Patents by Inventor Wen-Hsun Kuo

Wen-Hsun Kuo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8513405
    Abstract: Disclosed are a chaotropic agent; a reagent including a chaotropic agent and a lithium salt; a reagent kit including a chaotropic agent; a chaotropic agent, a reagent, a reagent kit, and a method for isolating a nucleic acid by use of a magnetic cellulose material; a method for binding a nucleic acid to a magnetic cellulose material; a method for isolating a nucleic acid; and a method for purifying a chromosome DNA. It is required that each of the chaotropic agents, the reagents, and the reagent kits works with at least one solid-phase, magnetic cellulose-containing carrier to isolate a nucleic acid from non-nucleic acid substances. In addition, each chaotropic agent includes an alcohol substance and a substrate solution for adjusting the alcohol substance to an appropriate concentration and thereby promoting binding of the nucleic acid in a sample to the magnetic cellulose.
    Type: Grant
    Filed: April 2, 2008
    Date of Patent: August 20, 2013
    Assignee: RBC Bioscience Corp.
    Inventors: Pei-Shin Jiang, Yu-Ting Su, Kun-Chan Wu, Hui-Ju Cho, Wen-Hsun Kuo, Yuh-Jiuan Lin, Yi-Ling Li, Cheng-Chun Kuan
  • Publication number: 20110166338
    Abstract: Disclosed are a chaotropic agent; a reagent including a chaotropic agent and a lithium salt; a reagent kit including a chaotropic agent; a chaotropic agent, a reagent, a reagent kit, and a method for isolating a nucleic acid by use of a magnetic cellulose material; a method for binding a nucleic acid to a magnetic cellulose material; a method for isolating a nucleic acid; and a method for purifying a chromosome DNA. It is required that each of the chaotropic agents, the reagents, and the reagent kits works with at least one solid-phase, magnetic cellulose-containing carrier to isolate a nucleic acid from non-nucleic acid substances. In addition, each chaotropic agent includes an alcohol substance and a substrate solution for adjusting the alcohol substance to an appropriate concentration and thereby promoting binding of the nucleic acid in a sample to the magnetic cellulose.
    Type: Application
    Filed: April 2, 2008
    Publication date: July 7, 2011
    Inventors: Pei-Shin Jiang, Yu-Ting Su, Kun-Chan Wu, Hui-Ju Cho, Wen-Hsun Kuo, Yuh-Jiuan Lin, Yi-Ling Li, Cheng-Chun Kuan
  • Patent number: 7868145
    Abstract: A magnetic particle and fabrication method thereof. The magnetic particle comprises a polymer core, a magnetic material layer covering the polymer core, and a silicon containing layer covering the magnetic material layer. In addition, the magnetic particle may further comprise a coupling agent on the silicon containing layer, and an active molecule connected to the coupling agent. The magnetic particles provide controllable size, uniform diameter distribution, high magnetization, improved storage stability, and modified surface for targeting biomolecules for biomaterial separation and environmental analysis.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: January 11, 2011
    Assignee: Industrial Technology Research Institute
    Inventors: Kun Chan Wu, Hui-Ju Cho, Pei-Shin Jiang, Hsiang Yuan Huang, Wen-Hsun Kuo, Chi-Min Chau, Chih Hsien Su, Kun Feng Lee
  • Patent number: 7740759
    Abstract: A magnetic separation device separating magnetic material from a working fluid of a container is disclosed. The magnetic separation device includes a first element, a second element and a magnetic assembly structure including a plurality of magnetic units. The first element includes a first body, a plurality of first main positioning portions disposed on the first body, and a plurality of first sub-positioning portions disposed on the first body and next to the first main positioning portions to receive the container. The second element includes a second body, a plurality of second main positioning portions disposed on the second body, and a plurality of second sub-positioning portions disposed on the second body and next to the second main positioning portions to receive the container. The magnetic units disposed on the first main positioning portions and the second main positioning portions absorb magnetic material from the working fluid.
