Abstract: The present application relates to the use of an antibody-drug conjugate, and a combined drug and the use thereof. Specifically provided are the use of an antibody-drug conjugate, a combined drug and the use thereof. The antibody-drug conjugate shows a significant pharmacodynamic effect of inhibiting tumor cell growth in various NSCLC cell lines with EGFR mutation expression and various human NSCLC PDX tumor models of AZD9291 drug resistance with EGFR mutation expression. In addition, the combined administration of the antibody-drug conjugate and an anti-PD-1 antibody or an anti-PD-L1 antibody shows a significant synergistic pharmacodynamic effect of inhibiting tumor cell growth in the human NSCLC PDX tumor model of AZD9291 drug resistance with EGFR mutation expression.

Abstract: This document provides methods and materials for treating a mammal having HER2-expressing cancers. For example, antibody drug conjugates containing an anti-HER2 antibody and at least one molecule of an anti-cancer drug are provided, as well as methods of administering such antibody drug conjugates to a mammal (e.g., a human) having a HER2-expressing cancer to treat the mammal.

Abstract: A buoyancy-type pillow with a combined action of gas and liquid media is provided. The pillow includes a first pillow body, a second pillow body stacked on a top of the first pillow body, and an interlayer support pad located in an inner cavity of the second bladder. The first pillow body includes a first bladder having a flat shape, the inner cavity of the first bladder is filled with gas medium, and the first bladder is provided with a gas volume adjustment interface. The second pillow body includes a second bladder having a flat shape, the inner cavity of the second bladder is filled with liquid medium, and the second bladder is provided with a liquid volume adjustment interface. The interlayer support pad has a porous structure that allows the liquid medium to flow through. The disclosure achieves an all-around buoyancy support effect.

Abstract: This document provides methods and materials for treating a mammal having HER2-expressing cancers. For example, antibody drug conjugates containing an anti-HER2 antibody and at least one molecule of an anti-cancer drug are provided, as well as methods of administering such antibody drug conjugates to a mammal (e.g., a human) having a HER2-expressing cancer to treat the mammal.

Abstract: A back-following support device, a control method for preventing sedentariness, and a chair are provided. The back-following support device including: a backrest plate; a flexible back and waist support, including a cushion airbag disposed over the backrest plate; and a control system, including a controller, an air supply device for inflating the cushion airbag, a pressure-regulating valve for controlling the amount of air in the cushion airbag, and an air pressure sensor for detecting air pressure inside the cushion airbag; the air supply device, the pressure-regulating valve, and the air pressure sensor are all connected to the controller. The seat and the back-following support device can be adjusted to make the chair more comfortable, thereby effectively supporting the user's waist and/or back and meeting requirements of different people.

Abstract: Disclosed are a sleeve grouting device and method for prefabricated building, relating to the technical field of engineering construction. The grouting device includes a sleeve, a driver and an oscilloscope, sleeve openings at two ends of the sleeve each are configured to be penetrated by connection rebars of each of two different prefabricated components, a piezoelectric ceramic is provided horizontally at each of the sleeve openings at two ends of the sleeve, a corresponding one of the piezoelectric ceramics is electrically connected to the driver and another corresponding one of the piezoelectric ceramics is electrically connected to the oscilloscope; a bottom end of the sleeve is connected to an inlet pipe to be communicated with a g grout injection equipment, and a top end of the sleeve is connected to an outlet pipe.

Abstract: Disclosed are a prefabricated energy pile, a construction method and a heat pump heat exchange system. The energy pile includes a pile body and a heat exchange pipeline. The pile body includes a stainless steel pipe, a metal lining pipe extending within the stainless steel pipe and a concrete pipe between the metal lining pipe and the stainless steel pipe. A heat conductor between the stainless steel pipe and the metal lining pipe is in contact connection with the stainless steel pipe and the metal lining pipe. The heat exchange pipeline includes a first pipe section and a second pipe section in communication with each other, through which a heat exchange medium flows in turn. Tops of the first pipe section and the second pipe section protrude upward out of the energy pile. The second pipe section is in contact connection with the metal lining pipe.

Abstract: Disclosed are a sleeve grouting device and method for prefabricated building, relating to the technical field of engineering construction. The grouting device includes a sleeve, a driver and an oscilloscope, sleeve openings at two ends of the sleeve each are configured to be penetrated by connection rebars of each of two different prefabricated components, a piezoelectric ceramic is provided horizontally at each of the sleeve openings at two ends of the sleeve, a corresponding one of the piezoelectric ceramics is electrically connected to the driver and another corresponding one of the piezoelectric ceramics is electrically connected to the oscilloscope; a bottom end of the sleeve is connected to an inlet pipe to be communicated with a g grout injection equipment, and a top end of the sleeve is connected to an outlet pipe.

Abstract: Disclosed are a prefabricated energy pile, a construction method and a heat pump heat exchange system. The energy pile includes a pile body and a heat exchange pipeline. The pile body includes a stainless steel pipe, a metal lining pipe extending within the stainless steel pipe and a concrete pipe between the metal lining pipe and the stainless steel pipe. A heat conductor between the stainless steel pipe and the metal lining pipe is in contact connection with the stainless steel pipe and the metal lining pipe. The heat exchange pipeline includes a first pipe section and a second pipe section in communication with each other, through which a heat exchange medium flows in turn. Tops of the first pipe section and the second pipe section protrude upward out of the energy pile. The second pipe section is in contact connection with the metal lining pipe.

