Abstract: Provided herein is a process for preparing a microparticulate complex of a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible organic solvent. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component, and a composition comprising water and the microparticulate complex. Further provided is a method of delivery of a nucleic acid-like component to a cell or to a patient by contacting the cell with or administering to the patient a composition comprising water and the microparticulate complex described herein. Still further, a charge-changing composition represented by the formula A-X—B is provided.

Abstract: A process for preparing a microparticulate complex is provided. The process comprises (a) combining a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible, organic solvent to form a mixture wherein the PFC and the NAC are independently molecularly or micellarly soluble in the aqueous/organic solvent system, and (b) reducing the amount of the organic solvent in the mixture. This effects formation of the microparticulate complex of the NAC and the PFC. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component forming an approximately spherical particle, wherein the particle-forming component encloses an interior of the particle containing the nucleic acid-like component and the so-enclosed interior volume has less than about 50% (preferably less than 20%) of the volume containing free water.

Abstract: Provided is a method that achieves control of embryoid body size and can induce differentiation in a state where the embryoid body size is controlled, by using a cell culture chamber having a plurality of microchambers formed therein. A culture method for causing differentiation of pluripotent mammalian cells uses a cell culture chamber (10) having a plurality of microchambers (11) formed on a culture surface. The cell culture chamber (10) has a culture surface formed of spaces in which the microchambers (11) have a space structure with a height of 10 ?m to 500 ?m and a bottom area of 100 ?m2 to 1 mm2. The culture method for causing differentiation of pluripotent mammalian cells includes culturing pluripotent mammalian cells to obtain a cell population at least partially differentiated into endoderm lineage cells, by using the cell culture chambers (10).

Abstract: A display device includes a display unit, a touch unit, a backlight unit and an electrophoresis unit. The touch unit is disposed over the display unit, the backlight unit is disposed under the display unit and the electrophoresis unit is disposed on the display unit, in which the electrophoresis unit includes a substrate, multiple display electrodes, at least one storage electrode, a gate electrode and multiple charged particles. The substrate has an active region and a peripheral region connecting the active region, the display electrodes are disposed at the active region of the substrate and arranged in a same interval, the storage electrode is disposed at the peripheral region of the substrate, the gate electrode is disposed at the peripheral region of the substrate and located between the display electrodes and the storage electrode, and the charged particles are disposed on the substrate have with mirror reflective property.

Abstract: A transflective display device of the present invention includes a backlight module, an electrophoretic device, and a liquid crystal panel. The electrophoretic device includes a first substrate; a second substrate; an electrophoretic layer; a collector; a gate electrode and a plurality of transparent electrodes. The first substrate has at least a pixel region, and a device region and a display region are defined in the pixel region. The first substrate is disposed oppositely to the second substrate, and the electrophoretic layer is disposed between the first substrate and the second substrate. The electrophoretic layer includes a transparent fluid and a plurality of opaque charged particles. The collector, the gate electrode, and the plurality of transparent electrodes are disposed between the first substrate and the second substrate, wherein the collector and the gate electrode are disposed in the device region and the transparent electrodes are disposed in the display region.

Abstract: A transflective display device of the present invention includes a backlight module, an electrophoretic device, and a liquid crystal panel. The electrophoretic device includes a first substrate; a second substrate; an electrophoretic layer; a collector; a gate electrode and a plurality of transparent electrodes. The first substrate has at least a pixel region, and a device region and a display region are defined in the pixel region. The first substrate is disposed oppositely to the second substrate, and the electrophoretic layer is disposed between the first substrate and the second substrate. The electrophoretic layer includes a transparent fluid and a plurality of opaque charged particles. The collector, the gate electrode, and the plurality of transparent electrodes are disposed between the first substrate and the second substrate, wherein the collector and the gate electrode are disposed in the device region and the transparent electrodes are disposed in the display region.

Abstract: The present invention provides a human hepatic stem cell which is sorted based on the presence or absence of the expression of at least one marker selected from the group consisting of CD318, CD90, CD66 and CD13. A method of preparing the human hepatic stem cell, a method of inducing differentiation of the same and a method of using the same are also provided.

