Abstract: A wheel retention system for use on the chassis of a large motor vehicle such as a tractor-trailer. Three support members are removably secured to the chassis and the support members support a retaining member positioned proximate to and parallel with the outer sidewalls of the wheels of the vehicle, forming a perimeter around the wheels. A pair of cylindrical sleeves axially and rotatably mounted upon the retaining member, the sleeves being positioned to confront a rotating wheel upon dislodging of the wheel from the chassis. The pair of support members comprise square tubing and completely pass from one side of the chassis to the other side of the chassis. The middle portion of each support member comprises an axle-retaining portion to trap an axle of the vehicle, should the axle disengage from the chassis.