperature sensor, so as to obtain an initial temperature-rising curve; c. making the two preloaded elements to move with respect to each other, and recording a time-related temperature variation sensed by the temperature sensor, so as to obtain a detected temperature-rising curve; and d. comparing the initial and detected temperature-rising curves, so as to obtain the preload residual rate between the two preloaded elements of the step c to the step b. The method detects a preload residual rate applied to an object when the object is operating while being advantageous in terms of cost, service life, response and accuracy.

Abstract: A radiation generating apparatus includes a target base, a target, an electronic beam generating device, a tube, a tank, and a porous structure. The target is disposed on the target base. The electronic beam generating device is adapted to generate an electronic beam, and the electronic beam is emitted to the target to generate a radiation. The tube accommodates the target and the electronic beam generating device. The tank is connected to the target base and accommodates the tube. The porous structure is roundly disposed between the tank and the tube and contacts an inner wall of the tank and an outer wall of the tube. A cooling fluid flows through the porous structure to dissipate the heat of the porous structure.

Abstract: A radiation generating apparatus includes a target base, a target, an electronic beam generating device, a tube, a tank, and a porous structure. The target is disposed on the target base. The electronic beam generating device is adapted to generate an electronic beam, and the electronic beam is emitted to the target to generate a radiation. The tube accommodates the target and the electronic beam generating device. The tank is connected to the target base and is accommodated by the tube. The porous structure is disposed in the tank and contacts the target base. A cooling fluid flows through the porous structure to dissipate the heat of the porous structure.

Abstract: Disclosed is a double-sided grating waveguide biosensor. The double-sided grating waveguide biosensor is used to sense the properties of a sample solution. The double-sided grating waveguide biosensor comprises a sequential stack of a plastic grating having a grating part, a waveguide layer having a double-sided grating structure, and a channel chip. Furthermore, the sample solution is guided into the channel chip; the light beam is coupled into the waveguide layer via the double-sided grating structure, propagates in the waveguide layer, and penetrates outward. The double-sided waveguide biosensor detects the properties of the sample solution via a variation of a light beam intensity of the outgoing light beam.

Abstract: Disclosed is a double-sided grating waveguide biosensor. The double-sided grating waveguide biosensor is used to sense the properties of a sample solution. The double-sided grating waveguide biosensor comprises a sequential stack of a plastic grating having a grating part, a waveguide layer having a double-sided grating structure, and a channel chip. Furthermore, the sample solution is guided into the channel chip; the light beam is coupled into the waveguide layer via the double-sided grating structure, propagates in the waveguide layer, and penetrates outward. The double-sided waveguide biosensor detects the properties of the sample solution via a variation of a light beam intensity of the outgoing light beam.

Abstract: A microfluidic driving system includes a first planar electrode, a second planar electrode, a third planar electrode, a fourth planar electrode, a power supply unit and a detection module. The second, third and fourth planar electrodes are disposed parallel to the first planar electrode and face-to-face with the first planar electrode to form an accommodation space for accommodating a fluid. An AC power is provided by the power supply unit and an AC electrical field is applied by alternately connecting the third planar electrode and the fourth planar electrode with the first planar electrode for driving the first fluid and the second fluid to flow; and then AC electrical field is also applied by connecting the second planar electrode to the first planar electrode to mix the first fluid and the second fluid. Finally, a detection is performed upon a mixture of the fluids through the detection module.

Abstract: A microfluidic device with microstructure includes a channel for accommodating an electrolytic solution therein and at least one microstructure formed in the channel. When an alternating-current signal is input to the microfluidic device so that a surface of the microstructure is polarized by a generated electric field, ions having polarity reverse to that of an electrolytic solution will migrate to the surface of the microstructure to form a field-induced electrical double layer to result in electro-osmotic flows at the corners at two sides of the microstructure, which causes formation of relatively fierce circular vortices in the solution. A sensing system and a sensing method using the microfluidic device with microstructure are also disclosed.

