Abstract: The present invention provides a compound represented by formula I, a racemate, an enantiomer, a diastereoisomer and a pharmaceutically acceptable salt thereof, and their use in preventing or treating a related disease caused by coronavirus and/or picornavirus infection.

Abstract: The present invention relates to a hexapeptide, a cosmetic composition or a pharmaceutical composition thereof, and a use thereof, the peptide has the following general formula: R1-Phe-Phe-Trp-Phe-X1-X2-R2. The peptide of the present invention, a stereoisomer thereof, or a mixture of stereoisomers thereof, or a cosmetically acceptable salt thereof, or a pharmaceutically acceptable salt thereof, or their cosmetic compositions or pharmaceutical compositions, and their uses in the preparation of a cosmetic composition or a pharmaceutical composition for anti-inflammation and skin barrier repair.

Abstract: Techniques are described for controlling and/or managing a model applied to a wireless communication system. An example wireless communication method comprises transmitting, by a first wireless device to a second device located in a network, a first message that requests a model information; and receiving, by the first wireless device, a second message in response to the transmitting the first message, where the second message includes a model description information that describes one or more characteristics of a model to be used by the first wireless device.

Abstract: A sacubitril valsartan sodium sustained-release composition is a 24-hour sustained-release drug. Dissolution of sacubitril and valsartan simultaneously satisfies the following three features: A) dissolving no more than 40% of pharmaceutical active ingredients within 2 hours; B) dissolving 20%-75% of the pharmaceutical active ingredients within 8 hours; and C) dissolving not less than 65% of the pharmaceutical active ingredients within 24 hours. Compared with common gel sustained-release dosage forms, sacubitril and valsartan in the composition can achieve synchronous sustained release; moreover, the drug release behavior is not affected by factors such as the pH of a medium environment, gastrointestinal peristalsis, and foods, the in vivo and in vitro correlation is good, gentle release within 24 hours is achieved, and the therapeutic effect is good.

Abstract: A peptide derivative and a cosmetic composition or pharmaceutical composition and use thereof. The peptide derivative has the following general formula: R1—Pro-Lys-Glu-Lys-R2. The peptide derivative is obtained by means of covalent binding of niacin, tranexamic acid or kojic acid with a peptide, has the effects of relieving skin inflammation reaction and inhibiting melanin generation, and can be used in the fields of cosmetics or medicines for anti-inflammation as well as whitening and freckle-removing of skin, especially for improving post-inflammation hyperpigmentation.

Abstract: Provided are a peptide derivative and a cosmetic composition or pharmaceutical composition and use thereof. The peptide derivative has a general formula as follows: R1-Gly-Pro-Gln-Gly-Pro-Gln-R2. The peptide derivative is obtained by covalently binding caffeic acid and gallic acid to peptide, respectively; and compared with single caffeic acid, gallic acid and single polypeptide, the peptide derivative has excellent skin photoaging and anti-oxidation effects, and can be applied to the fields of cosmetics, medicines, and the like.

Abstract: Network wavefield imaging methods are able to image significantly complex discontinuities or shapes in plate-like structures for superior ultrasonic structural health monitoring (SHM)/nondestructive evaluation (NDE). The imaging provides high-resolution location, shape and/or size images of a structure, and for discontinuities with more complicated profiles. Guided wave (GW) network wavefield imaging methods combine tomography and wavefield/wavenumber imaging algorithms. Metallic plate damage detection uses guided ultrasonic waves and non-contact laser vibrometry. Guided waves are generated by piezoelectric transducers (PZT). A non-contact scanning laser Doppler vibrometer (SLDV) measures the full velocity plate guided wave wavefields. Developed network wavefield imaging algorithms account for multiple-actuator excitations from different angles enclosing the discontinuity, with algorithms using intrinsic wave characteristics such as wavefield, wavenumber, or reconstructed wave energy.

Abstract: Network wavefield imaging methods are able to image significantly complex discontinuities or shapes in plate-like structures for superior ultrasonic structural health monitoring (SHM)/nondestructive evaluation (NDE). The imaging provides high-resolution location, shape and/or size images of a structure, and for discontinuities with more complicated profiles. Guided wave (GW) network wavefield imaging methods combine tomography and wavefield/wavenumber imaging algorithms. Metallic plate damage detection uses guided ultrasonic waves and non-contact laser vibrometry. Guided waves are generated by piezoelectric transducers (PZT). A non-contact scanning laser Doppler vibrometer (SLDV) measures the full velocity plate guided wave wavefields. Developed network wavefield imaging algorithms account for multiple-actuator excitations from different angles enclosing the discontinuity, with algorithms using intrinsic wave characteristics such as wavefield, wavenumber, or reconstructed wave energy.