Abstract: This disclosure provides CRISPR/Cas9 based fusion molecules and guide RNAs for use in in vivo targeted reduction or elimination of VEGFA gene products. This disclosure also relates to formulations, methods of production and methods of use thereof.

Abstract: This disclosure provides CRISPR/Cas9 based fusion molecules and guide RNAs for use in in vivo targeted reduction or elimination of PCSK9 gene products. This disclosure also relates to formulations, methods of production and methods of use thereof.

Abstract: The present application provides a semiconductor device and a manufacturing method thereof and a memory system. The manufacturing method of the semiconductor device includes: forming a dielectric layer on a stack layer, wherein memory channel structures penetrating through the stack layer along a first direction are disposed in the stack layer, and the first direction is parallel to a stacking direction of the stack layer; forming a plurality of openings penetrating through the dielectric layer along the first direction, with the rest of the dielectric layer forming top selective gate cut lines, wherein the plurality of openings are arranged as being spaced apart along a second direction, one of the top selective gate cut lines is located between two adjacent ones of the openings in the second direction, and the first direction intersects the second direction; and forming a top selective gate layer in the plurality of openings.

Abstract: A method for prognostic survival stage prediction based on machine learning includes acquiring patients' original information data within a previous preset time period and integrating the patients' original information data so as to obtain a first data set without recurrence time and a second data set with recurrence time; performing analysis based on preoperative information, postoperative information and survival status of each corresponding patient, so as to obtain a correlation degree among the preoperative information, the postoperative information and the survival status; and training in the first data set, so as to obtain a postoperative survival probability prediction model. The method includes training in the second data set, so as to obtain a survival time period prediction model if judging that a survival probability of a target patient is less than or equal to a preset value according to the postoperative survival probability prediction model.

Abstract: A method for installing a maximum power point tracking (MPPT) controller is provided. The method includes acquiring an occlusion area proportion of a photovoltaic string in a photovoltaic system, optimizing the occlusion area proportion to generate a target occlusion area proportion, determining a target position from the photovoltaic string according to the target occlusion area proportion, and installing the MPPT controller at the target position.

Abstract: The photovoltaic cell sheet includes: a cell sheet body having a first end and a second end opposite to each other in a width direction of the cell sheet body, wherein the first end of the cell sheet body is provided with a plurality of sawtooth spacing along a length direction of the cell sheet body; a first main gate arranged at one side of front and back sides of the plurality of sawtooth and serving as a first electrode; and a second main gate arranged at another side of the front and back sides of the cell sheet body and serving as a second electrode, wherein the second main gate is adjacent to the second end of the cell sheet body.

Abstract: A method for installing a maximum power point tracking (MPPT) controller is provided. The method includes acquiring an occlusion area proportion of a photovoltaic string in a photovoltaic system, optimizing the occlusion area proportion to generate a target occlusion area proportion, determining a target position from the photovoltaic string according to the target occlusion area proportion, and installing the MPPT controller at the target position.

Abstract: The invention discloses an ultra-long tunnel sewage disposal, separation and drainage structure suitable for cold regions, comprising: a tunnel portal section drainage structure and a tunnel body section drainage structure and an out-tunnel clear water ditch, an out-tunnel deep-buried ditch, an out-tunnel sewage ditch and a clear water tank; the tunnel portal section drainage structure comprises a central ditch and a side sewage ditch A, the central ditch is deeply buried in the position, lower than the freezing depth, of a tunnel portal section of the main tunnel, and the side sewage ditches A are arranged on both sides of the tunnel portal section of the main tunnel; the tunnel body section drainage structure comprises a side clear water ditch and a side sewage ditch B, and the side clear water ditch and the side sewage ditch B are arranged on both sides of the tunnel body section of the main tunnel.

Abstract: The invention discloses an ultra-long tunnel sewage disposal, separation and drainage structure suitable for cold regions, comprising: a tunnel portal section drainage structure and a tunnel body section drainage structure and an out-tunnel clear water ditch, an out-tunnel deep-buried ditch, an out-tunnel sewage ditch and a clear water tank; the tunnel portal section drainage structure comprises a central ditch and a side sewage ditch A, the central ditch is deeply buried in the position, lower than the freezing depth, of a tunnel portal section of the main tunnel, and the side sewage ditches A are arranged on both sides of the tunnel portal section of the main tunnel; the tunnel body section drainage structure comprises a side clear water ditch and a side sewage ditch B, and the side clear water ditch and the side sewage ditch B are arranged on both sides of the tunnel body section of the main tunnel.

Abstract: A test system and method for thermoelectric module. The test system includes an electrical performance test unit, a heat flux detection unit, and a processor. The electrical performance test unit connects with the thermoelectric module under power generation state to test output power of the thermoelectric module and working current and internal resistance under this output power. The heat flux detection unit includes a heat flux sensor installed at a cold-end of the thermoelectric module to detect the heat flux. The processor electrically connects with the electrical performance test unit and the heat flux detection unit to calculate the thermoelectric conversion efficiency ? of thermoelectric module. By using the technical scheme of the invention, the detection of the thermoelectric conversion efficiency of the thermoelectric module is accomplished.

Abstract: A test system and method for thermoelectric module. The test system includes an electrical performance test unit, a heat flux detection unit, and a processor. The electrical performance test unit connects with the thermoelectric module under power generation state to test output power of the thermoelectric module and working current and internal resistance under this output power. The heat flux detection unit includes a heat flux sensor installed at a cold-end of the thermoelectric module to detect the heat flux. The processor electrically connects with the electrical performance test unit and the heat flux detection unit to calculate the thermoelectric conversion efficiency ? of thermoelectric module. By using the technical scheme of the invention, the detection of the thermoelectric conversion efficiency of the thermoelectric module is accomplished.