Patents by Inventor Wen-Hsiung Li

Wen-Hsiung Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250121543
    Abstract: An injection molding apparatus includes a first mold module, a second mold module, and an ejection mechanism. The second mold module is disposed on the first mold module. An injection chamber and a product chamber are formed between the first mold module and the second mold module. The ejection mechanism includes a main ejection assembly; a main ejection rod mounted to the main ejection assembly and passes through the first mold module; the central ejection assembly disposed in the main ejection assembly; and a central ejection rod mounted to the central ejection assembly and passes through the first mold module. After plastic in the injection chamber and the product chamber are cooled, a plastic product and an injection part connected to the plastic product are formed. Next, the central ejection assembly is lifted to separate the injection part from the plastic product by the central ejection rod.
    Type: Application
    Filed: October 31, 2023
    Publication date: April 17, 2025
    Applicant: Shenzhen Fulian Fugui Precision Industry Co., Ltd.
    Inventors: WEN-HSIUNG WU, XIAO-HONG FAN, ZHENG-LI LI
  • Publication number: 20250107117
    Abstract: A Schottky diode includes a substrate with an epitaxy layer on which a cathode region and an anode region are defined. A cathode structure and an anode structure are formed in the cathode region and the anode region respectively and horizontally separated by a distance. The anode structure includes a plurality of p-type doped regions diffused from the epitaxy layer toward the substrate, with an interval is formed between adjacent two p-type doped regions. A backside metal film and a backside protection layer are sequentially formed on a back surface of the substrate. Since the manufacturing of the Schottky diode does not involve wire bonding and molding processes, the overall thickness of the Schottky diode is reduced and heat dissipation is improved. With the backside metal film on the back side of the substrate, an equivalent resistance and a forward voltage of the Schottky diode can be reduced.
    Type: Application
    Filed: November 15, 2023
    Publication date: March 27, 2025
    Inventors: CHUNG-HSIUNG HO, CHI-HSUEH LI, CHIA-WEI CHEN, YU-MING HSU, WEN-LIANG HUANG, MING-KUN HSIN, SHIH-MING CHEN
  • Publication number: 20250057876
    Abstract: Disclosed herein is a method for treating and/or preventing a lymphangiogenesis-associated disease in a subject, including administering to the subject a therapeutically effective amount of a dihydrolipoic acid (DHLA)-coated gold nanocluster about 0.1 to 10 nm in diameter. Also disclosed is a method for promoting lymphangiogenesis in a subject, including administering to the subject an effective amount of said DHLA-coated gold nanocluster.
    Type: Application
    Filed: August 18, 2023
    Publication date: February 20, 2025
    Inventors: Hung-I YEH, Yih-Jer WU, Shih-Wei WANG, Ching-Hu CHUNG, Cheng-Yung LIN, Wen-Hsiung CHAN, Kuan-Jung LI, Hong-Shong CHANG
  • Patent number: 12221613
    Abstract: A transgenic rice plant containing in its genome a recombinant DNA construct that includes a first nucleic acid having a sequence of a first Golden 2-like transcription factor (GLK) gene operably linked to its natural promoter and 5? untranslated region (5?UTR), and a second nucleic acid having a sequence of a second GLK gene operably linked to its natural promoter and 5?UTR, the second GLK gene being distinct from the first GLK gene. The first GLK gene and the second GLK gene are both from a C4 plant and the transgenic rice plant exhibits a 65-106% increase in shoot biomass and a 50-95% increase in grain yield, as compared to an untransformed wild-type rice plant. Also provided is a method for producing the transgenic rice plant and a recombinant DNA construct that can be used in the method.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: February 11, 2025
    Assignee: Academia Sinica
    Inventors: Su-Ying Yeh, Hsin-Hung Lin, Maurice S. B. Ku, Wen-Hsiung Li
  • Patent number: 11858965
    Abstract: The present disclosure relates to a recombinant protein comprising a plurality of type II cohesin repeats. The present disclosure provides a recombinant cellulosome complex comprising: the recombinant protein comprising a plurality of type II cohesin repeats; a recombinant cellulosome complex integrating protein A comprising a plurality of type I cohesin repeats, a plurality of cellulose-binding modules and a type II dockerin; and a plurality of recombinant enzymes each comprising a type I dockerin. A cell, a method for digesting a cellulose and a method for producing ethanol are also provided.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: January 2, 2024
    Assignee: ACADEMIA SINICA
    Inventors: Wen-Hsiung Li, Anandharaj Marimuthu, Jui-Jen Chang, Yu-Ju Lin, Rizwana Parveen Rani Mohamed Gobil, Chieh-Chen Huang
