Abstract: A photo frame structure includes a frame, an outer clipping layer and an inner clipping layer. The frame includes a viewing window at the front side of the frame and a plurality of side bars for enclosing the frame, a groove formed at an internal side of each side bar, and a sheet glass installed into the groove and attached onto the viewing window. The outer clipping layer is stacked with the frame and pivotally coupled to a lateral side of the frame, and another lateral side has a clasp module, and a containing space is concavely disposed on a lateral surface of the outer clipping layer for containing an inner clipping layer, and a lateral surface of the inner clipping layer corresponding to the outer clipping layer has a photo containing slot for containing several photos, so as to facilitate the change or storage of photos.