Abstract: A method includes forming a dummy gate over a semiconductor fin; forming a source/drain epitaxial structure over the semiconductor fin and adjacent to the dummy gate; depositing an interlayer dielectric (ILD) layer to cover the source/drain epitaxial structure; replacing the dummy gate with a gate structure; forming a dielectric structure to cut the gate structure, wherein a portion of the dielectric structure is embedded in the ILD layer; recessing the portion of the dielectric structure embedded in the ILD layer; after recessing the portion of the dielectric structure, removing a portion of the ILD layer over the source/drain epitaxial structure; and forming a source/drain contact in the ILD layer and in contact with the portion of the dielectric structure.

Abstract: The present invention relates to UNC13A cryptic exon antisense oligonucleotides (ASOs), pharmaceutical compositions containing them, and methods for treating, inhibiting, suppressing, and preventing neurological diseases with them.

Abstract: The present invention relates to PIKFYVE antisense oligonucleotides (ASOs), pharmaceutical compositions containing them, and methods for treating, inhibiting, suppressing, and preventing neurological diseases with them.

Abstract: The present invention relates to systems and methods for reprogramming cells to generate neurons and identifying effective treatments for neurodegenerative disorders using such neurons, as well as systems and methods for treating and developing treatments for one or more neurodegenerative disorders.

Abstract: A stable aqueous dispersion having a particle size in the range of about 10 to 200 nanometers containing specific silanes carrying at least one hydrophobic moiety and at least one water-solubilizing moiety is used in a process for treating a cellulosic substrate resulting in a treated product. The aqueous dispersions used in treating the cellulosic substrate are stable for at least 20 days without externally added surfactant.

Abstract: New organic silanes are claimed carrying at least one water-solubilizing moiety and at least one hydrophobic group suitable for preparing stable solutions or dispersions containing in excess of about five weight percent of such silanes.

Abstract: A stable aqueous dispersion having a particle size in the range of about 10 to about 200 nanometers containing specific silanes carrying at least one hydrophobic moiety and at least one water-solubilizing moiety is claimed along with the process for treating a cellulosic substrate and the treated cellulosic product resulting therefrom. The aqueous dispersions are stable for at least 20 days without externally added surfactant.

Abstract: Disclosed is an aqueous composition containing a vinyl-type polymer product having hydrolyzable silyl groups which aqueous composition is stable at relatively high solids for such a composition and yet cures at relatively low temperatures upon the evaporation of water. More particularly, disclosed is a stable, aqueous, colloidal silica-free, dispersion or solution containing a solution-polymerized vinyl-type polymer having acid functionality sufficient to provide an acid value of from 5 to 160 and having a hydroxyl value of less than or equal to 10 and sufficient hydrolyzable silyl groups to provide a Si content in the range of from 0.40 to 6.0 percent by weight based on the total weight of the vinyl-type polymer. The vinyl-type polymer is characterized in that a composition consisting of at least 25 percent by weight of the polymer in water remains stable in a closed container for at least 24 hours at a temperature of 48.9 degrees Celsius.

Abstract: Disclosed herein are amido-amine silane resins prepared by reacting an aminosilane with a hydroxy alkyl functional amine and a polyisocyanate or a polyacid or its lower alkyl ester.

Abstract: An aqueous polymer emulsion latex is claimed composed of particles comprising a vinyl polymer and a surfactant containing at least one hydrophobic moiety and at least one hydrophilic moiety and also carrying silicon moieties and amido functionalities. Also claimed are coating compositions containing the aqueous polymer emulsion latex, processes for preparing the aqueous polymer emulsion latex wherein ethylenically unsaturated monomers are polymerized in the presence of a surfactant containing a silicon moiety and amido functionality, and substrates carrying a coating composition containing the aqueous polymer emulsion latex.

Abstract: Disclosed herein are organosilane resins which are derived from an aminoalkoxysilane and hydroxy- and amine-functional compound; said resins are useful in curable compositions containing epoxy materials.

Abstract: An abrasion and solvent resistant polyurethane protective coating for bilayer windshields is formulated by the reaction of a polyester or polyether diol with an aliphatic isocyanate-terminated prepolymer.

Abstract: An abrasion and solvent resistant polyurethane protective coating for bilayer windshields is formulated by the reaction of a polyester or polyether diol with an aliphatic isocyanate-terminated prepolymer.

Abstract: Disclosed are essentially zinc-free, organic coating compositions based on silicon-containing polyols comprising reaction products of hydrophobic polyols, organosilicon-containing materials, and higher monohydric alcohols, R-OH. The organosilicon-containing material comprises an organosilicon-containing substance free of certain functional groups attached directly to carbon and essentially free of alkali metal ions. The organosilicon-containing substance has atoms bonded directly to Si all of which are selected from O, N, and/or Cl. The organosilicon-containing substance also has moieties directly bonded to Si which are displaceable by reaction with water and/or alcohol. The reaction product is not capable of being gelled when subjected to a specific gel test, has a content of hydroxyl groups from the hydrophobic polyol ranging from 0.4 to 10 milliequivalents per gram of reaction product, has a content of groups, --OR, from the higher monofunctional alcohol ranging from 0.

