Abstract: Methods and apparatus to operate closed-lid portable computers are disclosed. An example portable computer includes a first display on a lid of the portable computer, the first display to be deactivated when the lid is in a closed position; a second display distinct from the first display, the second display to be visible when the lid is in the closed position; instructions; and processor circuitry to execute the instructions to cause activation of the first display in response to a user interaction with the second display while the lid is in the closed position.

Abstract: The present disclosure provides a method of modifying a globin gene in the genome of a hematopoietic stem/progenitor cell (HSPC), the method comprising: A) obtaining HSPCs from an individual having a globin gene comprising a sickle cell disease (SCD)-associated single nucleotide polymorphism (SNP) to generate an in vitro population of CD34+ HSPCs and B) contacting the in vitro population with a genome editing composition, as described in further detail below. Also provided is a method of treating sickle cell disease (SCD) in an individual including administering to an individual an in vitro mixed population derived from the method of modifying a globin gene, as well as kits for practicing the same.