Abstract: The present invention provides single chain T cell engager (TCE) molecules having an scFab that binds a target antigen and an scFv that binds CD3, and TCE molecules that bind CCR8 and CD3. Methods of treating cancer are also provided.

Abstract: The present invention provides anti-CCR8 antibodies and antigen-binding fragments thereof, and methods of making and using said anti-CCR8 antibodies and antigen-binding fragments thereof.

Abstract: Embodiments of the present application provide a battery pressing device, including: a first pressing mechanism for pressing a battery in a first direction; and a second pressing mechanism for pressing the battery in a second direction perpendicular to the first direction. With the battery pressing device of the present application, the battery can be pressed in the first direction by using the first pressing mechanism while pressing the battery in the second direction by using the second pressing mechanism, thereby reducing or suppressing the undesired deformation of the battery in the second direction and improving the flatness of the battery in the second direction.

Abstract: An OCV detection method comprises: performing OCV detection on to-be-detected materials, wherein to-be-detected battery materials are transported to an OCV detection location for detection, and when the detection result is unqualified, all the materials are transported to a replacement location; performing OCV detection on transferred materials, wherein the OCV detection is performed on transferred battery materials at a transfer station, and the quantity of the detected transferred battery materials is one or more; and performing primary battery replacement. Ater the OCV detection, defective products in the to-be-detected battery materials are transferred to the transfer station, and good products in the transferred battery materials are transferred to the replacement location.

Abstract: The present application discloses a gripping mechanism, a loading device and a loading control method. The gripping mechanism includes a base body and a first gripping assembly. A clamping zone is configured on one side of the base body. The first gripping assembly includes a first jaw and a second jaw, with the first jaw being arranged on one of two opposite sides of the clamping zone, and the second jaw being arranged on the other side; wherein at least one of the first jaw and the second jaw is movably connected to the base body, such that a spacing between the first jaw and the second jaw is adjustable, so that the requirements for gripping plates of different specifications and sizes can be met. That is, the gripping mechanism according to embodiments of the present application can be compatible with plates of different specifications and sizes.

Abstract: A system level search module receives system level search user interface registration information for an application of the computing device. The registration information includes an indication of how the system level search module can launch the application. The registration information is added to a registration store, and the application is included as one of one or more applications that can be searched using the system level search user interface.

Abstract: A method for determining a column-hemispherical permeation radius with time-varying property of power-law cement grout and tortuosity of rock and soil mass is provided, including: acquiring a porosity ? of rock and soil mass and a corresponding permeation coefficient K by geotechnical tests, measuring a groundwater pressure P0 at a grouting point and determining tortuosity ? of rock and soil mass; acquiring an initial consistency coefficient c0, a rheological index n and a time-varying property coefficient k of power-law cement grout with a designed water to cement ratio by rheological tests, and determining the viscosity of water ?w; acquiring grouting parameters, including a grouting pressure P1, grouting time t, a number m of grouting holes of a side surface of a grouting pipe and a grouting hole radius r; and solving a column-hemispherical permeation grouting diffusion radius R considering coupling effect both the tortuosity of rock and soil mass and the time-varying property of power-law cement grout.

Abstract: A system level search module receives system level search user interface registration information for an application of the computing device. The registration information includes an indication of how the system level search module can launch the application. The registration information is added to a registration store, and the application is included as one of one or more applications that can be searched using the system level search user interface.

Abstract: A system level search module receives system level search user interface registration information for an application of the computing device. The registration information includes an indication of how the system level search module can launch the application. The registration information is added to a registration store, and the application is included as one of one or more applications that can be searched using the system level search user interface.

Abstract: The present invention provides anti-CCR8 antibodies and antigen-binding fragments thereof, and methods of making and using said anti-CCR8 antibodies and antigen-binding fragments thereof.

Abstract: Described herein are compounds comprising a biologically active organic core group with one to five —Z—(X1—S(O)(X2)F)m groups attached thereto, wherein Z is O, NR, or N; X1 is a covalent bond or CH2CH2; m can be 1 or 2 depending on the identity of Z; and X2 is O or NR. In some embodiments, the core group is an amino acid or a protein. In some embodiments the core group is a compound that has therapeutic activity toward a therapeutic target.

Abstract: This application describes modified amino acids and polypeptides comprising a SO2F or CH2CH2SO2F group bound to the side chain of an amono acid or amino acid residue of a polypeptide in place of a hydrogen of a hydroxyl or amino substituent thereof. Methods of covalently binding the polypeptides to receptot sites of receptor proteins are also described herein.

Abstract: This application describes a compound represented by Formula (I): wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X1 is a covalent bond or —CH2CH2—, X2 is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.

Abstract: This application describes a compound represented by Formula (I): wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X1 is a covalent bond or —CH2CH2—, X2 is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.

Abstract: This application describes a compound represented by Formula (I): YZX1—S(O)(X2)F)m]n??(I) wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X1 is a covalent bond or —CH2CH2—, X2 is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.

Abstract: The disclosure describes a yarn twisting machine in which a hollow spindle rod is fixedly connected with a motor that drives the hollow spindle rod to rotate, a twisting disc and a yarn storage disc are fixedly connected with the hollow spindle rod and rotate along with the hollow spindle rod, the yarn storage disc is provided with yarn outlets, which communicate with inner yarn channels of the hollow spindle rod spindle tanks for accommodating inner yarn packages are connected with the hollow spindle rod through spindle rod bearings, and the spindle tanks are immobile.

Abstract: This application describes a compound represented by Formula (I): Y?Z?X1—S(O)(X2)F)m]n??(I) wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X1 is a covalent bond or —CH2CH2—, X2 is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.

Abstract: The present invention relates to a carpet yarn twisting machine, comprising a machine frame, a creel unit (1), an electric spindle unit (5), an overfeeding unit (4) and a reeling unit (3), in the electric spindle unit (5), a hollow spindle rod (502) is fixedly connected with a motor (501), the motor (501) drives the hollow spindle rod (502) to rotate, a twisting disc (506) and a yarn storage disc (505) are fixedly connected with the hollow spindle rod (502) and rotate along with the hollow spindle rod (502), the yarn storage disc (505) is provided with yarn outlets (504), which communicate with inner yarn channels of the hollow spindle rod (502), spindle tanks for accommodating inner yarn packages (15) are connected with the hollow spindle rod (502) through spindle rod bearings (509), and the spindle tanks are immobile.

Abstract: A system level search module receives system level search user interface registration information for an application of the computing device. The registration information includes an indication of how the system level search module can launch the application. The registration information is added to a registration store, and the application is included as one of one or more applications that can be searched using the system level search user interface.

Abstract: This application describes a compound represented by Formula (I): (I) wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X1 is a covalent bond or —CH2CH2—, X2 is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.