Abstract: A method for preparing voriconazole L-camphorsulphonate and voriconazole. The method for preparing voriconazole L-camphorsulphonate comprises: method 1: dissolving (2R,3S)/(2S,3R) isomer mixture and L-camphor sulphonic acid in water and acetone, and performing crystallisation filtration to obtain voriconazole L-camphorsulphonate; method 2: (a) dissolving a mixture of isomer mixture and L-camphor sulphonic acid in a first solvent and then performing crystallisation filtration; or (a?) dissolving L-camphorsulphonate of the isomer mixture in a first solvent and then performing crystallisation filtration; (b) concentrating the filtrate obtained in step (a) or (a?) into a solid; and (c) dissolving the solid obtained in step (b) in a second solvent and performing crystallisation filtration to obtain voriconazole L-camphorsulphonate. Adjusting the resolution solvent effectively reduces production costs and facilitates recycling of the resolution solvent.

Abstract: A peridynamics method and system for tunnel rock mass failure water inrush catastrophe simulation. A calculation model is discretized into material points, and a virtual boundary layers is set on an outer side of a boundary of the calculation model as an object to which boundary conditions are applied; a size of a horizon of the material points is selected to form a neighborhood matrix; a crustal stress is made equivalent to a stress boundary condition of the calculation model, a karst cave water pressure is made equivalent to a normal pressure, and a displacement constraint and tunnel support are converted into a displacement boundary condition; a speed and a displacement of the material point are solved, and local damage situations are recorded; and a tunnel construction process is simulated by material point dormancy after initial balance calculation is stable.

Abstract: A test device and a test method of fractured rock mass collapse and blockfall and fracture water inrush includes a fractured rock mass preparation device, a water source loading device, a surrounding rock pressurization device and a slide rail, wherein the fractured rock mass preparation device is fixed at one end of the slide rail, and the water source loading device is fixed on the other side of the slide rail. An opening is formed in the rock mass water storage structure, and the size of the opening is adapted to the size of the fractured rock mass; the surrounding rock pressurization device includes one bracket and a pressurization structure arranged below the bracket, and a space for accommodating the fractured rock mass is reserved below the pressurization structure; and the bottom support and the bracket are both movably installed on the slide rail.

Abstract: A test device and a test method of fractured rock mass collapse and blockfall and fracture water inrush includes a fractured rock mass preparation device, a water source loading device, a surrounding rock pressurization device and a slide rail, wherein the fractured rock mass preparation device is fixed at one end of the slide rail, and the water source loading device is fixed on the other side of the slide rail. An opening is formed in the rock mass water storage structure, and the size of the opening is adapted to the size of the fractured rock mass; the surrounding rock pressurization device includes one bracket and a pressurization structure arranged below the bracket, and a space for accommodating the fractured rock mass is reserved below the pressurization structure; and the bottom support and the bracket are both movably installed on the slide rail.