Abstract: An optical display apparatus is disclosed. A coupling apparatus couples light output by an image generation apparatus into an optical expansion waveguide. The optical expansion waveguide at least comprises a first reflective surface array and a second reflective surface array. Each reflective surface array is used for expanding, in an one-dimensional direction, light propagating through the optical expansion waveguide, so that the light entering into the optical expansion waveguide is expanded in a two-dimensional direction and is emitted outside of the optical expansion waveguide to form an image, wherein at least one of a first reflective surface of the first reflective surface array and a second reflective surface of the second reflective surface array is at least partially a curved surface, allowing the angle of emergence of the light to be changed by means of the first reflective surface or/and the second reflective surface.

Abstract: An optical expansion waveguide is disclosed that may comprise a first waveguide substrate (1) and a second waveguide substrate (2). The first waveguide substrate (1) allows the light entering the first waveguide substrate to expand in a first dimension direction, and the first waveguide substrate (1) comprises a plurality of first reflecting surfaces (101) arranged in sequence. The second waveguide substrate (2) allows the light entering the second waveguide substrate to expand in a second dimension direction, and the second waveguide substrate (2) comprises a plurality of second reflecting surfaces (201) arranged in sequence. At least one of the first reflecting surface (101) and the second reflecting surface (201) is at least partially curved so as to change an emission angle of light, such that the image distance of the image formed by the light emitted by the second waveguide substrate (2) meets the preset requirement.

Abstract: Scoring functions for predicting response of a dMMR and/or MSI-H colorectal tumor to a PD-1 axis-directed therapy are disclosed, as well as methods and systems for evaluating tissue samples for the presence of feature metrics useful in computing such scoring functions. The scoring functions integrate one or more spatial relationships between cell types into a numerical indication of the likelihood that the tumor will respond to the PD-1 axis-directed therapy. Based on the output of the scoring function, a subject may then be selected to receive a PD-1 axis-directed therapy (if the scoring function indicates a sufficient likelihood of positive response) or an alternative therapy (if the scoring function indicates an insufficient likelihood of positive response).

Abstract: Provided herein is a bispecific antibody and the use thereof. The bispecific antibody includes an antibody or antibody fragment; the antibody or the antibody fragment is a bispecific antibody or an antibody fragment comprising a first heavy chain, a first light chain, a second heavy chain, and a second light chain; the first Fab region comprises the first heavy chain and the first light chain; the second Fab region comprises the second heavy chain and the second light chain; and a variety of mutations are introduced in the first Fab region and the second Fab region.

Abstract: Provided in the present application are an MBS processing method, an MBS receiving apparatus and an MBS sending apparatus. The MBS processing method comprises: a base station generating suspension information and sending the suspension information to a UE, and the suspension information is configured to instruct the UE to suspend all radio bearers associated with an MBS, or is configured to instruct the UE not to suspend all the radio bears associated with the MBS, or is configured to instruct the UE to suspend some of the radio bearers associated with the MBS and not to suspend the remaining radio bearers among all the radio bearers; and each radio bearer associated with the MBS is an MRB. The MBS processing method includes generating a RRCRelease message and sending the RRCRelease message to a UE, and the RRCRelease message includes SuspendConfig information.

Abstract: A transceiving method includes the following steps. A receiving end receives a DRX command. A group-radio network temporary identifier scrambles a physical downlink control channel scheduling the DRX command. The receiving end uses a DRX cycle corresponding to the group-radio network temporary identifier for a multicast session corresponding to the group-radio network temporary identifier.

Abstract: A B7-H3 antibody and a use thereof are provided. The heavy chain complementarity determining regions of the B7-H3 antibody include the amino acid sequences shown in SEQ ID NOs. 6-8, and the light chain complementarity determining regions of the B7-H3 antibody include the amino acid sequences shown in SEQ ID NOs. 14-16. The B7-H3 antibody can bind to a B7-H3 antigen and/or cells expressing the B7-H3 antigen. A B7-H3×CD3 bispecific antibody is constructed by using the B7-H3 antibody.

Abstract: A multiple clip applier including a fixing handle, a conveying handle, a clamping handle, a pushing mechanism, a clip tube, a clip head and a closure clip assembly is provided. The clip head is arranged at one end of the clip tube, the clip tube is provided with a loading groove. The closure clip assembly is detachably arranged in the loading groove, and the clip tube includes an outer and an inner clip tube; the conveying handle and the clamping handle are both hinged with the fixing handle; and the clamping handle is linked with the outer clip tube to control opening or closing of the clip head. The closure clip assembly includes a plurality of closure clips; and the conveying handle is linked with the pushing mechanism to move along the length direction of the inner clip tube, thereby driving the closure clips to move towards the clip head.

Abstract: A scoring functions is developed and used for identifying patients who might be responsive to a PD-1 axis directed therapy. The scoring functions are obtained by extracting features from multiplex-stained sections, selecting features that correlate with response to the therapy using a feature selection function, and fitting one or more of the selected features to a plurality of candidate scoring functions. A candidate scoring function showing the desired balance between predictive sensitivity and specificity may then selected for incorporation into a scoring system that includes at least an image analysis system.