  • Patent number: 11781124
    Abstract: Disclosed herein are recombinant polynucleotide sequences, vectors, host cells and methods for producing astaxanthin. The recombinant polynucleotide sequence is designed to provide a higher level of astaxanthin precursors via a shorter metabolic pathway, and thereby attains higher level of end products (e.g., astaxanthin) with desired stereoisomeric form and/or esterified form.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: October 10, 2023
    Assignee: ACADEMIA SINICA
    Inventors: Jui-Jen Chang, Caroline Thia, Hao-Yeh Lin, Yu-Ju Lin, Chieh-Chen Huang, Wen-Hsiung Li
  • Publication number: 20230203521
    Abstract: A transgenic rice plant containing in its genome a recombinant DNA construct that includes a first nucleic acid having a sequence of a first Golden 2-like transcription factor (GLK) gene operably linked to its natural promoter and 5? untranslated region (5?UTR), and a second nucleic acid having a sequence of a second GLK gene operably linked to its natural promoter and 5?UTR, the second GLK gene being distinct from the first GLK gene. The first GLK gene and the second GLK gene are both from a C4 plant and the transgenic rice plant exhibits a 65-106% increase in shoot biomass and a 50-95% increase in grain yield, as compared to an untransformed wild-type rice plant. Also provided is a method for producing the transgenic rice plant and a recombinant DNA construct that can be used in the method.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 29, 2023
    Inventors: Su-Ying Yeh, Hsin-Hung Lin, Maurice S. B. Ku, Wen-Hsiung Li
  • Publication number: 20210363196
    Abstract: The present disclosure relates to a recombinant protein comprising a plurality of type II cohesin repeats. The present disclosure provides a recombinant cellulosome complex comprising: the recombinant protein comprising a plurality of type II cohesin repeats; a recombinant cellulosome complex integrating protein A comprising a plurality of type I cohesin repeats, a plurality of cellulose-binding modules and a type II dockerin; and a plurality of recombinant enzymes each comprising a type I dockerin. A cell, a method for digesting a cellulose and a method for producing ethanol are also provided.
    Type: Application
    Filed: May 21, 2021
    Publication date: November 25, 2021
    Inventors: Wen-Hsiung LI, Anandharaj MARIMUTHU, Jui-Jen CHANG, Yu-Ju LIN, Rizwana Parveen Rani MOHAMED GOBIL, Chieh-Chen HUANG
  • Publication number: 20210071153
    Abstract: Disclosed herein are recombinant polynucleotide sequences, vectors, host cells and methods for producing astaxanthin. The recombinant polynucleotide sequence is designed to provide a higher level of astaxanthin precursors via a shorter metabolic pathway, and thereby attains higher level of end products (e.g., astaxanthin) with desired stereoisomeric form and/or esterified form.
    Type: Application
    Filed: November 10, 2020
    Publication date: March 11, 2021
    Inventors: Jui-Jen CHANG, CAROLINE THIA, HAO-YEH LIN, YU-JU LIN, CHIEH-CHEN HUANG, WEN-HSIUNG LI
  • Patent number: 10865397
    Abstract: Disclosed herein are recombinant polynucleotide sequences, vectors, host cells and methods for producing astaxanthin. The recombinant polynucleotide sequence is designed to provide a higher level of astaxanthin precursors via a shorter metabolic pathway, and thereby attains higher level of end products (e.g., astaxanthin) with desired stereoisomeric form and/or esterified form.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: December 15, 2020
    Assignee: ACADEMIA SINICA
    Inventors: Jui-Jen Chang, Caroline Thia, Hao-Yeh Lin, Yu-Ju Lin, Chieh-Chen Huang, Wen-Hsiung Li
  • Publication number: 20190144841
    Abstract: Disclosed herein are recombinant polynucleotide sequences, vectors, host cells and methods for producing astaxanthin. The recombinant polynucleotide sequence is designed to provide a higher level of astaxanthin precursors via a shorter metabolic pathway, and thereby attains higher level of end products (e.g., astaxanthin) with desired stereoisomeric form and/or esterified form.
    Type: Application
    Filed: November 26, 2018
    Publication date: May 16, 2019
    Inventors: Jui-Jen CHANG, Caroline THIA, Hao-Yeh LIN, Yu-Ju LIN, Chieh-Chen HUANG, Wen-Hsiung LI
  • Patent number: 10087450
    Abstract: Described herein is an engineered Kluyveromyces marxianus cell, the cell comprising in its genome: (i) two different nucleic acid molecules that each contain a promoter operably linked to a gene encoding a functional enzyme, and (ii) a selection nucleic acid molecule that contains a promoter operably linked to a gene encoding a selectable marker, wherein all of the nucleic acids molecules of (i) and (ii) are in tandem and the engineered cell expresses all of the proteins encoded by the genes of (i) and (ii).