Abstract: A smart mattress, including a mattress body (1), and further including an airbag assembly (2) disposed on a supporting surface of the mattress body (1). The airbag assembly (2) includes multiple airbags respectively used to support multiple parts of the human body, the height of each of the airbags is adjustable. The present smart mattress has a sleep aid function; the air volumes of corresponding airbags in the airbag assembly (2) can be controlled according to a user's experience, so that the heights of the corresponding airbags are flexibly adjusted to achieve the purpose of floating support of different parts of the human body, and the supporting heights of parts of the mattress are alternately and gently changed to achieve the function of relaxing and massage before sleeping. The smart mattress further has a wake-up function and portability; the mattress body (1) can be folded for carrying with one.

Abstract: Provided are an anti-CD20 antibody-drug conjugate, a preparation comprising the antibody-drug conjugate, a composition comprising the antibody-drug conjugate, and a pharmaceutical use of the antibody-drug conjugate.

Abstract: A method for identifying a medium structure coupling and a fracture network morphology of a shale gas reservoir includes the following steps. Firstly, performing a fracturing test on shale cores by using a modified Brazilian disc test and categorizing the fracture network morphology. Secondly, performing a shale matrix-fracture structure and stress sensitivity test on the shale cores having different fracture network morphology. After that, determining a stress sensitivity constant of different fracture network morphology according to indoor core data and finally preparing an identification chart of the fracture network morphology based on an indoor core stress sensitivity test combined with a production practice. The identification chart can be applied to an actual fracturing well, and the fracture network morphology is directly identified by a real-time effective stress and a normalized flow.

Abstract: A method for removing precursors in recombinant human nerve growth factor (rhNGF) by hydrophobic interaction chromatography (HIC) is provided, where a Chinese hamster ovary (CHO) cell culture is processed by column chromatography for preliminary purification, and the pretreated sample obtained therefrom is further processed in a HIC column by washing the sample and then eluting the HIC column.

Abstract: An efficient and high-quality preparation method of lyophilized vegetable noodles is disclosed, which uses high gluten wheat flour and vegetable powder as major raw materials, adds modified starch, edible salt, an emulsifier, edible colloid, a water retaining agent, edible oil, a flavoring agent, a colorant, maltodextrin and wheat gluten, and conducts rising, dough pressing, cooking, high temperature steam gelatinization, rinsing, ultrasonic treatment and infrared lyophilization to obtain convenient and instant lyophilized vegetable noodles. The lyophilized noodles processed by adopting the method have moisture content of 5%-8%, shortened drying time by more than 10 h than ordinary lyophilization, merit factor of more than 90%, easy brewing, smooth and pliable taste, strong aroma, yellowish color, long shelf life and low production power consumption.

Abstract: This document provides methods and materials for treating a mammal having HER2-expressing cancers. For example, antibody drug conjugates containing an anti-HER2 antibody and at least one molecule of an anti-cancer drug are provided, as well as methods of administering such antibody drug conjugates to a mammal (e.g., a human) having a HER2-expressing cancer to treat the mammal.

Abstract: A method for preparing purified recombinant human nerve growth factor (rhNGF) is provided. In the method, hydrophobic interaction chromatography (HIC) and cation-exchange chromatography (CEC) operations are sequentially performed on a Chinese hamster ovary (CHO) cell culture. The method allows for removal of rhNGF precursors, N-terminal truncated variants, and other variants of rhNGF from the CHO cell culture to thereby obtain a purified rhNGF product.

Abstract: A method for identifying a medium structure coupling and a fracture network morphology of a shale gas reservoir includes the following steps. Firstly, performing a fracturing test on shale cores by using a modified Brazilian disc test and categorizing the fracture network morphology. Secondly, performing a shale matrix-fracture structure and stress sensitivity test on the shale cores having different fracture network morphology. After that, determining a stress sensitivity constant of different fracture network morphology according to indoor core data and finally preparing an identification chart of the fracture network morphology based on an indoor core stress sensitivity text combined with a production practice. The identification chart can be applied to an actual fracturing well, and the fracture network morphology is directly identified by a real-time effective stress and a normalized flow.

Abstract: A method for removing an N-terminal truncated variant and an abnormal variant in recombinant human nerve growth factor (rhNGF) is provided. An rhNGF raw material loaded on a cation-exchange material is washed with a washing liquid to obtain a washed raw material from which an N-terminal truncated variant and an abnormal variant have been removed, where the washing liquid has higher electrical conductivity than the rhNGF raw material. Cation-exchange chromatography (CEC) elution is then performed on the washed raw material with an elution buffer having higher electrical conductivity than the washing liquid. A purified rhNGF product is obtained from the eluate.

Abstract: A method for removing precursors in recombinant human nerve growth factor (rhNGF) by hydrophobic interaction chromatography (HIC) is provided, where a Chinese hamster ovary (CHO) cell culture is processed by column chromatography for preliminary purification, and the pretreated sample obtained therefrom is further processed in a HIC column by washing the sample and then eluting the HIC column.

Abstract: A device and a method for evaluating a gas-water two-phase flow fracture conductivity of a fractured shale. The device includes a seepage system, an injection system, a data collecting and processing system and a three-axis shale core holder, wherein the seepage system is subjected to two stages including a water injection stage and a gas flooding stage. When using the device, firstly the initial permeability and initial mass of the shale sample are determined; the water influx test is performed by injecting water to the shale sample until flow rate of the water discharged from the shale core is stable, then the water injection is ended. After the drying device is installed, the shale sample is subjected to gas flooding, and the aqueous fracturing fluid discharged by the gas flooding is collected until the flow meter determines that the gas volume is stable, and then the gas flooding is ended.