Patents by Inventor Wenceslao Lumeras Amador

Wenceslao Lumeras Amador has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KRAS INHIBITORS
    Publication number: 20240043451
    Abstract: The present invention provides compounds of the formula: wherein A, B, D1, X, Y, Z, G, R1, R2, and R3a are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.
    Type: Application
    Filed: March 24, 2023
    Publication date: February 8, 2024
    Inventors: David Anthony BARDA, Jolie Anne BASTIAN, Kelly Wayne FURNESS, Deqi GUO, James Robert HENRY, Richard Duane JOHNSTON, Jason Eric LAMAR, Tao LIU, Michael John RODRIGUEZ, Almudena RUBIO, Chong SI, Gaiying ZHAO, Mohammad Sadegh ZIA-EBRAHIMI, Matthew Patrick BAUMGARTNER, Isabel ROJO, Mario BARBERIS, Santiago CARBALLARES MARTIN, Pablo GARCIA LOSADA, Sonia Maria GUTIERREZ SANFELICIANO, Wenceslao LUMERAS AMADOR, Victoriano MOLERO FLOREZ, Maria Lourdes PRIETO VALLEJO
  • COMPOUNDS USEFUL FOR INHIBITING CDK7
    Publication number: 20230203031
    Abstract: CDK7 inhibitors according to the formula (I): wherein X is —CH(OH)CH3, —CHFCH3, —CF2CH3, or —CF3; Y is —CH?CH2 or C2H?C2H2; and Z is CH(CH3)2 or C2H(CH3)(CH22H), pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use are provided.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 29, 2023
    Inventors: Maria Carmen FERNANDEZ FIGUEROA, Wenceslao LUMERAS AMADOR, Concepcion SANCHEZ-MARTINEZ
  • 7,8-DIHYDRO-4H-PYRAZOLO[4,3-c]AZEPINE-6-ONE COMPOUNDS
    Publication number: 20220251096
    Abstract: Disclosed herein are compounds of Formula I: wherein R1 is CH3 or CH2CH3; and pharmaceutically acceptable salts thereof, which are useful for treating cancer.
    Type: Application
    Filed: August 3, 2020
    Publication date: August 11, 2022
    Inventors: Wenceslao LUMERAS AMADOR, Barbara Jean BRANDHUBER
  • Mutant IDH1 inhibitors
    Patent number: 10696665
    Abstract: The present application provides compounds of Formula I: Formula (I) that are useful as inhibitors of mutant IDH1, pharmaceutical compositions, and uses for the treatment of cancer.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: June 30, 2020
    Assignee: Eli Lilly and Company
    Inventors: Wenceslao Lumeras Amador, Serge Louis Boulet, Timothy Paul Burkholder, Santiago Carballares Martin, Raymond Gilmour, Patric James Hahn, Renato Alejandro Bauer, Zoran Rankovic
  • MUTANT IDH1 INHIBITORS
    Publication number: 20190292175
    Abstract: The present application provides compounds of Formula I: Formula (I) that are useful as inhibitors of mutant IDH1, pharmaceutical compositions, and uses for the treatment of cancer.
    Type: Application
    Filed: May 30, 2017
    Publication date: September 26, 2019
    Inventors: Wenceslao LUMERAS AMADOR, Serge Louis BOULET, Timothy Paul BURKHOLDER, Santiago CARBALLARES MARTIN, Raymond GILMOUR, Patric James HAHN, Renato Alejandro BAUER, Zoran RANKOVIC
  • Cyclohexylamine derivatives having ?2 adrenergic antagonist and M3 muscarinic antagonist activities
    Patent number: 9643961
    Abstract: The present invention relates to novel compounds having ?2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: May 9, 2017
    Assignee: Almirall, S.A.
    Inventors: Maria Prat Quinones, Silvia Fonquerna Pou, Carlos Puig Duran, Wenceslao Lumeras Amador, Jose Aiguade Bosch, Juan Francisco Caturla Javaloyes
  • NEW CYCLOHEXYLAMINE DERIVATIVES HAVING ß2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES
    Publication number: 20160264557
    Abstract: The present invention relates to novel compounds having ?2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
    Type: Application
    Filed: March 14, 2016
    Publication date: September 15, 2016
    Inventors: Maria PRAT QUINONES, Silvia FONQUERNA POU, Carlos PUIG DURAN, Wenceslao LUMERAS AMADOR, Jose AIGUADE BOSCH, Juan Francisco CATURLA JAVALOYES
  • Cyclohexylamine derivatives having ?2 adrenergic agonist and M3 muscarinic antagonist activities
    Patent number: 9315463
    Abstract: The present disclosure relates to novel compounds having ?2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: April 19, 2016
    Assignee: Almirall, S.A.
