Abstract: The present application provides an anti-CLDN18.2 antibody and an antibody-drug conjugate prepared from the antibody. The antibody or the antibody-drug conjugate can effectively treat CLDN18.2 positive tumors, comprising but not limited to cancers represented by gastric cancer and pancreatic cancer.

Abstract: The present disclosure provides a copper-phosphorus brazing foil and a preparation method thereof, which relates to the technical field of brazing material. It comprises a copper inner core and a copper-phosphorus alloy layer coating outside the copper inner core, wherein the phosphorus content in the copper-phosphorus brazing foil is over 5 wt %, and the thickness of the copper-phosphorus brazing foil is below 0.5 mm. In the present disclosure, red copper foil is used as the core layer, and the surface of the red copper foil is alloyed with a layer of copper-phosphorus alloy by the eutectic reaction between the core layer and red phosphorus, such that the copper-phosphorus brazing foil is obtained. The present disclosure prepares a copper-phosphorus brazing foil with high phosphorus content and lower thickness. Comparing with the traditional preparation method, the preparation method of the present disclosure has high efficiency and high yield.

Abstract: A polyisocyanate composition, a preparation method therefor and an application thereof. The value of the mass content of alkaline hydrolyzed chlorine minus the mass content of water hydrolyzed chlorine in the polyisocyanate composition is 0.1 ppm-100 ppm. The mass content of the alkaline hydrolyzed chlorine is the mass content obtained by calculating halogen dissociated under alkaline conditions and/or halogen dissociated under a temperature condition of 100° C. or more as the relative atomic mass of a chlorine atom.

Abstract: A method for preparing an isocyanate in a gaseous phase by feeding, in the presence or absence of an inert gas, an amine-containing gas stream and a phosgene-containing gas stream into a reaction region, allowing the amine and the phosgene to contact in gaseous forms and undergo a phosgenation reaction in the reaction region, thus preparing the target isocyanate in a gaseous form in the reaction region. The phosgene-containing stream is subjected to preheating and warming before being fed into the reaction region, and the phosgene-containing stream comprises a substance A at a mass fraction of <1% before being subjected to the preheating and warming up. Substance A is a NCO group-containing substance and/or an olefinic double bond-containing substance. The method reduces the formation of clogging matter in a heat exchanger and a vessel during the preheating and warming of the phosgene and during the reaction process.

Abstract: A method for training an artificial neural network so that the artificial neural network identifies a property value among a plurality of property values, each property being able to take at least two different values. The method includes: a primary training including training the neural network to identify at least one target value; and a secondary training for detecting weaknesses of the model trained during the primary training and reinforcing this model by increasing the learning rate of output neurons of the network that are associated with property values most often misestimated.

Abstract: A preparation method of a tetragonal NaV2O5.H2O nanosheet-like powder includes steps of: (Step 1) simultaneously adding NaVO3 and Na2S.9H2O into deionized water, and then magnetically stirring, and obtaining a black turbid solution; (Step 2) sealing after putting the black turbid solution into an inner lining of a reaction kettle, fixing the sealed inner lining in an outer lining of the reaction kettle, placing the reaction kettle into a homogeneous reactor, and then performing a hydrothermal reaction; and (Step 3) after completing the hydrothermal reaction, naturally cooling the reaction kettle to the room temperature, and then alternately cleaning through water and alcohol, and then collecting a product, drying the product, and finally obtaining the tetragonal NaV2O5.H2O nanosheet-like powder with a thickness in a range of 30-60 nm and a single crystal structure grown along a (002) crystal orientation.

Abstract: The present disclosure provides a camera module and an optical lens thereof, an optical lens element and a manufacturing method therefor, and a method for assembling a large wide-angle camera module, wherein the camera module comprises a lens and a photosensitive assembly. The lens comprises a lens barrel, at least one first lens element unit and at least one second lens element unit, and is further provided with at least one notch, wherein the first lens element unit and the second lens element unit are disposed in the lens barrel, and the first lens element unit is configured as a non-rotating body, and wherein the notch is provided in the lens barrel, or the notch is formed in the first lens element unit, or the notch is formed in the second lens element unit, and the first lens element unit is marked by means of the notch.

