Abstract: This invention pertains to a topically applied composition with a virucidal impact on mucocutaneous tissue. Ingredients essential to the efficacy of the formulated combination include a polyethylene glycol polymer known as Nonoxynol-9("N-9")in admixture with selected fat soluble vitamins A, D and E in the form of vegetable oil (and) retynyl palmitate (and) ergocalciferol together with tocopherol acetate. The invention is directed particularly to inactivation of herpes virus and human papilloma virus as manifested in cold sores, lesions, fever blisters, canker sores and warts. The N-9 contains viral activity while the vitamins effect restoration and strengthening of the damaged tissue cells.