Patents by Inventor Wendel W. Doubleday

Wendel W. Doubleday has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for synthesizing substituted isoquinolines
    Patent number: 8877929
    Abstract: The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: November 4, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shawn A. Springfield, Wendel W. Doubleday, Percy Sarwood Manchand
  • Methods of making HIV attachment inhibitor prodrug compound and intermediates
    Patent number: 8436168
    Abstract: A method for making the compound of Formula I: is set forth using alkylation, amidation, chlorination and phosphate installation procedures.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: May 7, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jonathan Clive Tripp, Dayne Dustan Fanfair, Mitchell J. Schultz, Saravanababu Murugesan, Richard J. Fox, Chung-Pin H. Chen, Sabrina E. Ivy, Joseph Francis Payack, Wendel W. Doubleday
  • METHODS OF MAKING HIV ATTACHMENT INHIBITOR PRODRUG COMPOUND AND INTERMEDIATES
    Publication number: 20130030178
    Abstract: A method for making the compound of Formula I: is set forth using alkylation, amidation, chlorination and phosphate installation procedures.
    Type: Application
    Filed: January 27, 2012
    Publication date: January 31, 2013
    Inventors: Jonathan Clive Tripp, Dayne Dustan Fanfair, Mitchell J. Schultz, Saravanababu Murugesan, Richard J. Fox, Chung-Pin H. Chen, Sabrina E. Ivy, Joseph Francis Payack, Wendel W. Doubleday
  • Process for synthesizing substituted isoquinolines
    Patent number: 8357806
    Abstract: The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: January 22, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shawn A. Springfield, Wendel W. Doubleday, Frederic Buono, Michel A. Couturier, Yvonne Lear, Denis Favreau, Kathia Levesque, Percy Sarwood Manchand, Markus Frieser, Anthony J. Cocuzza
  • Process for Synthesizing Substituted Isoquinolines
    Publication number: 20120220774
    Abstract: The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.
    Type: Application
    Filed: May 10, 2012
    Publication date: August 30, 2012
    Inventors: Shawn A. Springfield, Wendel W. Doubleday, Frederic Buono, Michel A. Couturier, Yvonne Lear, Denis Favreau, Kathia Levesque, Percy Sarwood Manchand, Markus Frieser, Anthony J. Cocuzza
  • Process or synthesizing substituted isoquinolines
    Patent number: 8207341
    Abstract: The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: June 26, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shawn A. Springfield, Wendel W. Doubleday, Percy Sarwood Manchand, Hyungcheol Kim, Sangsoo Lee, Chunyoung Kim, Soonha Yang, Eunhee Choi
  • Process for Synthesizing Substituted Isoquinolines
    Publication number: 20100056792
    Abstract: The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process.
    Type: Application
    Filed: August 25, 2009
    Publication date: March 4, 2010
    Inventors: Shawn A. Springfield, Wendel W. Doubleday, Frederic Buono, Michel A. Couturier, Yvonne Lear, Denis Favreau, Kathia Levesque, Percy Sarwood Manchand, Markus Frieser, Anthony J. Cocuzza, Hyungcheol Kim, Sangsoo Lee, Chunyoung Kim, Soonha Yang, Eunhee Choi
  • Process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-penty noate
    Patent number: 5631399
    Abstract: The present invention relates to a novel process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentyno ate and pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: May 14, 1996
    Date of Patent: May 20, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Kevin A. Babiak, Srinivasan Babu, James R. Behling, Mark L. Boys, Kimberly J. Cain-Janicki, Wendel W. Doubleday, Payman Farid, Timothy J. Hagen, E. A. Hallinan, Donald W. Hansen, Jr., Donald E. Korte, Kathleen T. Mc Laughlin, John R. Medich, Sean T. Nugent, Vlasdislav Orlovski, Jung M. Park, Karen B. Peterson, Daniel R. Pilipauskas, Barnett S. Pitzele, Sofya Tsymbalov, Glenn L. Stahl
  • Process for the preparation of ethyl 3S-[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentyn oate
    Patent number: 5536869
    Abstract: The present invention relates to a novel process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentyno ate and pharmaceutically acceptable acid addition salt thereof which comprises treating (trimethylsilyl)acetylene sequentially with n-butyllithium and 4-formylmorpholine followed by acid hydrolysis to give 3-(trimethylsilyl)-2-propynal; treating 3-(trimethylsilyl)-2-propynal with lithium bis(trimethylsilyl)amide to give in situ N,3-bis(trimethylsilyl)-2-propyn-1-imine; condensation of N,3-bis(trimethylsilyl)-2-propyn-1-imine with lithium t-butyl acetate to give (.+-.)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate; treating (.+-.)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate- with p-toluenesulfonic acid to give (.+-.)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate, mono p-toluenesulfonic acid salt, treatment of resulting salt with ethanol in the presence of p-toluenesulfonic acid to give (.+-.
    Type: Grant
    Filed: July 14, 1995
    Date of Patent: July 16, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Kevin A. Babiak, Srinivasan Babu, James R. Behling, Mark L. Boys, Kimberly J. Cain-Janicki, Wendel W. Doubleday, Payman Farid, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Jr., Donald E. Korte, Kathleen T. McLaughlin, John R. Medich, Sean T. Nugent, Vlasdislav Orlovski, Jung M. Park, Karen B. Peterson, Daniel R. Pilipauskas, Barnett S. Pitzele, Sofya Tsymbalov, Glenn L. Stahl