Abstract: Provided is a cell culture method whereby an in vivo function can be sustained over a long period of time and culture can be conducted using the minimum number of cells required. The cell culture method includes culturing undifferentiated cells in a layered state in a partitioned micro-space and obtains differentiated cells. When screening a pharmaceutical agent, undifferentiated cells capable of differentiating into liver cells, intestinal epithelial cells, nerve cells, myocardial cells and vascular endothelial cells are preferred. Particularly, in the prediction of pharmacokinetics or the like for humans, human cells are preferred.

Abstract: A process for preparing a microparticulate complex is provided. The process comprises (a) combining a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible, organic solvent to form a mixture wherein the PFC and the NAC are independently molecularly or micellarly soluble in the aqueous/organic solvent system, and (b) reducing the amount of the organic solvent in the mixture. This effects formation of the microparticulate complex of the NAC and the PFC. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component forming an approximately spherical particle, wherein the particle-forming component encloses an interior of the particle containing the nucleic acid-like component and the so-enclosed interior volume has less than about 50% (preferably less than 20%) of the volume containing free water.

Abstract: Embodiments in accordance with the present invention provide methods of forming a metal interconnect structure which avoid defects arising from copper migration. In accordance with particular embodiments, an electroplated copper feature is subjected to a brief thermal anneal prior to chemical mechanical polishing and subsequent formation of an overlying barrier layer. This thermal anneal intentionally provokes migration of the copper and resulting formation of hillocks or voids, which are then removed by a CMP step. The barrier layer may thus subsequently be formed over a defect-free surface, which has already experienced stress release along grain boundaries as a result of the thermal treatment.

Abstract: A green diode laser includes a tubular laser casing, a heat sink sealedly mounted at the laser casing, a semiconductor chip supported by the heat sink, an optical resonant cavity supported within the laser casing, including a lasing medium and an intracavity frequency doubler, an IR blocking filter inclinedly and seadedly mounted at the laser casing to optically communicate with an output facet, and a photodiode supported within the laser casing at a position that when the laser beam exits the output facet, the IR blocking filter reflects a portion of the laser beam towards the photodiode such that the photodiode is adapted for detecting the laser beam from the IR blocking filter as a feedback for controlling a power output of the green laser chip.

Abstract: A green diode laser includes a tubular laser casing, a heat sink sealedly mounted at the laser casing, a semiconductor chip supported by the heat sink, an optical resonant cavity supported within the laser casing, including a lasing medium and an intracavity frequency doubler, an IR blocking filter inclinedly and seadedly mounted at the laser casing to optically communicate with an output facet, and a photodiode supported within the laser casing at a position that when the laser beam exits the output facet, the IR blocking filter reflects a portion of the laser beam towards the photodiode such that the photodiode is adapted for detecting the laser beam from the IR blocking filter as a feedback for controlling a power output of the green laser chip.

Abstract: A method for forming a self-aligned trench is disclosed. The steps of the method include providing a semiconductor substrate with a buried layer. A buffer layer and a first hard mask layer are formed sequentially on a surface of the semiconductor substrate. Parts of the first hard mask layer, the buffer layer and the semiconductor substrate are removed to form openings. A capacitor is formed in the interior of the opening of the semiconductor substrate. A second hard mask layer is formed conformally on the first hard mask layer and the capacitor. An insulator layer and a pattern photoresist layer are formed sequentially on the second hard mask layer.

Abstract: A memory card connector is positioned on a printed circuit board (PCB) which is coupled to ground so as to receive and couple a memory card. The connector has a main body positioned on the PCB. The connector also has a cover removably attached to the main body to define a memory card receiving space between the PCB, the main body and the cover. The cover has at least one flexible extension extending into the receiving space, and a draining portion that is electrically coupled to the main body. The memory card is inserted into the receiving space so that the extension contacts a metal portion on the memory card, with the extension electrically coupled to ground via the draining portion and the main body. Thus, static electricity can be drained to ground via the extension, the draining portion and the main body.

Abstract: A process for preparing a microparticulate complex is provided. The process comprises (a) combining a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible, organic solvent to form a mixture wherein the PFC and the NAC are independently molecularly or micellarly soluble in the aqueous/organic solvent system, and (b) reducing the amount of the organic solvent in the mixture. This effects formation of the microparticulate complex of the NAC and the PFC. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component forming an approximately spherical particle, wherein the particle-forming component encloses an interior of the particle containing the nucleic acid-like component and the so-enclosed interior volume has less than about 50% (preferably less than 20%) of the volume containing free water.