Abstract: A composition of matter contains as a principal component a material which acts as an ultraviolet light stabilizer. The ultraviolet light stabilizer is formed from the reaction of (a) a methylol or alkoxy alkyl-containing material, and (b) an alkyl substituted piperidine containing material which is represented by the following structural formula: ##STR1## R" is hydrogen or C.sub.1 to C.sub.6 alkyl, R.sub.10 is hydrogen or methyl,Y is a radical derived from a material selected from the group consisting of amino substituted triazines, ureas, glycolurils, phenols, and amides of the formula ##STR2## R' is hydrogen or C.sub.1 to C.sub.12 alkyl and R is an aliphatic, cycloaliphatic, or olefinic radical, or an acrylic polymer moiety having at least one group selected from hydroxyl, carboxyl, amido, and ureido, said reaction proceeding between a methylol or alkoxy alkyl group of (a) and the group selected from hydroxyl, carboxyl, amido and ureido of (b).

Abstract: Disclosed are moisture-curable compositions based on (A) ungelled, partial hydrolyzates or organosilicon-containing materials in combination with (B) acrylic addition interpolymers containing hydrolyzable silyl groups.The organosilicon-containing material for preparation of the ungelled partial hydrolysis product has an average functionality based on easily hydrolyzable Y groups attached to silicon atoms of greater than or equal to 2.4 and contains greater than or equal to 10 mole percent of at least one organosilane compound corresponding to the formula R-Si-Y.sub.3. The partial hydrolysis product is prepared using a controlled amount of water.The acrylic addition interpolymer is not particularly limited provided that it contains at least one silicon atom directly bonded to a hydrolyzable group and is compatible with the ungelled partial hydrolysis product.

Abstract: A coating composition contains at least 15 percent by weight of an ungelled reaction product of:(i) at least 2 percent by weight of an amine having in a molecule thereof at least one amino hydrogen atom, and at least one silicon atom directly bonded to a hydrolyzable group;(ii) at least 4 percent by weight of a material containing at least one epoxide group, at least 30 percent of said material being essentially free of hydroxyl groups; and(iii) a material selected from vinyl alkoxysilanes; nonfunctional organosilanes; organosilicates; and partial hydrolysis products thereof; the percentages by weight being based on the total weight of the resin solids of the coating composition including (i), (ii) and (iii).

Abstract: A polymeric reaction product, a process for its preparation and a coating composition containing the reaction product as a binder are described. The polymeric reaction product is prepared by the vinyl addition polymerization of a vinyl monomer component of which at least 50 percent by weight is an active hydrogen-containing vinyl monomer in the presence of a polymeric diluent. The rate of polymerization is controlled such that the amount of unreacted vinyl monomer, on the average, does not exceed 10 percent by weight of the total weight of the reaction mixture.

Abstract: Disclosed is an ungelled resin comprising a compound corresponding to a specified formula (I) which compound typically is prepared by reaction of an aminoalkyloxy silane with an organic isocyanate. The ungelled resin contains a hydrolyzable group that is attached directly to Silicon. The ungelled resin can be utilized in coating compositions. The ungelled resin can be cured with moisture and/or with polyols, and can be used to provide protective and/or decorative films on a variety of substrates.The novel compounds contained in the ungelled resin for convenience can be thought of as prepared from an organic isocyanate having an average functionality of at least 1; a silicon-containing compound corresponding to a specified formula (III) infra, the silicon-containing compound having at least one hydrolyzable group; and a compound containing at least 2 carbon atoms, at least 1 functional group reactive with a moiety on the silicon-containing compound and at least one amino group.

Abstract: Disclosed is an ungelled resin composition comprising a compound having at least one group containing a silicon atom selected from: ##STR1## wherein Q represents the residue from an organic polyol selected from the group consisting of (1) simple diols, triols and higher hydric alcohols, (2) polyester polyols, (3) polyether polyols, (4) amide-containing polyols, (5) epoxy polyols and (6) polyhydric polyvinyl alcohols, and eachR independently is selected from the group of moieties consisting of hydrogen, and a C.sub.1 -C.sub.10 group joined to Si through an Si-C linkage, andY represents an easily hydrolyzable group.The ungelled resin composition contains an amount of easily hydrolyzable Y moieties directly bonded to silicon atoms such that the ratio of the number of grams of the ungelled resin composition to equivalents of easily hydrolyzable Y moieties in the ungelled resin composition is in a range of from 40 to 667.