Abstract: Disclosed herein are methods for isolating antibody-producing cells that express antibody molecules specific for an interface between a target peptide and an MHC molecule. The methods disclosed herein utilize a blocking reagent when sorting cells such as splenocytes which permits enrichment of cells expressing rare antibody molecules that specifically recognize an MHC-peptide interface.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Abstract: Computational systems and methods for predicting amino acid position(s) within a target peptide presented in a complex with a major histocompatibility complex (MHC) molecule (MHC-target peptide complex), the amino acid position(s) being involved in interacting with an antigen-recognition molecule that recognizes said MHC-target peptide complex, are presented herein. Computational systems and methods for estimating a number of off-target peptide(s) for an antigen-recognition molecule that recognizes a target peptide presented in a complex with a major histocompatibility complex (MHC) molecule (MHC-target peptide complex) is presented herein. Computational systems and methods for ranking potential target peptides to mitigate off-target toxicity are presented herein. Such computational systems and methods can streamline development of effective, well tolerated antigen-recognition molecules to treat diseases.

Abstract: Disclosed herein are methods for obtaining antibody-producing cells that express antibody molecules exhibiting high binding affinity for an antigen which comprise contacting a population of antibody-producing cells encompassing cells that express antibody molecules to the antigen on the cell surface, with a first labeled form of the antigen to allow the antigen to bind to the antibody molecules on the cell surface, followed by contacting the cells with (i) an unlabeled form of the antigen, (ii) a second labeled form of the antigen, or (iii) the unlabeled form of the antigen and the second labeled form of the antigen; and collecting cells that remain bound to the first labeled form of the antigen, thereby obtaining cells expressing high affinity antibody molecules to the antigen. The present methods allow for obtaining cells expressing high affinity antibody molecules from a pool of antibody-producing cells that express antibody molecules with different affinities.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Abstract: The present disclosure provides antibody capture complexes and methods of capturing a target antibody secreted by an antibody secreting cell.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Abstract: Disclosed are methods for obtaining cells that express antibodies that bind transmembrane proteins, methods for generating antibodies from such cells, antibodies to transmembrane proteins and fragments thereof, and nucleic acids encoding the antibodies. More particularly, the disclosure relates to methods for obtaining antibody-producing cells that express an antibody that binds to a transmembrane protein based on the use of lipid bilayer-membrane scaffold protein complexes to present transmembrane protein antigens to cells.

Abstract: The present invention provides isolated T cell receptors (TCRs) that specifically bind to an HLA-displayed New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1) peptides, as well as therapeutic and diagnostic methods of using those isolated TCRs.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Abstract: An assembling buckle structure for memory circuit board includes: a base, two sides thereof are respectively formed with an elastic lateral plate having at least a buckle part, two ends of the lateral plate is formed with at least an outer mounting convex and a fasten post, the rear end of the base is formed with a tail plate having at least a buckle part; a memory circuit board disposed in the base, the front end thereof is formed with a connection seat; and a cover, covered and engaged with the base, the front end thereof is formed with a penetrated hole, two inner ends thereof are formed with at least an inner mounting concave; accordingly, the memory circuit board, the base and the cover are able to be stably buckled and combined in any direction without using any screw.

Abstract: An active stylus that is applicable to a touch panel. The touch panel comprises driving electrodes and sensing electrodes. Each driving electrode transmits a panel driving signal. The sensing electrodes receive the panel driving signal. The active stylus comprises a receiving element receiving the panel driving signal; a sensing module obtaining signal characteristics of the panel driving signal; a signal generator generating a simulated driving signal; a driving element transmitting the simulated driving signal; and a control unit. The control unit uses the signal generator to generate the simulated driving signal, which is synchronous with and identical in phase to the panel driving signal, according to the signal characteristics of the panel driving signal. Thereby, the touch panel can distinguish the touch of an active stylus from the touch of a hand and realize a multi-point touch control function in a mutual-capacitance mode.

Abstract: A noise reduction capacitive touch panel comprises a sensing area, a non-sensing area, a main body, a plurality of driving electrodes, a plurality of driving electrode wires, a plurality of sensing electrodes, a plurality of sensing electrode wires, at least one noise sensing electrodes and at least noise sensing electrode wires. The sensing area is located in the middle of the panel and the rest area of the panel is the non-sensing area. The main body is a flat board having a normal line. The driving electrodes are strip electrodes and disposed on the main body. The driving electrodes are perpendicular to the normal line. The driving electrodes wires are disposed on the main body. The sensing electrodes are strip electrodes and disposed on the main body. Capacitive coupling is occurred between the driving electrodes and the sensing electrodes because there is a distance between them.

Abstract: A projected capacitive touch panel comprises a touch control integrated circuit, sensing electrodes, driving electrodes, a MCU, a AC signal generator, a sensing bus, and a driving bus. The driving electrodes are made of high resistance material. One driving electrodes is selected by MCU based on firmware program as selected driving electrode. A low voltage AC signal is generated by the AC signal generator. The AC signal is transmitted to the selected driving electrode and its adjacent two driving electrodes via the driving bus. The rest of driving electrodes are connected to a fixed DC level. Providing the same AC signal to three driving electrodes simultaneously can induce higher sensing signal in the sensing electrodes.

Abstract: A projected capacitive touch panel comprises a touch control integrated circuit, sensing electrodes, driving electrodes, a MCU, a AC signal generator, a sensing bus, and a driving bus. The driving electrodes are made of high resistance material. One driving electrodes is selected by MCU based on firmware program as selected driving electrode. A low voltage AC signal is generated by the AC signal generator. The AC signal is transmitted to the selected driving electrode and its adjacent two driving electrodes via the driving bus. The rest of driving electrodes are connected to a fixed DC level. Providing the same AC signal to three driving electrodes simultaneously can induce higher sensing signal in the sensing electrodes.

Abstract: A memory heatsink set for dissipating heat from a memory module is disclosed to include a first memory heatsink and a second memory heatsink, two guide devices bilaterally provided between the first memory heatsink and the second memory heatsink for positioning during the assembly process of the memory heatsink set and for guiding the first memory heatsink and the second memory heatsink into alignment, and two supplementary retaining devices respectively provided at two ends between the first memory heatsink and the second memory heatsink, each supplementary retaining device having a main engagement opening and two lateral sub-engagement openings located on one end of the first memory heatsink and a main engagement block and two lateral sub-engagement blocks located on the corresponding end of the second memory heatsink for engaging the main engagement opening and the two lateral sub-engagement openings respectively.

Abstract: An interlocking structure is arranged on two separable heat dissipating plates that together form a memory heat sink, and includes two elongated flanges, at least two locating tabs, at least one catch tab, at least one expanded head portion, at least one retaining slot in a number corresponding to the expanded head portion, and at least one stopper. Two sets of the interlocking structure are diagonally symmetrically provided near two opposite ends of the two heat dissipating plates. Once the expanded head portions have been extended through the retaining slots and the two heat dissipating plates are outward turned relative to each other, the locating tabs and the expanded head portions will firmly hook to the stoppers and the catch tabs, respectively, without the risk of separating from the retaining slots due to turning open or close, vibrating, or impacting of the two heat dissipating plates.