Patents by Inventor Wendy Uyen Dittmer

Wendy Uyen Dittmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200049807
    Abstract: An ultrasound system (100) for imaging a volumetric region comprising a region of interest (12) comprising: a probe having an array of CMUT transducers (14) adapted to transmit ultrasound beams and receive returning echo signals over the volumetric region; a beamformer (64) coupled to the array and adapted to control ultrasound beam transmission and provide ultrasound image data of the volumetric region; a transducer controller (62) coupled to the beamformer and adapted to vary driving pulse characteristics of the CMUT transducers, a region of interest identifier (72) enabling an identification of a region of interest on the basis of the ultrasound image data; a beam path analyzer (70) responsive to the ROI identification and arranged to detect an attenuating tissue type in between the probe and the ROI based on a depth variation in attenuation of the received signal; wherein the transducer controller is further adapted to change, based on the attenuating tissue type detection, at least one parameter of the d
    Type: Application
    Filed: October 25, 2017
    Publication date: February 13, 2020
    Inventors: Martin Pekar, Wendy Uyen Dittmer
  • Patent number: 10151750
    Abstract: A detection method (200) detects analytes in a fluid sample. The detection method includes transporting magnetic and/or electric labels (5) after interaction between the sample fluid and a reagent towards a detection receptacle (1). The detection receptacle (1) is initially substantially magnetic and/or electric label (5) free. By transporting the magnetic and/or electric labels (5) after reaction, interference between unreacted reagents and magnetic and/or electric label-assisted detection can be reduced.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: December 11, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Wendy Uyen Dittmer, Menno Willem Jose Prims
  • Publication number: 20180306919
    Abstract: An ultrasound system (100) for providing an ultrasound image of a volumetric region comprising a region of interest (12) comprising: a probe (10) having an array of CMUT transducers (14); a beamformer (64) coupled to the array and adapted to control the ultrasound beam steering and provide an ultrasound image data of the volumetric region; a transducer frequency controller (62) coupled to the beamformer and adapted to vary operation frequencies of the CMUT transducers within the frequency range, which frequency controller is arranged to set the operation frequency to a first frequency for the ultrasound beam steered in the volumetric region and to set the operation frequency to a second frequency for the ultrasound beams steered within the region of interest, the second frequency being higher than the first frequency; wherein the system further comprises an interferer analyzer (69) coupled to the transducer frequency controller (62), said interferer analyzer is adapted to vary at least one of beam steering pa
    Type: Application
    Filed: October 28, 2016
    Publication date: October 25, 2018
    Inventors: ANTONIA CORNELIA (JEANNET) VAN RENS, WENDY UYEN DITTMER
  • Publication number: 20180246208
    Abstract: The invention relates to an ultrasound system for imaging a volumetric region comprising a region of interest comprising: a probe having an array of CMUT transducers adapted to steer ultrasound beams in a variable frequency range over the volumetric region; a beamformer coupled to the array and adapted to control the ultrasound beam steering and provide ultrasound image data of the volumetric region; a transducer frequency controller coupled to the beamformer and adapted to vary operation frequencies of the CMUT transducers within the frequency range, which frequency controller is arranged to set the operation frequency to a first frequency for the ultrasound beam steered in the volumetric region; an image processor responsive to the ultrasound image data, based on which it is adapted to produce an ultrasound image.
    Type: Application
    Filed: September 9, 2016
    Publication date: August 30, 2018
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: WENDY UYEN DITTMER, ANTONIA CORNELIA (JEANNET) VAN RENS
  • Patent number: 9983128
    Abstract: A first output light beam (L2) that originates from a total internal reflection at a detection surface (111) of a total internal reflection TIR chamber (110) and a second output light beam (L2?) that comes from the interior of an inspectable chamber (120, 220, 320, 420, 520, 620) are both received within an observation region (OR). Preferably, these output light beams are detected with the same light detector, e.g. an image sensor (12). A total internal reflection at the TIR chamber and reflected light from inside the inspectable chamber are both directed to the same observation region (OR). This is for example enabled by different inclinations of the windows encountered by the first and the second output light beams, by different optical elements (407) in the paths of the output light beams, and/or by light scattering surface structures (122, 223, 322, 422, 522, 622) in the inspectable chamber.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: May 29, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jacobus Hermanus Maria Neijzen, Wendy Uyen Dittmer
  • Patent number: 9841421
    Abstract: The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an “auxiliary parameter” is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR).