Abstract: Disclosed is a 1,3-bisisocyanatomethylcyclohexane composition and an optical resin prepared therefrom. The composition comprises, based on the weight of 1,3-bisisocyanatomethylcyclohexane, a) 65%-95 wt % of trans-1,3-bisisocyanatomethylcyclohexane; b) greater than 0 and less than or equal to 0.5 wt %, preferably 0.02-0.5 wt % of 1,4-bisisocyanatomethylcyclohexane. Preferably, the 1,3-bisisocyanatomethylcyclohexane composition contains greater than 0 and less than or equal to 600 ppm of 1-isocyanatomethyl-3-methylcyclohexane, based on the weight of 1,3-bisisocyanatomethylcyclohexane. The 1,3-bisisocyanatomethylcyclohexane composition is used for preparing an optical resin, which can be applied to produce an optical lens with a better performance in preventing opacification and optical distortion.

Abstract: The invention provides a method and a product for manufacturing a titanium alloy dual-structure turbine disk based on partial hydrogenation, which includes the following steps: coating a glass coating on the partial surface of a titanium alloy billet where hydrogen-blocking is required, and sintering the titanium alloy billet coated with the glass coating; performing hydrogenation treatment on the titanium alloy billet, such that the hydrogen concentration at the hydrogenation-required portion reaches the predetermined level; removing the glass coating from the titanium alloy billet; preheating the titanium alloy billet, and then performing high temperature die forging in the forging dies; performing vacuum dehydrogenation treatment on the forged turbine disk to remove hydrogen element inside the forging, so that the hydrogen content is 0.015 wt. % or less.

Abstract: A modified polymer including (a) a main chain containing a fluorine-containing polymer and (b) a side chain represented by the following formula (b1?) and/or a side chain represented by the following formula (b2?). The formula (b1?) is —CH2—CRb1(—X)—C(?O)—Y—Z—Rf, wherein X is a hydrogen atom, a methyl group, or a halogen atom; Y is —O— or —NH—; Z is a direct bond or a divalent organic group; Rf is a C1-C20 fluoroalkyl group; and Rb1 is a hydrogen atom or a monovalent organic group. The formula (b2?) is —CH2—CRb2(—R1)—C(?O)—O—Si(—CH3)2—[O—Si(—CH3)2]n—O—Si(—CH3)2—R2, wherein R1 is a hydrogen atom or a methyl group; R2 is a hydrogen atom or a methyl group; Rb2 is a hydrogen atom or a monovalent organic group; and n is 3 to 200.

Abstract: A drug combination for treatment of amyotrophic lateral sclerosis includes chlorogenic acid, vitamin E, vitamin C, coenzyme Q10, and creatine phosphate sodium, as well as pharmaceutically acceptable carriers, in which chlorogenic acid, vitamin E, vitamin C, coenzyme Q10, and creatine phosphate sodium are unit preparations having same or different specifications, that are simultaneously or separately administrated. The combination of chlorogenic acid, vitamin E, vitamin C, coenzyme Q10, and creatine phosphate sodium shows a synergistic effect on amyotrophic lateral sclerosis, thus provides a combination with excellent therapeutic effect on amyotrophic lateral sclerosis, which delays the progression of amyotrophic lateral sclerosis.

Abstract: Chlorogenic acid is used in the preparation of a medicine for preventing or treating pain. The pain can be cancer pain, skeletal muscle pain and the like. A medicine for preventing or treating pain, the medicine being a pharmaceutical preparation prepared by using chlorogenic acid as an active ingredient and adding pharmaceutically acceptable auxiliary materials. Chlorogenic acid may effectively relieve cancer pain and bone joint pain, and may replace analgesic drugs such as opioids and non-steroidal anti-inflammatory drugs in treatment.

Abstract: The invention involves the pharmaceutical use of honokiol, in particular the use of honokiol in inhibiting medulloblastoma, and it has been experimentally proved that honokiol can inhibit the proliferation and induce cell cycle arrest and apoptosis of medulloblastoma cells; promoting hair growth, and it has been experimentally proved that honokiol can promote hair growth and has no toxic and side effects on liver and kidney; and promoting white hair blackening, and it has been experimentally proved that honokiol can promote white hair blackening and has no toxic side effects on liver and kidney.

