Patents by Inventor Wen-Lin P. Tsai

Wen-Lin P. Tsai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110288023
    Abstract: The invention provides modified Transferrin (Tf) molecules and conjugates of the Tf molecules with a therapeutic agent. The invention also provides methods of treating cancer wherein the therapeutic agents are chemotherapeutic agents. The modified Tf molecules improve the delivery of the conjugated agent to a target tissue. In some embodiments, the modified Tf molecule has a mutation which decreases the release of bound iron from a Tf complex. The complex can also contain, for instance, a carbonate, oxalate, or other anion to stabilize the Tf iron complex.
    Type: Application
    Filed: December 6, 2010
    Publication date: November 24, 2011
    Applicants: The Regents of the University of California Office of Technology Transfer, Office of Technology Transfer, University of Vermont
    Inventors: Daniel T. Kamei, Bert J. Lao, Wen-Lin P. Tsai, Foad Mashayekhi, Edward A. Pham, Anne B. Mason
  • Publication number: 20090181048
    Abstract: The present invention provides transferrin (Tf) conjugates of anti-cancer agents with increased cellular association and increased cellular internalization. The present invention also provides methods of treating cancer comprising administration of a Tf conjugate with increased cellular association to a subject with cancer. The present invention additionally provides methods of making, as well as screening for, Tf conjugates with increased cellular association or cellular internalization. The present invention also provides Tf conjugates with increased cellular association and internalization for delivering nucleic acids to cancer cells.
    Type: Application
    Filed: June 6, 2008
    Publication date: July 16, 2009
    Applicant: The Regents of the University of California
    Inventors: Daniel T. Kamei, Bert J. Lao, Wen-Lin P. Tsai, Foad Mashayekhi, Edward A. Pham, Anne B. Mason