Patents by Inventor Wendy J. Fantl

Wendy J. Fantl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for diagnosis prognosis and methods of treatment
    Publication number: 20090098594
    Abstract: This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of cells present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens. The physiological status of a cell can be determined by comparing the intracellular status of one or more activation elements (e.g. the phosphorylation status of a signaling molecule) in a cell (e.g. a cancer cell) to that of another cell (e.g. a normal cell). The physiological status of a cell can be further classified by adding one or more modulators (e.g. an inhibitor or activator) to the cell in question. In some embodiments, the invention is directed to methods of determining a phenotypic profile of a population of cells.
    Type: Application
    Filed: August 21, 2008
    Publication date: April 16, 2009
    Applicant: Nodality, Inc.
    Inventors: Wendy J. Fantl, Santosh K. Putta, Omar D. Perez, Helen L. Francis-Lang, Aileen C. Cohen
  • Sos1 inhibitors
    Publication number: 20080219968
    Abstract: Inhibitors of human Sos1, including antisense oligonucleotides, methods, and compositions specific for human Sos1, are provided. Methods of using the compositions for modulating Sos1 expression and for regulating cell growth, particularly tumor cell growth, are also provided.
    Type: Application
    Filed: September 20, 2007
    Publication date: September 11, 2008
    Applicant: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Birgit K. Jaitner, Wendy J. Fantl
  • Sos1 inhibitors
    Patent number: 7291725
    Abstract: Inhibitors of human Sos1, including antisense oligonucleotides, methods, and compositions specific for human Sos1, are provided. Methods of using the compositions for modulating Sos1 expression and for regulating cell growth, particularly tumor cell growth, are also provided.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: November 6, 2007
    Assignee: Chiron Corporation
    Inventors: Birgit K. Jaitner, Wendy J. Fantl
  • Isolation of drosophila and human polynucleotides encoding PAR-1 kinase, polypeptides encoded by the polynucleotides and methods utilizing the polynucleotides and polypeptides
    Publication number: 20020115167
    Abstract: Isolated nucleic acid molecules comprising polynucleotide having sequences that encode human and Drosophila PAR-1 kinases. Also provided are proteins and polypeptides encoded by the nucleic acid molecules, methods of modulating PAR-1 expression and function, and methods of modulating the Wnt signaling pathway.
    Type: Application
    Filed: July 30, 2001
    Publication date: August 22, 2002
    Inventors: Tian-Qiang Sun, Jia-Jia Feng, Christoph Reinhard, Wendy J. Fantl, Lewis T. Williams