Abstract: A method for preparing an isocyanate in a gaseous phase by feeding, in the presence or absence of an inert gas, an amine-containing gas stream and a phosgene-containing gas stream into a reaction region, allowing the amine and the phosgene to contact in gaseous forms and undergo a phosgenation reaction in the reaction region, thus preparing the target isocyanate in a gaseous form in the reaction region. The phosgene-containing stream is subjected to preheating and warming before being fed into the reaction region, and the phosgene-containing stream comprises a substance A at a mass fraction of <1% before being subjected to the preheating and warming up. Substance A is a NCO group-containing substance and/or an olefinic double bond-containing substance. The method reduces the formation of clogging matter in a heat exchanger and a vessel during the preheating and warming of the phosgene and during the reaction process.

Abstract: A method for preparing isophorone diisocyanate by (1) reacting isophorone with hydrogen cyanide in the presence of a catalyst to obtain isophorone nitrile; (2) reacting the isophorone nitrile obtained in step (1) with ammonia gas and hydrogen in the presence of a catalyst to obtain isophorone diamine; and (3) subjecting the isophorone diamine to a phosgenation reaction to obtain the isophorone diisocyanate, wherein the content of impurities containing a secondary amine group in the isophorone diamine that undergoes the phosgenation reaction in step (3) is ?0.5 wt. The method reduces the content of hydrolyzed chlorine in the isophorone diisocyanate product, improves the yellowing resistance of the product, and the harm due to presence of hydrolyzed chlorine in the product is reduced.

Abstract: A drug for use in combination for treating high-grade brain tumors in response to ineffective standard treatment for postoperative recurrence. The drug for includes chlorogenic acid and temozolomide of the same or different unit preparations for simultaneous or separate administration, and a pharmaceutically acceptable carrier. A pharmaceutical composition includes chlorogenic acid and temozolomide can be used to prepare a drug for treatment of high-grade brain tumors for which standard treatment for postoperative recurrence is ineffective.

Abstract: A preparation method of a tetragonal NaV2O5.H2O nanosheet-like powder includes steps of: (Step 1) simultaneously adding NaVO3 and Na2S.9H2O into deionized water, and then magnetically stirring, and obtaining a black turbid solution; (Step 2) sealing after putting the black turbid solution into an inner lining of a reaction kettle, fixing the sealed inner lining in an outer lining of the reaction kettle, placing the reaction kettle into a homogeneous reactor, and then performing a hydrothermal reaction; and (Step 3) after completing the hydrothermal reaction, naturally cooling the reaction kettle to the room temperature, and then alternately cleaning through water and alcohol, and then collecting a product, drying the product, and finally obtaining the tetragonal NaV2O5.H2O nanosheet-like powder with a thickness in a range of 30-60 nm and a single crystal structure grown along a (002) crystal orientation.

Abstract: A drug combination for treatment of amyotrophic lateral sclerosis includes chlorogenic acid, vitamin E, vitamin C, coenzyme Q10, and creatine phosphate sodium, as well as pharmaceutically acceptable carriers, in which chlorogenic acid, vitamin E, vitamin C, coenzyme Q10, and creatine phosphate sodium are unit preparations having same or different specifications, that are simultaneously or separately administrated. The combination of chlorogenic acid, vitamin E, vitamin C, coenzyme Q10, and creatine phosphate sodium shows a synergistic effect on amyotrophic lateral sclerosis, thus provides a combination with excellent therapeutic effect on amyotrophic lateral sclerosis, which delays the progression of amyotrophic lateral sclerosis.

Abstract: A preparation method of a tetragonal NaV2O5.H2O nanosheet-like powder includes steps of: (S1) simultaneously adding NaVO3 and Na2S.9H2O into deionized water, and then magnetically stirring, and obtaining a black turbid solution; (S2) sealing after putting the black turbid solution into an inner lining of a reaction kettle, fixing the sealed inner lining in an outer lining of the reaction kettle, placing the reaction kettle into a homogeneous reactor, and then performing a hydrothermal reaction; and (S3) after completing the hydrothermal reaction, naturally cooling the reaction kettle to the room temperature, and then alternately cleaning through water and alcohol, and then collecting a product, drying the product, and finally obtaining the tetragonal NaV2O5.H2O nanosheet-like powder with a thickness in a range of 30-60 nm and a single crystal structure grown along a (002) crystal orientation.

Abstract: An ink-printed substrate includes a substrate and water-based ink composition printed on the substrate, and has a Crockfastness-Loss-to-Density Ratio of about ?1.0 to about ?6.0.