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: December 12, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Wendy Uyen Dittmer, Mikhail Mikhaylovich Ovsyanko, Toon Hendrik Evers, Jeroen Hans Nieuwenhuis, Joannes Baptist Adrianus Dionisius Van Zon
  • Patent number: 9823241
    Abstract: A cartridge (110) and a method process target components (T1, T2) of a sample fluid, for example the detection of cardiac markers in blood. The cartridge (110) includes a reaction chamber (114) with a hydrophilic reaction surface (115). A physical barrier (116,118) on the reaction surface (115), for example a protrusion, at least partially borders an investigation region (117,117?) which includes capture probes (CP1, CP2) that specifically bind to target components (T1, T2) of the sample fluid.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: November 21, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Joost Hubert Maas, Wendy Uyen Dittmer, Mara Johanna Jacoba Sijbers, Albert Hendrik Jan Immink, Dominique Maria Bruls, Joukje Garrelina Orsel
  • Patent number: 9720003
    Abstract: The present invention relates to a method for measuring Troponin I in a sample comprising the steps of providing a sample, contacting the sample with a monoclonal anti-Troponin I antibody coupled to a magnetic label, contacting the sample with a polyclonal anti-Troponin I antibody coupled to a sensor surface and detecting the magnetic label on the sensor surface. The invention further relates to a device and a cartridge for measuring Troponin I in a sample.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: August 1, 2017
    Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Wendy Uyen Dittmer, Toon Hendrik Evers, Peggy De Kievit, Ricky Kamps, Joost Lambert Max Vissers, Michael Franciscus Wilhelmus Cornelis Martens, David Walterus Cornelis Dekkers
  • Patent number: 9557328
    Abstract: A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40?).
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: January 31, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Wendy Uyen Dittmer, Femke Karina De Theije, Albert Hendrik Jan Immink, Jeroen Hans Nieuwenhuis, Petrus Johannes Wilhelmus Van Lankvelt
  • Patent number: 9500584
    Abstract: An apparatus for examination of a sample includes at least one sample chamber in which the sample can be provided, where the sample chamber has a detection surface; at least one light source for emitting a first input light beam which is totally internally reflected at the detection surface of the sample chamber into a first output light beam, and for emitting a second input light beam which is at least partially transmitted through the sample chamber into a second output light beam. The apparatus further includes at least one light detector for detecting the first and the second output light beams. The sample chamber is elongated and traversed in longitudinal direction by light of the second input light beam.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: November 22, 2016
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jacobus Hermanus Maria Neijzen, Wendy Uyen Dittmer, Mikhail Mikhaylovich Ovsyanko
  • Publication number: 20150168390
    Abstract: The invention relates to a cartridge (110) and a method for the processing of target components (T1, T2) of a sample fluid, for example the detection of cardiac markers in blood. The cartridge (110) comprises a reaction chamber (114) with a hydrophilic reaction surface (115). A physical barrier (116,118) on the reaction surface (115), for example a protrusion, at least partially borders an investigation region (117,117?) which comprises capture probes (CP1, CP2) that specifically bind to target components (T1, T2) of the sample fluid.
    Type: Application
    Filed: July 3, 2013
    Publication date: June 18, 2015
    Inventors: Joost Hubert Maas, Wendy Uyen Dittmer, Mara Johanna Jacoba Sijbers, Albert Hendrik Jan Immink, Dominique Maria Bruls, Joukje Garrelina Orsel
  • Patent number: 9023651
    Abstract: The invention relates to a method and a device (100) for determining the amount of a target component (2) in a sample, wherein magnetic particles (2) can bind to a contact surface (4) with kinetics that depend on the sample-amount of the target component. The method comprises at least two washing steps during which magnetic particles (2) are magnetically moved away from the contact surface (4) and corresponding measurements of the remaining amount of magnetic particles (2) at the contact surface (4). The amount of target component in the sample is estimated from at least one of such measurement results. The measurement allows to determine also high concentrations of target component for which the sensor surface (4) is saturated in a steady-state.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: May 5, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Toon Hendrik Evers, Wendy Uyen Dittmer
  • Publication number: 20150104784
    Abstract: A detection system (100) is described for detecting analytes in a fluid sample. The detection system (100) comprises a transporting means (6) for transporting magnetic and/or electric labels (5) after interaction between the sample fluid and the reagents towards a detection receptacle (1). The detection receptacle (1) is initially substantially magnetic and/or electric label (5) free. By transporting the magnetic and/or electric labels (5) after reaction, interference between unreacted reagents and magnetic and/or electric label-assisted detection can be reduced.
    Type: Application
    Filed: December 15, 2014
    Publication date: April 16, 2015
    Inventors: Wendy Uyen DITTMER, Menno Willem Jose PRIMS
  • Patent number: 8936932
    Abstract: A detection system (100) is described for detecting analytes in a fluid sample. The detection system (100) comprises a transporting means (6) for transporting magnetic and/or electric labels (5) after interaction between the sample fluid and the reagents towards a detection receptacle (1). The detection receptacle (1) is initially substantially magnetic and/or electric label (5) free. By transporting the magnetic and/or electric labels (5) after reaction, interference between unreacted reagents and magnetic and/or electric label-assisted detection can be reduced.
