Abstract: The present invention discloses a polypeptide and application thereof. By modifying oxyntomodulin (OXM), hybridizing OXM with a peptide sequence of Exenatide, including enabling the polypeptide to be resistant to DPP-4 enzyme degradation through amino acid modification, and conjugating fatty acid chains at the same time, an OXM hybrid peptide having longer pharmacologic action time and better weight losing effects is obtained. Synthesis of a target polypeptide is fast realized by an orthogonal protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the OXM hybrid peptide.

Abstract: The present invention relates to a novel phenoxyacetic acid derivative represented by the general formula (I), preparation method thereof and use of a pharmaceutical composition containing the derivative in preparing a medicament for treating diabetes and metabolic syndrome. The phenoxyacetic acid derivatives have excellent in vivo hypoglycemic activity, which can be used for preventing or treating diabetes.

Abstract: New benzodiazepine compounds, and a preparation method therefor and the use thereof are provided. Short-acting benzodiazepine derivatives have the characteristics of a fast onset, short acting time, deep strength, being quickly metabolized, fast wake-up, etc. In anesthesia experiments on mice and rats, short-acting benzodiazepine derivatives have a comparable onset time to remazolam, but have a significantly shortened acting time and wake-up time. Moreover, some of the compounds have a significantly enhanced depth of action. Thus, the compounds have the characteristics of a faster onset, shorter acting time, greater strength of action, being metabolized faster, faster wake-up, etc. In long-term infusion anesthesia experiments on rats, compared with remazolam, the short-acting benzodiazepine derivatives have a significantly shortened wake-up time and recovery time, and have the characteristics of faster wake-up, a faster recovery, etc.

Abstract: The present invention discloses a polypeptide and application thereof. By modifying oxyntomodulin (OXM), hybridizing OXM with a peptide sequence of Exenatide, including enabling the polypeptide to be resistant to DPP-4 enzyme degradation through amino acid modification, and conjugating fatty acid chains at the same time, an OXM hybrid peptide having longer pharmacologic action time and better weight losing effects is obtained. Synthesis of a target polypeptide is fast realized by an orthogonal protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the OXM hybrid peptide.

Abstract: The present invention relates to a novel phenoxyacetic acid derivative represented by the general formula (I), preparation method thereof and use of a pharmaceutical composition containing the derivative in preparing a medicament for treating diabetes and metabolic syndrome. The phenoxyacetic acid derivatives have excellent in vivo hypoglycemic activity, which can be used for preventing or treating diabetes.

Abstract: A transaction processing method, an apparatus, and a computer system are provided. According to the method, after receiving a transaction processing request, status information of the transaction is recorded in a non-volatile memory, where the transaction processing request carries transaction data of a transaction, where the status information of the transaction includes a transaction status, a transaction identifier, and an address, and where the transaction status is an uncommitted state. The transaction data is written to the non-volatile memory according to the address. Then, the transaction status of the transaction is modified to a committed state according to the transaction identifier. Further, after writing the transaction data to an external memory of the computer system from the non-volatile memory, the transaction status of the transaction is modified to a backup state according to the transaction identifier. A transaction data processing speed can be increased in the foregoing manner.

Abstract: The present disclosure provides a tea machine dripping and brewing tea with cold water, including a water storage tank, dripping pipe, tea cake rack, cup holder and a main control unit. One end of the dripping pipe is connected with the bottom of the water storage tank, and the other end is an open end. A drip controller is installed on the dripping pipe. The cup holder is located right below the tea cake rack for placing a metering cup, and is provided with a water cup detecting apparatus and a water quantity detecting apparatus. The main control unit is connected with the drip controller, the water cup detecting apparatus and the water quantity detecting apparatus, and commands opening and closing of the drip controller, so as to brew tea with cold water to dissolve out effective ingredients of the tea.