    Type: Grant
    Filed: April 17, 2007
    Date of Patent: June 22, 2010
    Assignee: Industrial Technology Research Institute
    Inventors: Chih Hsien Su, Hsiao Cheng Lin, Chi-Min Chau, Yuh-Jiuan Lin, Wen-Hsun Kuo
  • Patent number: 7579436
    Abstract: A peptide compound for measuring sulfur compound and ammonia and measurement method and device using the compound. The method comprises contacting an analyte with a sensory device coated with the peptide compound to produce a signal, processing the signal to produce a result, and comparing the result with a database to define the presence of the sulfur compound and ammonia in the analyte.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: August 25, 2009
    Assignee: Industrial Technology Research Institute
    Inventors: Pei-Ching Shih, Pei-Shin Jiang, Wen-Hsun Kuo, Yuh-Jiuan Lin
  • Publication number: 20090017518
    Abstract: A magnetic particle and fabrication method thereof. The magnetic particle comprises a polymer core, a magnetic material layer covering the polymer core, and a silicon containing layer covering the magnetic material layer. In addition, the magnetic particle may further comprise a coupling agent on the silicon containing layer, and an active molecule connected to the coupling agent. The magnetic particles provide controllable size, uniform diameter distribution, high magnetization, improved storage stability, and modified surface for targeting biomolecules for biomaterial separation and environmental analysis.
    Type: Application
    Filed: July 11, 2007
    Publication date: January 15, 2009
    Inventors: Kun Chan Wu, Hui-Ju Cho, Pei-Shin Jiang, Hsiang Yuan Huang, Wen-Hsun Kuo, Chi-Min Chau
  • Publication number: 20080156714
    Abstract: A magnetic separation device separating magnetic material from a working fluid of a container is disclosed. The magnetic separation device includes a first element, a second element and a magnetic assembly structure including a plurality of magnetic units. The first element includes a first body, a plurality of first main positioning portions disposed on the first body, and a plurality of first sub-positioning portions disposed on the first body and next to the first main positioning portions to receive the container. The second element includes a second body, a plurality of second main positioning portions disposed on the second body, and a plurality of second sub-positioning portions disposed on the second body and next to the second main positioning portions to receive the container. The magnetic units disposed on the first main positioning portions and the second main positioning portions absorb magnetic material from the working fluid.
    Type: Application
    Filed: April 17, 2007
    Publication date: July 3, 2008
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Chih Hsien Su, Hsiao Cheng Lin, Chi-Min Chau, Yuh-Jiuan Lin, Wen-Hsun Kuo
  • Publication number: 20080114152
    Abstract: A peptide compound for measuring sulfur compound and ammonia and measurement method and device using the compound. The method comprises contacting an analyte with a sensory device coated with the peptide compound to produce a signal, processing the signal to produce a result, and comparing the result with a database to define the presence of the sulfur compound and ammonia in the analyte.
    Type: Application
    Filed: March 1, 2007
    Publication date: May 15, 2008
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: PEI-CHING SHIH, Pei-shin Jiang, Wen-Hsun Kuo, Yuh-Jiuan Lin
  • Patent number: 7267989
    Abstract: A peptide compound for measuring sulfur compound and ammonia and measurement method and device using the compound. The method comprises contacting an analyte with a sensory device coated with the peptide compound to produce a signal, processing the signal to produce a result, and comparing the result with a database to define the presence of the sulfur compound and ammonia in the analyte.