    Type: Grant
    Filed: October 5, 2007
    Date of Patent: January 20, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Wendy Uyen Dittmer, Menno Willem Jose Prins
  • Publication number: 20150004624
    Abstract: A method of determining a presence of target molecules in a body fluid (16) with cells comprises the steps of: lysing cells in the body fluid (16) for generating a lysate (17); mixing the lysate (16) with particles (36) with first detector molecules; binding target molecule to the particles through first detector molecules; exposing a substrate (38) with second detector molecules to the lysate (17); binding target molecules to the substrate through second detector molecules; detecting particles (36) attached to the substrate (36).
    Type: Application
    Filed: January 14, 2013
    Publication date: January 1, 2015
    Inventors: Peggy De Kievit, Bram De Regt, Wendy Uyen Dittmer, Joukje Garrelina Orsel
  • Publication number: 20140379365
    Abstract: A medical system (10) which presents consumer health results includes a consumer questionnaire unit (14), a workflow assistant (20), a risk assessor (26), a guideline interpreter (28), and a display device (36). The consumer questionnaire unit (14) identifies consumer habits based on received responses to personal, medical, and lifestyle questions. The workflow assistant (20) iteratively identifies medical tests for the consumer based on a rule based evaluation of responses and received medical test results. The risk assessor (26) calculates a health risk to the consumer based on the identified habits and lifestyle behaviors and received medical test results, and determines body damage to the consumer based on received medical test results. The guideline interpreter (28) constructs a lifestyle advice display based on the identified consumer habits, the calculated health risk, the determined body damage, and lifestyle advice. The display device (36) displays the lifestyle advice display.
    Type: Application
    Filed: June 23, 2014
    Publication date: December 25, 2014
    Inventors: LEONTIEN DE ROODE, LEONIE FRANCELLE WAANDERS, WENDY UYEN DITTMER, NAGARAJU BUSSA, VIKRAM BASAWARAJ PATIL OKALY, MARCIA ALVES DE INDA, ARUN KUMAR MANI
  • Publication number: 20140286826
    Abstract: The invention relates to a cartridge (400), a sensor device, and a method for the optical examination of a sample. A first output light beam that originates from a total internal reflection at a detection surface of a TIR chamber and a second output light beam (L2?) that comes from the interior of an inspectable chamber (420) are both received within an observation region (OR). Preferably, these output light beams are detected with the same light detector, e.g. an image sensor. The invention hence allows for observing a total internal reflection at the TIR chamber and for looking into the inspectable chamber (420) from the same observation region (OR). This is for example enabled by different inclinations of the windows encountered by the first and the second output light beams, by different optical elements (407) in the paths of the output light beams, and/or by light scattering surface structures in the inspectable chamber.
    Type: Application
    Filed: October 29, 2012
    Publication date: September 25, 2014
    Inventors: Jacobus Hermanus Maria Neijzen, Wendy Uyen Dittmer
  • Publication number: 20140136226
    Abstract: A system (1) for computing a disease risk score of a patient based on a recommendation of treatment or lifestyle changes is disclosed. The system comprises an input device (11) for receiving risk parameter values for computing the disease risk score according to a risk score algorithm, and for receiving the recommendation of treatment or lifestyle changes, an interpreter (21) for computing at least one risk parameter value for computing the disease risk score, on the basis of the recommended treatment or lifestyle changes, a risk calculator (31) for calculating the disease risk score on the basis of the received risk parameter values and the computed risk parameter value, and an output device (41) for communicating the calculated disease risk score. Thanks to the interpreter (21), the recommended treatment or lifestyle change is “translated” into a value of a risk parameter for computing the disease risk score, there by allowing calculating the risk score resulting from the treatment or lifestyle change.
    Type: Application
    Filed: July 4, 2012
    Publication date: May 15, 2014
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Wendy Uyen Dittmer, Leonie Francelle Waanders, Harsh Dhand, Nagaraju Bussa, Marcia Alves De Inda, Arun Kumar Mani, Janke Jörn Dittmer
  • Publication number: 20140118745
    Abstract: The invention relates to means for the examination of a sample, wherein a first input light beam (L1) is totally internally reflected at a detection surface of a sample chamber (111), while a second input light beam (L1?) is transmitted through the sample chamber (111). The resulting first and second output light beams (L2, L2?) are detected and can be evaluated with respect to frustrated total internal reflection and optical absorbance, respectively. Preferably, both output light beams (L2, L2?) are detected by a single image sensor (155).
    Type: Application
    Filed: June 25, 2012
    Publication date: May 1, 2014
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Jacobus Hermanus Maria Neijzen, Wendy Uyen Dittmer, Mikhail Mikhaylovich Ovsyanko
  • Publication number: 20140057366
    Abstract: The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an “auxiliary parameter” is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR).
    Type: Application
    Filed: November 28, 2011
    Publication date: February 27, 2014
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Wendy Uyen Dittmer, Mikhail Mikhaylovich Ovsyanko, Toon Hendrik Evers, Jeroen Hans Nieuwenhuis, Joannes Baptist Adrianus dionisius Van Zon