Abstract: The invention provides methods for preparing a preparation of amplified DNA derived from a biological sample of a pregnant woman useful for identifying neoplasm in a pregnant woman, comprising: (a) isolating cell-free DNA from a biological sample of a pregnant woman comprising a mixture of fetal cell-free DNA and maternal cell-free DNA; (b) preparing a preparation of amplified DNA by performing targeted multiplex amplification on the isolated cell-free DNA to amplify at least 100 polymorphic loci; (c) analyzing the preparation of amplified DNA by sequencing the amplified DNA to obtain sequence reads of the at least 100 polymorphic loci and using the sequence reads to identify copy number variations (CNVs) in fetal and maternal chromosomes or chromosomal segments of interest, and identifying neoplasm in the pregnant woman by the presence of two or more of CNVs in the maternal chromosomes or chromosomal segments of interest.

Abstract: The present disclosure provides for a coated flexible open-cell polyurethane foam structure. The coated flexible open-cell polyurethane foam structure includes a flexible open-cell polyurethane foam having a first major surface and a second major surface opposite the first major surface. The coated flexible open-cell polyurethane foam structure further includes a flexible heat conductive material covering 30 to 90 percent (cov., expressed in %) of a surface area of the first major surface of the flexible open-cell polyurethane foam in a predefined shape to provide one or more gaps exposing the flexible open-cell polyurethane foam between defined edges of the flexible heat conductive material, where each gap of the one or more gaps has a gap width according to Formula I: gap width (mm)??0.196×cov. (%)+20.6 (Formula I) where a total surface area of the one or more gaps provides 70 to 10 percent of the surface area of the first major surface of the flexible open-cell polyurethane foam.

Abstract: The present disclosure is directed to a dosing cap (10). In an embodiment, the dosing cap (10) includes (A) a collar member (12). The collar member (12) has an annular skirt (18) depending from a base (16)(B). An inner surface of the skirt has a securing member for securing the collar member to a neck (21) of a container (20). The base (B) has (i) a top surface (30) and a bottom surface (32), (ii) a valve seat (34) is present on the top surface of the base. The valve seat has a center channel (36), and a radial channel (38), the channels extend through the base. The dosing cap includes (C) a plug member (40). The plug member is composed of a polymeric material. The plug member has the following components in inter-connected relationship: a head (42), a body (44), a leg (46), an ankle (48), and a flexible foot (50). The leg extends through the center channel, such that the head opposes the valve seat on the top surface of the base and the foot opposes the bottom surface of the base.

Abstract: The present disclosure provides a dosing cap. In an embodiment, the dosing cap includes (A) a collar member having an annular skirt depending from a base. An inner surface of the annular skirt has a securing member for securing the collar member to a neck of a container. The base includes (i) at least one opening with a one-way valve permitting fluid flow in a first direction, and (ii) an air channel with a one-way valve permitting fluid flow in a second direction. The dosing cap includes (B) a cap member having an annular sidewall extending from a dispensing element. An inner surface of the annular sidewall has an attachment member adjustably attached to a reciprocal attachment member on an outer surface of the first sidewall. The dosing cap includes (C) a metering chamber formed by an enclosed volume between the cap member and the base. The dosing cap includes (D) the dispensing element permitting flow of a fluid from the metering chamber.

Abstract: The present disclosure is directed to a dosing cap (10). In an embodiment, the dosing cap (10) includes (A) a collar member (12). The collar member (12) has an annular skirt (18) depending from a base (16)(B). An inner surface of the skirt has a securing member for securing the collar member to a neck (21) of a container (20). The base (B) has (i) a top surface (30) and a bottom surface (32), (ii) a valve seat (34) is present on the top surface of the base. The valve seat has a center channel (36), and a radial channel (38), the channels extend through the base. The dosing cap includes (C) a plug member (40). The plug member is composed of a polymeric material. The plug member has the following components in inter-connected relationship: a head (42), a body (44), a leg (46), an ankle (48), and a flexible foot (50). The leg extends through the center channel, such that the head opposes the valve seat on the top surface of the base and the foot opposes the bottom surface of the base.