    Type: Grant
    Filed: December 18, 2002
    Date of Patent: September 11, 2007
    Assignee: Industrial Technology Research Institute
    Inventors: Pei-Ching Shih, Pei-Shin Jiang, Wen-Hsun Kuo, Yuh-Jiuan Lin
  • Patent number: 7157269
    Abstract: The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing functional groups such as anhydride, imide, cyclic amide, and cyclic ester, and application of the hydrophobic copolymer onto an organic or inorganic substrate. The resulting slide has the properties of on-spot hydrophilic/hydrophobic dynamic conversion, as well as on-spot hydrophilic enhancement for the preparation of high-density and high-efficiency bio-chip/microarray.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: January 2, 2007
    Assignee: Industrial Technology Research Institute
    Inventors: Bor-Iaun Jan, Jia-Huey Tsao, Chih-Wei Ho, Yu-Ching Liu, Chao-Chi Pan, Zu-Sho Chow, Yao-Sung Chang, Cheng-Tao Wu, Wen-Hsun Kuo
  • Patent number: 6960468
    Abstract: The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing functional groups such as anhydride, imide, cyclic amide, and cyclic ester, and application of the hydrophobic copolymer onto an organic or inorganic substrate. The resulting slide has the properties of on-spot hydrophilic/hydrophobic dynamic conversion, as well as on-spot hydrophilic enhancement for the preparation of high-density and high-efficiency bio-chip/microarray.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: November 1, 2005
    Assignee: Industrial Technology Research Institute
    Inventors: Bor-Iuan Jan, Jia-Huey Tsao, Chih-Wei Ho, Yu-Ching Liu, Chao-Chi Pan, Zu-Sho Chow, Yao-Sung Chang, Cheng-Tao Wu, Wen-Hsun Kuo
  • Patent number: 6733894
    Abstract: The invention features a method for preparing a high-density functional slide by coating a sol-gel containing amine-group bearing silanes and a solution containing polyaldehyde groups onto an organic or inorganic substrate, respectively. The resulting slide is useful in the preparation of highly homogeneous functional-group slides and the high-density and high-efficiency bio-chip/microarray.
    Type: Grant
    Filed: September 19, 2002
    Date of Patent: May 11, 2004
    Assignee: Industrial Technology Research Institute
    Inventors: Chih-Wei Ho, Zu-Sho Chow, Bor-Iuan Jan, Jia-Huey Tsao, Chao-Chi Pan, Wen-Hsun Kuo, Yao-Sung Chang, Cheng-Tao Wu, Yu-Ching Liu
  • Publication number: 20040062854
    Abstract: The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing functional groups such as anhydride, imide, cyclic amide, and cyclic ester, and application of the hydrophobic copolymer onto an organic or inorganic substrate. The resulting slide has the properties of on-spot hydrophilic/hydrophobic dynamic conversion, as well as on-spot hydrophilic enhancement for the preparation of high-density and high-efficiency bio-chip/microarray.
    Type: Application
    Filed: September 26, 2003
    Publication date: April 1, 2004
    Inventors: Bor-Iuan Jan, Jia-Huey Tsao, Chih-Wei Ho, Yu-Ching Liu, Chao-Chi Pan, Zu-Sho Chow, Yao-Sung Chang, Cheng-Tao Wu, Wen-Hsun Kuo
  • Patent number: 6605363
    Abstract: The invention features a method for preparing a high-density functional slide by coating a sol-gel containing amine-group bearing silanes and a solution containing polyaldehyde groups onto an organic or inorganic substrate, respectively. The resulting slide is useful in the preparation of highly homogeneous functional-group slides and the high-density and high-efficiency bio-chip/microarray.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: August 12, 2003
    Assignee: Industrial Technology Research Institute
    Inventors: Chih-Wei Ho, Zu-Sho Chow, Bor-Iuan Jan, Jia-Huey Tsao, Chao-Chi Pan, Wen-Hsun Kuo, Yao-Sung Chang, Cheng-Tao Wu, Yu-Ching Liu
  • Publication number: 20030143750
    Abstract: A peptide compound for measuring sulfur compound and ammonia and measurement method and device using the compound. The method comprises contacting an analyte with a sensory device coated with the peptide compound to produce a signal, processing the signal to produce a result, and comparing the result with a database to define the presence of the sulfur compound and ammonia in the analyte.
