Patents by Inventor Wen-Pin Tzeng

Wen-Pin Tzeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Highly infectious rubella virus DNA constructs and methods of production
    Patent number: 6958237
    Abstract: Highly infectious rubella virus cDNA clones derived from infectious cDNA clone having a low specific infectivity and methods of obtaining highly infectious rubella virus cDNA clones. Togavirus expression vectors of improved stability for the expression of live, attenuated togavirus and a foreign gene, based on the nucleic acid sequence of an infectious rubella virus clone and contain a togavirus non-structural protein open reading frame; an expression element for expression of a foreign gene; a foreign gene or a multiple cloning site for insertion of a foreign gene; an expression element for the expression of the live, attenuated togavirus; and a togavirus structural protein open reading frame. The expression element is either a subgenomic promoter or an internal ribosome entry site (IRES). Administration of the vector as an immunization agents is useful for the induction of immuity against the togavirus, the foreign gene, or both.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: October 25, 2005
    Assignee: Georgia State Univesity Research Foundation, Inc.
    Inventors: Teryl K. Frey, Konstantin V. Pugachev, Emily S. Abernathy, Wen-Pin Tzeng
  • Highly infectious rubella virus DNA constructs and methods of production
    Publication number: 20030215795
    Abstract: Highly infectious rubella virus cDNA clones derived from infectious cDNA clone having a low specific infectivity and methods of obtaining highly infectious rubella virus cDNA clones. Togavirus expression vectors of improved stability for the expression of live, attenuated togavirus and a foreign gene, based on the nucleic acid sequence of an infectious rubella virus clone and contain a togavirus non-structural protein open reading frame; an expression element for expression of a foreign gene; a foreign gene or a multiple cloning site for insertion of a foreign gene; an expression element for the expression of the live, attenuated togavirus; and a togavirus structural protein open reading frame. The expression element is either a subgenomic promoter or an internal ribosome entry site (IRES). Administration of the vector as an immunization agents is useful for the induction of immuity against the togavirus, the foreign gene, or both.
    Type: Application
    Filed: February 24, 2003
    Publication date: November 20, 2003
    Inventors: Teryl K. Frey, Konstantin V. Pugachev, Emily S. Abernathy, Wen-Pin Tzeng
  • Highly infectious rubella virus DNA constructs and methods of production
    Publication number: 20030130498
    Abstract: Highly infectious rubella virus cDNA clones derived from infectious cDNA clone having a low specific infectivity and methods of obtaining highly infectious rubella virus cDNA clones. Togavirus expression vectors of improved stability for the expression of live, attenuated togavirus and a foreign gene, based on the nucleic acid sequence of an infectious rubella virus clone and contain a togavirus non-structural protein open reading frame; an expression element for expression of a foreign gene; a foreign gene or a multiple cloning site for insertion of a foreign gene; an expression element for the expression of the live, attenuated togavirus; and a togavirus structural protein open reading frame. The expression element is either a subgenomic promoter or an internal ribosome entry site (IRES). Administration of the vector as an immunization agents is useful for the induction of immuity against the togavirus, the foreign gene, or both.
    Type: Application
    Filed: October 15, 2002
    Publication date: July 10, 2003
    Inventors: Teryl K. Frey, Konstantin V. Pugachev, Emily S. Abernathy, Wen-Pin Tzeng