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: October 2, 2018
    Assignee: Academia Sinica
    Inventors: Jui-Jen Chang, Wen-Hsiung Li, Chieh-Chen Huang, Hao-Yeh Lin, Ming-Che Shih
  • Publication number: 20170137792
    Abstract: Disclosed herein are recombinant polynucleotide sequences, vectors, host cells and methods for producing astaxanthin. The recombinant polynucleotide sequence is designed to provide a higher level of astaxanthin precursors via a shorter metabolic pathway, and thereby attains higher level of end products (e.g., astaxanthin) with desired stereoisomeric form and/or esterified form.
    Type: Application
    Filed: November 16, 2016
    Publication date: May 18, 2017
    Inventors: Jui-Jen CHANG, Caroline THIA, Hao-Yeh LIN, Yu-Ju LIN, Chieh-Chen HUANG, Wen-Hsiung LI
  • Publication number: 20160251663
    Abstract: Described herein is an engineered Kluyveromyces marxianus cell, the cell comprising in its genome: (i) two different nucleic acid molecules that each contain a promoter operably linked to a gene encoding a functional enzyme, and (ii) a selection nucleic acid molecule that contains a promoter operably linked to a gene encoding a selectable marker, wherein all of the nucleic acids molecules of (i) and (ii) are in tandem and the engineered cell expresses all of the proteins encoded by the genes of (i) and (ii).
    Type: Application
    Filed: May 17, 2016
    Publication date: September 1, 2016
    Inventors: Jui-Jen Chang, Wen-Hsiung Li, Chieh-Chen Huang, Hao-Yeh Lin, Ming-Che Shih
  • Patent number: 9340794
    Abstract: Described is a method of introducing multiple nucleic acid molecules into the genome of a cell. The method includes providing a plurality of nucleic acid molecules, each of the plurality of nucleic acid molecules containing (a) a nucleic acid sequence operatively linked to a promoter sequence at the 5? end of the nucleic acid molecule, and (b) an overlapping sequence at the 3? end of the nucleic acid molecule.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: May 17, 2016
    Assignee: Academia Sinica
    Inventors: Jui-Jen Chang, Feng-Ju Ho, Cheng-Yu Ho, Wen-Hsiung Li, Ming-Che Shih, Chieh-Chen Huang
  • Publication number: 20140248703
    Abstract: Described is a method of introducing multiple nucleic acid molecules into the genome of a cell. The method includes providing a plurality of nucleic acid molecules, each of the plurality of nucleic acid molecules containing (a) a nucleic acid sequence operatively linked to a promoter sequence at the 5? end of the nucleic acid molecule, and (b) an overlapping sequence at the 3? end of the nucleic acid molecule.
    Type: Application
    Filed: August 31, 2012
    Publication date: September 4, 2014
    Applicant: Academia Sinica
    Inventors: Jui-Jen Chang, Feng-Ju Ho, Cheng-Yu Ho, Wen-Hsiung Li, Ming-Che Shih, Chieh-Chen Huang
  • Patent number: 8791156
    Abstract: A polyacetylenes and application thereof. The polyacetylenes is isolated from an extract of the sporophores of Antrodia Cinnamomea and has a function of inhibiting the production of nitric oxide. Therefore, the polyacetylenes can be used for preparing a pharmaceutical composition for anti-inflammation. The present invention also teaches the representative metabolites of the sporophores of Antrodia Cinnamomea, which can be used to evaluate the quality thereof.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: July 29, 2014
    Inventors: Sheng-Yang Wang, Ting-Yu Lin, Chieh-Yin Chen, Shih-Chang Chien, Wen-Wei Hsiao, Fang-Hua Chu, Wen-Hsiung Li, Jei-Fu Shaw, Chin-Chung Lin
  • Patent number: 8703474
    Abstract: Disclosed are a novel flavor compound-producing yeast strain and methods of using the strain to produce flavor compounds.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: April 22, 2014
    Assignee: Academia Sinica
    Inventors: Jui-Jen Chang, Cheng-Yu Ho, Chieh-Chen Huang, Ming-Che Shih, Wen-Hsiung Li
  • Patent number: 8431371
    Abstract: An expression system for producing a multi-enzyme complex, the system including a nucleic acid molecule containing a promoter operatively linked to a nucleotide sequence including multiple genes encoding multiple enzymes that are components of the multi-enzyme complex.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: April 30, 2013
    Assignee: Academia Sinica
    Inventors: Wen-Hsiung Li, Ming-Che Shih, Chieh-Chen Huang, Jui-Jen Chang, Cheng-Yu Ho
  • Patent number: 8354266
    Abstract: A polycistronic expression cassette encoding proteins necessary for constructing a multi-enzyme complex was developed. Also disclosed herein is a host cell containing this polycistronic expression cassette and uses thereof in degrading biomass.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: January 15, 2013
    Assignee: Academia Sinica
    Inventors: Wen-Hsiung Li, Ming-Che Shih, Chieh-Chen Huang, Jui-Jen Chang, Cheng-Yu Ho