    Type: Application
    Filed: December 18, 2002
    Publication date: July 31, 2003
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Pei-Ching Shih, Pei-Shin Jiang, Wen-Hsun Kuo, Yuh-Jiuan Lin
  • Publication number: 20030054434
    Abstract: The invention discloses a method for preparing an active slide, including introducing a monomer containing an aldehyde group, or a mixture of a monomer containing an aldehyde group and an acidic functional group provider into a plasma chamber; and depositing the aldehyde group and acidic functional group onto the surface of an organic or inorganic matrix using plasma deposition to form a slide comprising a layer of polymerized actively functional groups thereon. The aldehyde groups and negatively charged groups are deposited on the surface of the active slide, such that the bio-molecules bound thereto possess the properties of an inducible orientation and thus form a mono-layer.
    Type: Application
    Filed: November 6, 2002
    Publication date: March 20, 2003
    Inventors: Zu-Sho Chow, Jia-Huey Tsao, Wen-Hsun Kuo, Chih-Wei Ho, Bor-Iuan Jan, Chao-Chi Pan, Yao-Sung Chang, Cheng-Tao Wu, Yu-Ching Liu
  • Patent number: 6528291
    Abstract: A method is provided for preparing an active slide, including introducing a monomer containing an aldehyde group, or a mixture of a monomer containing an aldehyde group and an acidic functional group provider into a plasma chamber; and depositing the aldehyde group and acidic functional group onto the surface of an organic or inorganic matrix using plasma deposition to form a slide comprising a layer of polymerized actively functional groups thereon. The aldehyde groups and negatively charged groups are deposited on the surface of the active slide, such that the bio-molecules bound thereto possess the properties of an inducible orientation and thus form a mono-layer.
    Type: Grant
    Filed: September 11, 2000
    Date of Patent: March 4, 2003
    Assignee: Industrial Technology Research Institute
    Inventors: Zu-Sho Chow, Jia-Huey Tsao, Wen-Hsun Kuo, Chih-Wei Ho, Bor-Iuan Jan, Chao-Chi Pan, Yao-Sung Chang, Cheng-Tao Wu, Yu-Ching Liu
  • Publication number: 20030017560
    Abstract: The invention features a method for preparing a high-density functional slide by coating a sol-gel containing amine-group bearing silanes and a solution containing polyaldehyde groups onto an organic or inorganic substrate, respectively. The resulting slide is useful in the preparation of highly homogeneous functional-group slides and the high-density and high-efficiency bio-chip/microarray.
    Type: Application
    Filed: September 19, 2002
    Publication date: January 23, 2003
    Inventors: Chih-Wei Ho, Zu-Sho Chow, Bor-Iuan Jan, Jia-Huey Tsao, Chao-Chi Pan, Wen-Hsun Kuo, Yao-Sung Chang, Cheng-Tao Wu, Yu-Ching Liu
  • Publication number: 20020122875
    Abstract: The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing functional groups such as anhydride, imide, cyclic amide, and cyclic ester, and application of the hydrophobic copolymer onto an organic or inorganic substrate. The resulting slide has the properties of on-spot hydrophilic/hydrophobic dynamic conversion, as well as on-spot hydrophilic enhancement for the preparation of high-density and high-efficiency bio-chip/microarray.
    Type: Application
    Filed: May 2, 2002
    Publication date: September 5, 2002
    Inventors: Bor-Iuan Jan, Jia-Huey Tsao, Chih-Wei Ho, Yu-Ching Liu, Chao-Chi Pan, Zu-Sho Chow, Yao-Sung Chang, Cheng-Tao Wu, Wen-Hsun Kuo
  • Patent number: 6403368
    Abstract: The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing functional groups such as anhydride, imide, cyclic amide, and cyclic ester, and application of the hydrophobic copolymer onto an organic or inorganic substrate. The resulting slide has the properties of on-spot hydrophilic/hydrophobic dynamic conversion, as well as on-spot hydrophilic enhancement for the preparation of high-density and high-efficiency bio-chip/microarray.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: June 11, 2002
    Assignee: Industrial Technology Research Institute
    Inventors: Bor-Iuan Jan, Jia-Huey Tsao, Chih-Wei Ho, Chao-Chi Pan, Zu-Sho Chow, Yao-Sung Chang, Cheng-Tao Wu, Wen-Hsun Kuo