Abstract: A mixing device for a magnetic bead reagent includes a magnetic member, a container storage mechanism, and a drive mechanism. The container storage mechanism includes a mounting part for mounting a magnetic bead liquid container storing a magnetic bead reagent, and the mounting part corresponds to the magnetic member, enabling the container on the mounting part to be located within the magnetic field. The drive mechanism has a drive structure capable of driving at least one of the magnetic member, the mounting part, and the container to move, and thus generating a relative movement between the container and the magnetic field. The direction of the magnetic force acting on the magnetic beads is changed by the relative movement between the magnetic bead reagent and the magnetic field, such that the magnetic beads flow along different directions under the magnetic force, thereby increasing mixing efficiency of magnetic bead reagent.

Abstract: The present disclosure provides a dosing cap. In an embodiment, the dosing cap includes (A) a collar member having an annular skirt depending from a base. An inner surface of the annular skirt has a securing member for securing the collar member to a neck of a container. The base includes (i) at least one opening with a one-way valve permitting fluid flow in a first direction, and (ii) an air channel with a one-way valve permitting fluid flow in a second direction. The dosing cap includes (B) a cap member having an annular sidewall extending from a dispensing element. An inner surface of the annular sidewall has an attachment member adjustably attached to a reciprocal attachment member on an outer surface of the first sidewall. The dosing cap includes (C) a metering chamber formed by an enclosed volume between the cap member and the base. The dosing cap includes (D) the dispensing element permitting flow of a fluid from the metering chamber.

Abstract: The present disclosure provides for a coated flexible open-cell polyurethane foam structure. The coated flexible open-cell polyurethane foam structure includes a flexible open-cell polyurethane foam having a first major surface and a second major surface opposite the first major surface. The coated flexible open-cell polyurethane foam structure further includes a flexible heat conductive material covering 30 to 90 percent (cov., expressed in %) of a surface area of the first major surface of the flexible open-cell polyurethane foam in a predefined shape to provide one or more gaps exposing the flexible open-cell polyurethane foam between defined edges of the flexible heat conductive material, where each gap of the one or more gaps has a gap width according to Formula I: gap width (mm) ??0.196×cov. (%)+20.6 (Formula I) where a total surface area of the one or more gaps provides 70 to 10 percent of the surface area of the first major surface of the flexible open-cell polyurethane foam.

Abstract: A shearer cutting unit with double-speed rollers includes a motor driving unit, a motor driving unit, a gear transmission unit and a roller output unit. The motor driving unit includes a left cutting motor and a right cutting motor which are both arranged in a cutting unit case and connected with the roller output unit in a transmission way through the gear transmission unit. The roller output unit comprises a middle output shaft (3-1), a far-end output shaft, a middle support frame, a middle roller, a far-end support frame and a far-end roller. A cutting roller is separated into two coaxially-rotating parts, and the two rollers can rotate in different speeds.

Abstract: A shearer cutting unit with double-speed rollers includes a motor driving unit, a motor driving unit, a gear transmission unit and a roller output unit. The motor driving unit includes a left cutting motor and a right cutting motor which are both arranged in a cutting unit case and connected with the roller output unit in a transmission way through the gear transmission unit. The roller output unit comprises a middle output shaft (3-1), a far-end output shaft, a middle support frame, a middle roller, a far-end support frame and a far-end roller. A cutting roller is separated into two coaxially-rotating parts, and the two rollers can rotate in different speeds.

Abstract: An apparatus includes a phase interpolator configured to receive a four-phase signal and output a six-phase signal, and a summing network configured to receive the six-phase signal and output a two-phase signal, wherein: a first phase, a third phase, and a fifth phase of the six-phase signal are summed to generate a second phase of the two-phase signal, while a second phase, a fourth phase, and a sixth phase of the six-phase signal are summed to generate a first phase of the two-phase signal.

Abstract: A user equipment is operative to receive prioritization information for a plurality of unlicensed carriers from a cellular network node and to use the prioritization information for channel measurements or carrier selection.

Abstract: A user equipment is operative to receive prioritization information for a plurality of unlicensed carriers from a cellular network node and to use the prioritization information for channel measurements or carrier selection.