Abstract: A sensing system comprises a light source, an optical fiber, a plurality of noble metal nano-particles, a micro-fluidic module and a photo detector. The optical fiber couples an incident light. The plurality of noble metal nano-particles are disposed on a surface of the optical fiber to form a noble metal nano-particle submonolayer, the noble metal nano-particles are substantially separated from each adjacent noble metal nano-particles such that the conductivity of the noble metal nano-particle submonolayer is smaller than that of a metal film. The micro-fluidic module accommodates the optical fiber and a sample, and the sample is driven to contact with the noble metal nano-particles. The photo detector detects an emergent light from the optical fiber. When the incident light interacts with the noble metal nano-particles, a signal derived from localized surface plasmon resonance in form of attenuated light or elastic scattered light is outputted through the photo detector.

Abstract: A bio-sensing system comprises a light source, a bio-sensing apparatus, a detecting platform, and a processing unit. A bio-sensing apparatus further comprising a substrate, a sample with at least one analyte, at least one grating bound on the substrate for diffracting a light beam in a reflection mode and outputting at least one output light beam, a plurality of nanoparticles being bound on one side of the grating, a molecular recognition unit bound on said nanoparticle surface, and a cover plate covering the nanoparticle-modified side of the substrate. The detecting platform receives a signal while the at least one output light beam passing through the bio-sensing apparatus. The processing unit couples with the detecting platform for receiving and analyzing the signal.

Abstract: A microfluidic driving system includes a first planar electrode, a second planar electrode, a third planar electrode, a fourth planar electrode, a power supply unit and a detection module. The second, third and fourth planar electrodes are disposed parallel to the first planar electrode and face-to-face with the first planar electrode to form an accommodation space for accommodating a fluid. An AC power is provided by the power supply unit and an AC electrical field is applied by alternately connecting the third planar electrode and the fourth planar electrode with the first planar electrode for driving the first fluid and the second fluid to flow; and then AC electrical field is also applied by connecting the second planar electrode to the first planar electrode to mix the first fluid and the second fluid. Finally, a detection is performed upon a mixture of the fluids through the detection module.

Abstract: A sensing system comprises a light source, an optical fiber, a plurality of noble metal nano-particles, a micro-fluidic module and a photo detector. The optical fiber couples an incident light. The plurality of noble metal nano-particles are disposed on a surface of the optical fiber to form a noble metal nano-particle submonolayer, the noble metal nano-particles are substantially separated from each adjacent noble metal nano-particles such that the conductivity of the noble metal nano-particle submonolayer is smaller than that of a metal film. The micro-fluidic module accommodates the optical fiber and a sample, and the sample is driven to contact with the noble metal nano-particles. The photo detector detects an emergent light from the optical fiber. When the incident light interacts with the noble metal nano-particles, a signal derived from localized surface plasmon resonance in form of attenuated light or elastic scattered light is outputted through the photo detector.

Abstract: A method and an apparatus for detection of a bioparticle by single-bead based DEP. The method includes the steps of immobilizing a single DEP bead in one electric field; immobilizing a first bio-recognizing molecule on the single DEP bead; intromitting at least one target bioparticle into the electric field for binding the first bio-recognizing molecule, whereby the target bioparticle and the first bio-recognizing molecule are bound with each other to form a complex molecule; and detecting the complex molecule by a detection device. The apparatus is composed of a chip, a power source, a single DEP bead, and a detection device.

Abstract: A microfluidic device with microstructure includes a channel for accommodating an electrolytic solution therein and at least one microstructure formed in the channel. When an alternating-current signal is input to the microfluidic device so that a surface of the microstructure is polarized by a generated electric field, ions having polarity reverse to that of an electrolytic solution will migrate to the surface of the microstructure to form a field-induced electrical double layer to result in electro-osmotic flows at the corners at two sides of the microstructure, which causes formation of relatively fierce circular vortices in the solution. A sensing system and a sensing method using the microfluidic device with microstructure are also disclosed.