Abstract: A home appliance control system is provided. The home appliance control system includes a portable device and a home appliance device. The portable device includes a first microphone, a first speaker, and a first processor. The first processor provides a first packet formed by a plurality of first audio signals through the first speaker according to an instruction. The home appliance device includes a second microphone, a second speaker, and a second processor. The second microphone receives the first packet from the first speaker of the portable device. The second processor obtains the instruction according to the first audio signals of the first packet received by the second microphone, and controls the home appliance device to perform an operational program according to the instruction.