Abstract: A storage space management method and apparatus, where the method and apparatus are applied to a non-volatile memory (NVM). In a feature set that includes M image features of M idle blocks in storage space of the NVM, an idle block whose image feature is highly similar to an image feature of data to be written into the NVM is determined such that the data is written into the idle block. In this way, wear and energy consumption problems are considered during storage space allocation, and a write operation of an idle block in storage space of an NVM can consume less energy, thereby extending a life span of the NVM and reducing write operation energy consumption.

Abstract: A lock management method and system, and a method and an apparatus for configuring a lock management system is provided. A corresponding level of a lock management system is set for each service execution node according to the number of service execution nodes included in a distributed system, the number of system instances on all service execution nodes, the number of handling processes on all the service execution nodes, and a delay of access of each service execution node to a central control node of the distributed system. At least one lock manager is allocated to each service execution node separately according to the level, which is corresponding to each service execution node, of the lock management system. A lock level context is configured for each lock manager, where the lock level context is used to determine an adjacent lock manager of each lock manager.

Abstract: A transaction processing method, an apparatus, and a computer system are provided. According to the method, after receiving a transaction processing request, status information of the transaction is recorded in a non-volatile memory, where the transaction processing request carries transaction data of a transaction, where the status information of the transaction includes a transaction status, a transaction identifier, and an address, and where the transaction status is an uncommitted state. The transaction data is written to the non-volatile memory according to the address. Then, the transaction status of the transaction is modified to a committed state according to the transaction identifier. Further, after writing the transaction data to an external memory of the computer system from the non-volatile memory, the transaction status of the transaction is modified to a backup state according to the transaction identifier. A transaction data processing speed can be increased in the foregoing manner.

Abstract: A storage space management method and apparatus, where the method and apparatus are applied to a non-volatile memory (NVM). In a feature set that includes M image features of M idle blocks in storage space of the NVM, an idle block whose image feature is highly similar to an image feature of data to be written into the NVM is determined such that the data is written into the idle block. In this way, wear and energy consumption problems are considered during storage space allocation, and a write operation of an idle block in storage space of an NVM can consume less energy, thereby extending a life span of the NVM and reducing write operation energy consumption.

Abstract: A lock management method and system, and a method and an apparatus for configuring a lock management system is provided. A corresponding level of a lock management system is set for each service execution node according to the number of service execution nodes included in a distributed system, the number of system instances on all service execution nodes, the number of handling processes on all the service execution nodes, and a delay of access of each service execution node to a central control node of the distributed system. At least one lock manager is allocated to each service execution node separately according to the level, which is corresponding to each service execution node, of the lock management system. A lock level context is configured for each lock manager, where the lock level context is used to determine an adjacent lock manager of each lock manager.

Abstract: The present invention provides a method and a system for configuring a storage device in a hybrid storage environment. The method includes: acquiring a plurality of attribute parameters of each storage device; performing calculation according to the attribute parameters to obtain a priority of each storage device; acquiring a storage priority of each data object; and performing matching according to the storage priority of each data object and the priority of each storage device, so as to store each data object into a storage device with a priority corresponding to the storage priority of the data object. Accordingly, configuration of a plurality of storage devices and a plurality of data objects in a hybrid storage environment can be implemented, which avoids manual involvement, thereby reducing security risks, improving performance of the system, and reducing energy consumption of the system.

Abstract: The present invention provides a method and a system for configuring a storage device in a hybrid storage environment. The method includes: acquiring a plurality of attribute parameters of each storage device; performing calculation according to the attribute parameters to obtain a priority of each storage device; acquiring a storage priority of each data object; and performing matching according to the storage priority of each data object and the priority of each storage device, so as to store each data object into a storage device with a priority corresponding to the storage priority of the data object. Accordingly, configuration of a plurality of storage devices and a plurality of data objects in a hybrid storage environment can be implemented, which avoids manual involvement, thereby reducing security risks, improving performance of the system, and reducing energy consumption of the system.

Abstract: A tetrahydroprotoberberine quaternary ammonium compound represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R' and X are as defined in the specification. A method of preparing the compound is provided. The compounds can suppress arrhythmia and ventricular fibrillation, protect against myocardial ischemia, and can be conveniently orally administered.