Abstract: A multi-source self-adaptive low-stress additive manufacturing method that includes arranging one or more high-energy sound beam excitation units on an additive manufacturing platform according to a size and a structure of a metal workpiece; planning an additive path according to the size and the structure of the workpiece; fixing a substrate on a self-adaptive additive manufacturing workbench; conducting additive manufacturing of the workpiece and starting a high-energy sound beam regulation system synchronously to generate high-energy sound beam(s) that are transmitted to the workpiece according to a control sequence; acquiring position information of molten pool(s) and position information of the one or more high-energy sound beam excitation units in the additive manufacturing process; continuously monitoring a surface temperature of the workpiece; and closing the high-energy sound beam regulation system when the additive manufacturing of the workpiece is finished and the surface temperature of the metal w

Abstract: The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.

Abstract: A multi-source self-adaptive low-stress additive manufacturing apparatus including a multi-axis manipulator additive manufacturing system, a high-energy sound beam regulation system, a substrate and a self-adaptive additive manufacturing workbench. The multi-axis manipulator additive manufacturing system includes multi-axis manipulator(s), welding torch(es), manipulator controller(s) and a guide rail, where base(s) of the multi-axis manipulator(s) is connected with the guide rail, the welding torch(es) is held by distal end(s) of the multi-axis manipulator(s), the multi-axis manipulator(s) is controlled by the manipulator controller(s) to move the welding torch(es) to conduct low-stress additive manufacturing on the workpiece to be additive manufactured.

Abstract: The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.

Abstract: A multi-source self-adaptive low-stress additive manufacturing apparatus including a multi-axis manipulator additive manufacturing system, a high-energy sound beam regulation system, a substrate and a self-adaptive additive manufacturing workbench. The multi-axis manipulator additive manufacturing system includes multi-axis manipulator(s), welding torch(es), manipulator controller(s) and a guide rail, where base(s) of the multi-axis manipulator(s) is connected with the guide rail, the welding torch(es) is held by distal end(s) of the multi-axis manipulator(s), the multi-axis manipulator(s) is controlled by the manipulator controller(s) to move the welding torch(es) to conduct low-stress additive manufacturing on the workpiece to be additive manufactured.

Abstract: Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics. The probes are particularly suited for detecting gene amplification, deletion, or rearrangement in tissue samples in a single, dual, or multiplexed assay. The probes exhibit improved performance compared to industry leading dual-stranded probes; particularly in terms of the rate of hybridization.

Abstract: A multi-source self-adaptive low-stress additive manufacturing method that includes arranging one or more high-energy sound beam excitation units on an additive manufacturing platform according to a size and a structure of a metal workpiece; planning an additive path according to the size and the structure of the workpiece; fixing a substrate on a self-adaptive additive manufacturing workbench; conducting additive manufacturing of the workpiece and starting a high-energy sound beam regulation system synchronously to generate high-energy sound beam(s) that are transmitted to the workpiece according to a control sequence; acquiring position information of molten pool(s) and position information of the one or more high-energy sound beam excitation units in the additive manufacturing process; continuously monitoring a surface temperature of the workpiece; and closing the high-energy sound beam regulation system when the additive manufacturing of the workpiece is finished and the surface temperature of the metal w

Abstract: The invention discloses a temperature control, optionally cooling, apparatus comprising: a first and second and/or plurality of fillable chambers each having a first layer, a second layer, an elongated edge, preferably longitudinal edge, an inlet and an outlet in the elongated, preferably longitudinal edge, and retention members between the first layer and second layer in a series of spaced veins creating a continuous channel extending from the inlet to the outlet; and a method of cooling and or maintaining an organ comprising: a method for cooling, warming and/or maintaining the temperature of an organ prior to or during a transplant procedure, the method comprising: contacting the organ with temperature control, optionally the cooling and/or temperature maintaining, apparatus; securing the apparatus to the organ; attaching the inlets of the first and second and/or plurality of fillable chambers of the apparatus to a circulation fluid source; and/or infusing circulation fluid into the inlet, through the cont

Abstract: Provided are a preamble symbol receiving method and device, characterizing in that the method comprises the following steps: processing a received signal; judging whether the processed signal obtained contains the preamble symbol desired to be received; and if a judgement result is yes, determining the position of the preamble symbol and resolving signalling information carried by the preamble symbol, wherein the received preamble symbol comprises at least one time-domain symbol generated by a transmitting end using a free combination of any number of first three-segment structures and/or second three-segment structures according to a predefined generation rule, the first three-segment structure containing: a time-domain main body signal, a prefix generated based on the entirety or a portion of the time-domain main body signal, and a postfix generated based on the entirety or a portion of a partial time-domain main body signal, and the second three segment structure containing: the time domain main body signa

Abstract: An instrument and a method for simultaneously testing a molecular weight distribution and an organic nitrogen level of a water sample are provided. The instrument comprises: a tail-end injection valve, a chromatographic column, a pressure relief valve, an acid-adding injection valve, an oxygen-adding injection valve, a helical tube for an acid-oxygen reaction, a CO2 remover, a UV digester, a second gas-water separator membrane, a buffer solution injection valve, a helical tube for a buffer solution reaction, a cadmium column, a chromogenic agent injection valve, a helical tube for a chromogenic agent reaction, and a UV detector, sequentially connected via a pipeline. The tail-end injection valve is for receiving a fluid phase and a sample. The second gas-water separator membrane is connected to an electrical conductivity-based CO2 detector. The UV detector and the electrical conductivity-based CO2 detector are connected to a data processing computer.

Abstract: Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics. The probes are particularly suited for detecting gene amplification, deletion, or rearrangement in tissue samples in a single, dual, or multiplexed assay. The probes exhibit improved performance compared to industry leading dual-stranded probes; particularly in terms of the rate of hybridization.