    Inventors: Maria Prat Quinones, Silvia Fonquerna Pou, Carlos Puig Duran, Wenceslao Lumeras Amador, Jose Aiguade Bosch, Juan Francisco Caturla Jovaloyes
  • NEW CYCLOHEXYLAMINE DERIVATIVES HAVING ß2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES
    Publication number: 20130281415
    Abstract: The present disclosure relates to novel compounds having ?2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
    Type: Application
    Filed: May 13, 2011
    Publication date: October 24, 2013
    Inventors: Maria Prat Quinones, Silvia Fonquerna Pou, Carlos Puig Duran, Wenceslao Lumeras Amador, Jose Aiguade Bosch, Juan Francisco Caturla Javaloyes
  • NEW CYCLOHEXYLAMINE DERIVATIVES HAVING beta2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES
    Publication number: 20130053359
    Abstract: The present disclosure relates to novel compounds having ?2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
    Type: Application
    Filed: May 13, 2011
    Publication date: February 28, 2013
    Inventors: Maria Prat Quinones, Silvia Fonquerna Pou, Carlos Puig Duran, Wenceslao Lumeras Amador, Jose Aiguade Bosch, Juan Francisco Caturla Jovaloyes
  • 4,8-diphenyl-polyazanaphthalene derivatives
    Patent number: 8334294
    Abstract: New inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) are disclosed herein, as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: December 18, 2012
    Assignee: Almirall, S.A.
    Inventors: Wenceslao Lumeras Amador, Paul Robert Eastwood
  • New Pyridin-3-Amine Derivatives
    Publication number: 20110098298
    Abstract: This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.
    Type: Application
    Filed: February 12, 2007
    Publication date: April 28, 2011
    Inventors: Bernat Vidal Juan, Juan Francisco Caturla Javaloyes, Wenceslao Lumeras Amador, Laura Vidal Gispert
  • 1,7-naphthyridine derivatives as p38 MAP kinase inhibitors
    Patent number: 7906530
    Abstract: New inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) are disclosed, as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: March 15, 2011
    Assignee: Laboratorios Almirall, S.A.
    Inventors: Juan Francisco Caturla Javaloyes, Laura Vidal Gispert, Wenceslao Lumeras Amador
  • 1,7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS
    Publication number: 20100227881
    Abstract: New inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) are disclosed, as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy.
    Type: Application
    Filed: August 7, 2007
    Publication date: September 9, 2010
    Inventors: Juan Francisco Caturla Javaloyes, Laura Vidal Gispert, Wenceslao Lumeras AMADOR
  • NEW 4,8-DIPHENYL-POLYAZANAPHTHALENE DERIVATIVES
    Publication number: 20100130517
    Abstract: New inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) are disclosed herein, as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy.
    Type: Application
    Filed: April 25, 2008
    Publication date: May 27, 2010
    Inventors: Wenceslao Lumeras Amador, Paul Robert Eastwood
  • Pyridazin-3(2H)-one derivatives and their use as PDE4 inhibitors
    Patent number: 7511038
    Abstract: New pyridazin-e-(2H)-one derivatives having the chemical structure of general formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of phosphodiesterase 4.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: March 31, 2009
    Assignee: Laboratorios Almirall S.A.
    Inventors: Vittorio Dal Piaz, Nuria Aguilar Izquierdo, Maria Antonia Buil Albero, Yolanda Garrido Rubio, Maria Paola Giovannoni, Jordi Gracia Ferrer, Wenceslao Lumeras Amador, Claudia Vergelli
  • Pyridazin-3(2H)-One Derivatives And Their Use As Pde4 Inhibitors
    Publication number: 20090029996
    Abstract: The invention relates to new therapeutically useful pyridazin-3(2H)-one derivatives, to processes for their preparation and to pharmaceutical compositions containing them. These compounds are potent and selective inhibitors of phosphodiesterase 4 (PDE4) and are thus useful in the treatment, prevention and suppression of related pathological conditions, diseases and disorders, in particular asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, topic dermatitis, psoriasis or irritable bowel disease.
    Type: Application
    Filed: June 21, 2005
    Publication date: January 29, 2009
    Inventors: Nuria Aguilar Izquierdo, Marta Carrascal Riera, Vittorio Dal Piaz, Jordi Gracia Ferrer, Wenceslao Lumeras Amador, Maria Del Carmen Masdeu Margalef, Graham Warrellow
  • Pyridazin-3(2)-one derivatives and their use as pde4 inhibitors
    Publication number: 20070197536
    Abstract: New pyridazin-e-(2H)-one derivatives having the chemical structure of general formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of phosphodiesterase 4.
    Type: Application
    Filed: November 8, 2004
    Publication date: August 23, 2007
    Inventors: Vittorio Dal Piaz, Nuria Aguilar Izquierdo, Maria Buil Albero, Yolanda Garrido Rubio, Maria Giovannoni, Jordi Gracia Ferrer, Wenceslao Lumeras Amador, Claudia Vergelli