Abstract: Compositions of engineered extracellular vesicles for delivery of cargo to targeted tissues and cells are described herein. Also described herein are methods for making and using the extracellular vesicles described herein. Lastly, described herein are methods for treating a subject, the method comprising administering to a subject an extracellular vesicle as described herein.

Abstract: Compositions and methods for modified viral vectors which mitigate the immunogenicity of viral vectors, enabling multiple administrations of viral-based gene delivery viral vectors are described herein. The viral vectors advantageously possess low immunogenicity and comprise at least one immunosuppressive moiety. Also described herein are methods for introducing genetic material into a cell. Additionally, described herein are methods for preparing a modified viral vector. Lastly, described herein are methods for treating a subject, the method comprising administering to a subject a modified viral vector composition as described above.