Abstract: The present invention relates to PIKFYVE antisense oligonucleotides (ASOs), pharmaceutical compositions containing them, and methods for treating, inhibiting, suppressing, and preventing neurological diseases with them.

Abstract: The present invention relates, in part, to methods, compounds, and compositions of an autophagy pathway inhibitor in combination with a dual RAF/MEK inhibitor, for treating abnormal cell growth (e.g., cancer).

Abstract: A method for customizing an appearance of a merchandise which is suitable for being performed by a computing device in order to customize a customized choice result selected by a user includes a designed image and a merchandise information. The method includes receiving the designed image, receiving the merchandise information, overlappingly displaying the designed image on a virtual merchandise image corresponding to the merchandise information, receiving at least one edit operation for at least one designed element in the designed image, and editing for the designed element in the designed image according to the edit operation and then generating a customizing virtual image. Thereby, the method can be used for customizing an appearance of a merchandise and directly customize the designed image that has been arranged. In addition, a computing device and a non-transitory computer-readable recording medium for customizing the appearance of the merchandise are also provided.

Abstract: An electronic device and a manufacturing method thereof are provided in the present disclosure. The electronic device includes a circuit structure, a plurality of electronic components and a structural unit. The circuit structure includes a plurality of conductive layers and at least one insulating layer. The plurality of conductive layers are electrically interconnected via a plurality of through holes in the at least one insulating layer. The plurality of electronic components are electrically connected to the circuit structure and are overlapped with the circuit structure. The structural unit is disposed adjacent to the plurality of electronic components. In a top view of the electronic device, at least a portion of the structural unit is disposed between adjacent two of the electronic components.

Abstract: The present invention relates to UNC13A cryptic exon antisense oligonucleotides (ASOs), pharmaceutical compositions containing them, and methods for treating, inhibiting, suppressing, and preventing neurological diseases with them.

Abstract: The present invention relates to PIKFYVE antisense oligonucleotides (ASOs), pharmaceutical compositions containing them, and methods for treating, inhibiting, suppressing, and preventing neurological diseases with them.

Abstract: The present invention relates to UNC13A cryptic exon antisense oligonucleotides (ASOs), pharmaceutical compositions containing them, and methods for treating, inhibiting, suppressing, and preventing neurological diseases with them.

Abstract: The present invention relates to UNC13A cryptic exon antisense oligonucleotides (ASOs), pharmaceutical compositions containing them, and methods for treating, inhibiting, suppressing, and preventing neurological diseases with them.

Abstract: The present invention relates to PIKFYVE antisense oligonucleotides (ASOs), pharmaceutical compositions containing them, and methods for treating, inhibiting, suppressing, and preventing neurological diseases with them.

Abstract: The present invention relates to systems and methods for reprogramming cells to generate neurons and identifying effective treatments for neurodegenerative disorders using such neurons, as well as systems and methods for treating and developing treatments for one or more neurodegenerative disorders.

Abstract: A stable aqueous dispersion having a particle size in the range of about 10 to 200 nanometers containing specific silanes carrying at least one hydrophobic moiety and at least one water-solubilizing moiety is used in a process for treating a cellulosic substrate resulting in a treated product. The aqueous dispersions used in treating the cellulosic substrate are stable for at least 20 days without externally added surfactant.

Abstract: New organic silanes are claimed carrying at least one water-solubilizing moiety and at least one hydrophobic group suitable for preparing stable solutions or dispersions containing in excess of about five weight percent of such silanes.

Abstract: A stable aqueous dispersion having a particle size in the range of about 10 to about 200 nanometers containing specific silanes carrying at least one hydrophobic moiety and at least one water-solubilizing moiety is claimed along with the process for treating a cellulosic substrate and the treated cellulosic product resulting therefrom. The aqueous dispersions are stable for at least 20 days without externally added surfactant.

Abstract: Disclosed is an aqueous composition containing a vinyl-type polymer product having hydrolyzable silyl groups which aqueous composition is stable at relatively high solids for such a composition and yet cures at relatively low temperatures upon the evaporation of water. More particularly, disclosed is a stable, aqueous, colloidal silica-free, dispersion or solution containing a solution-polymerized vinyl-type polymer having acid functionality sufficient to provide an acid value of from 5 to 160 and having a hydroxyl value of less than or equal to 10 and sufficient hydrolyzable silyl groups to provide a Si content in the range of from 0.40 to 6.0 percent by weight based on the total weight of the vinyl-type polymer. The vinyl-type polymer is characterized in that a composition consisting of at least 25 percent by weight of the polymer in water remains stable in a closed container for at least 24 hours at a temperature of 48.9 degrees Celsius.

Abstract: Disclosed herein are amido-amine silane resins prepared by reacting an aminosilane with a hydroxy alkyl functional amine and a polyisocyanate or a polyacid or its lower alkyl ester.

Abstract: An aqueous polymer emulsion latex is claimed composed of particles comprising a vinyl polymer and a surfactant containing at least one hydrophobic moiety and at least one hydrophilic moiety and also carrying silicon moieties and amido functionalities. Also claimed are coating compositions containing the aqueous polymer emulsion latex, processes for preparing the aqueous polymer emulsion latex wherein ethylenically unsaturated monomers are polymerized in the presence of a surfactant containing a silicon moiety and amido functionality, and substrates carrying a coating composition containing the aqueous polymer emulsion latex.

Abstract: Disclosed herein are organosilane resins which are derived from an aminoalkoxysilane and hydroxy- and amine-functional compound; said resins are useful in curable compositions containing epoxy materials.

Abstract: An abrasion and solvent resistant polyurethane protective coating for bilayer windshields is formulated by the reaction of a polyester or polyether diol with an aliphatic isocyanate-terminated prepolymer.

Abstract: An abrasion and solvent resistant polyurethane protective coating for bilayer windshields is formulated by the reaction of a polyester or polyether diol with an aliphatic isocyanate-terminated prepolymer.

Abstract: Disclosed are essentially zinc-free, organic coating compositions based on silicon-containing polyols comprising reaction products of hydrophobic polyols, organosilicon-containing materials, and higher monohydric alcohols, R-OH. The organosilicon-containing material comprises an organosilicon-containing substance free of certain functional groups attached directly to carbon and essentially free of alkali metal ions. The organosilicon-containing substance has atoms bonded directly to Si all of which are selected from O, N, and/or Cl. The organosilicon-containing substance also has moieties directly bonded to Si which are displaceable by reaction with water and/or alcohol. The reaction product is not capable of being gelled when subjected to a specific gel test, has a content of hydroxyl groups from the hydrophobic polyol ranging from 0.4 to 10 milliequivalents per gram of reaction product, has a content of groups, --OR, from the higher monofunctional alcohol ranging from 0.