Abstract: The disclosure provides for pathogenic biomarkers and serum extracellular vesicular biomarkers that are associated with vascular anomalies and malformation of endothelial cells, and uses thereof, including for diagnosis, prognosis and therapy.

Abstract: Described herein are systems and methods for a type of paradigm-shift nanoparticles functionalized endothelial optical exosomes for vascular malformation treatment, including Port Wine Stain, using exosomes as a drug delivery vehicle in combination with Near-Infrared-mediated laser therapy.

Abstract: A method may include obtaining various well logs or various core samples regarding a geological region of interest. The method may further include determining various permeability values, various porosity values, and various dolomite volume fraction values regarding the geological region of interest using the well logs or the core samples. The dolomite volume fraction values may correspond to a percentage of dolomite in a total mineral volume. The method may further include determining, using the porosity values, various permeability thresholds corresponding to various predetermined reservoir qualities. The method may further include generating, using the permeability thresholds, the permeability values, and the dolomite volume fraction values, a reservoir model including various dolomite boundaries defining the predetermined reservoir qualities. The method may further include determining a hydrocarbon trap prediction using the reservoir model.

Abstract: Described herein are methods and systems using ADAM30 as a biomarker to help early diagnosis of congenital malformed vasculatures in children and which can also serve as a companion diagnostic biomarker for malformed vasculatures, as well as a subpopulation of cancer cells, wherein blockage of activity of ADAM30 by a neutralized antibody or inhibitor can be used as a treatment strategy for those ADAM30-positive vascular endothelial cells and cancer cells.

Abstract: Described herein are biomarkers that have shown significantly increased expression levels in malformed blood vessels as compared to normal vessels, as well as methods of use employing the novel biomarkers to provide early diagnosis of congenital vascular malformations as well as treatment for same.

Abstract: Methods for dolomite mapping using multiscale fracture characterization include using a computer system to receive seismic data for a geographical area. The computer system identifies one or more macroscale fractures located within the geographical area based on a three-dimensional (3D) visualization of the seismic data. The computer system identifies one or more mesoscale fractures located within the geographical area based on a curvature map generated from the seismic data. The computer system identifies one or more microscale fractures located within the geographical area based on an amount of chaotic seismic reflections indicated by the seismic data. The computer system identifies a dolomite distribution of the geographical area based on the one or more macroscale fractures, the one or more mesoscale fractures, and the one or more microscale fractures. A display device of the computer system generates a graphical representation of the dolomite distribution.

Abstract: A method may include obtaining various well logs or various core samples regarding a geological region of interest. The method may further include determining various permeability values, various porosity values, and various dolomite volume fraction values regarding the geological region of interest using the well logs or the core samples. The dolomite volume fraction values may correspond to a percentage of dolomite in a total mineral volume. The method may further include determining, using the porosity values, various permeability thresholds corresponding to various predetermined reservoir qualities. The method may further include generating, using the permeability thresholds, the permeability values, and the dolomite volume fraction values, a reservoir model including various dolomite boundaries defining the predetermined reservoir qualities. The method may further include determining a hydrocarbon trap prediction using the reservoir model.

Abstract: Methods for dolomite mapping using multiscale fracture characterization include using a computer system to receive seismic data for a geographical area. The computer system identifies one or more macroscale fractures located within the geographical area based on a three-dimensional (3D) visualization of the seismic data. The computer system identifies one or more mesoscale fractures located within the geographical area based on a curvature map generated from the seismic data. The computer system identifies one or more microscale fractures located within the geographical area based on an amount of chaotic seismic reflections indicated by the seismic data. The computer system identifies a dolomite distribution of the geographical area based on the one or more macroscale fractures, the one or more mesoscale fractures, and the one or more microscale fractures. A display device of the computer system generates a graphical representation of the dolomite distribution.

Abstract: The disclosure provides for pathogenic biomarkers and serum extracellular vesicular biomarkers that are associated with vascular anomalies and malformation of endothelial cells, and uses thereof, including for diagnosis, prognosis and therapy.