Patents by Inventor Wenfeng Xu

Wenfeng Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN CYTOKINE RECEPTOR
    Publication number: 20080242839
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.
    Type: Application
    Filed: July 24, 2007
    Publication date: October 2, 2008
    Inventors: Scott R. Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen
  • ANTI-IL-20 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION
    Publication number: 20080233115
    Abstract: The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-20 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. The present invention includes anti-IL-20 and anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
    Type: Application
    Filed: November 27, 2007
    Publication date: September 25, 2008
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Yasmin A. Chandrasekher, Stacey R. Dillon, Joyce M. Lehner, Anthony W. Siadak, Pallavur V. Sivakumar, Margaret D. Moore
  • HUMAN CYTOKINE RECEPTOR
    Publication number: 20080214785
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.
    Type: Application
    Filed: July 27, 2007
    Publication date: September 4, 2008
    Inventors: Scott R. Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen, Steven D. Hughes
  • Immunoconjugates of anti-IL-20 antibodies and hybridoma cell lines expressing anti-IL-20 antibodies
    Patent number: 7393684
    Abstract: The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: July 1, 2008
    Assignee: ZymoGenetics, Inc.
    Inventors: Wenfeng Xu, Wayne R. Kindsvogel, Zhi Chen, Steven D. Hughes, Yasmin A. Chandrasekher, Stacey R. Dillon, Joyce M. Lehner, Anthony W. Siadak, Pallavur V. Sivakumar, Margaret D. Moore
  • Soluble interleukin-20 receptor
    Patent number: 7387780
    Abstract: A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: June 17, 2008
    Assignee: ZymoGenetics, Inc.
    Inventors: Donald C. Foster, Wenfeng Xu, Karen L. Madden, James D. Kelly, Cindy A. Sprecher, Cameron S. Brandt, Mark W. Rixon, Scott R. Presnell, Brian A. Fox
  • MOUSE CYTOKINE RECEPTOR ZCYTOR16
    Publication number: 20080131931
    Abstract: Cytokines and their receptors have proven usefulness in both basic research, animal models, and as therapeutics. The present invention provides polynucleotides encoding a new cytokine receptor designated as “mouse Zcytor16”, which can bind and antagonize the IL-TIF cytokine. The present invention also provides corresponding vectors, cells, and methods of production.
    Type: Application
    Filed: January 18, 2008
    Publication date: June 5, 2008
    Inventors: Scott R. Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen
  • Mouse cytokine receptor Zcytor16
    Patent number: 7351555
    Abstract: Cytokines and their receptors have proven usefulness in both basic research, animal models, and as therapeutics. The present invention provides a new cytokine receptor designated as “mouse Zcytor16,” which can bind and antagonize the IL-TIF cytokine.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: April 1, 2008
    Assignee: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen
  • ANTI-IL-TIF ANTIBODIES AND METHODS OF USING IN INFLAMMATION
    Publication number: 20080033148
    Abstract: The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.
    Type: Application
    Filed: July 27, 2007
    Publication date: February 7, 2008
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Steven Hughes, Yasmin Chandrasekher
  • HUMAN CYTOKINE RECEPTOR
    Publication number: 20070299247
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.
    Type: Application
    Filed: July 26, 2007
    Publication date: December 27, 2007
    Inventors: Scott Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen, Steven Hughes
  • HUMAN TUMOR NECROSIS FACTOR RECEPTOR
    Publication number: 20070264689
    Abstract: Tumor necrosis factors and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human tumor necrosis factor receptor designated as “Ztnfr12.
    Type: Application
    Filed: June 22, 2007
    Publication date: November 15, 2007
    Inventors: Jane Gross, Wenfeng Xu, Randal Henne, Francis Grant
  • POLYNUCLEOTIDES ENCODING CYTOKINE RECEPTOR
    Publication number: 20070264685
    Abstract: Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: October 9, 2006
    Publication date: November 15, 2007
    Inventors: SCOTT PRESNELL, Wenfeng Xu, Julia Novak, Theodore Whitmore, Francis Grant, Wayne Kindsvogel, Kevin Klucher
  • Human cytokine receptor
    Patent number: 7265203
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: September 4, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen, Steven D. Hughes
  • Anti-IL-TIF antibodies and methods of making
    Patent number: 7265211
    Abstract: The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: September 4, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Steven D. Hughes, Yasmin A. Chandrasekher
  • HUMAN TUMOR NECROSIS FACTOR RECEPTOR POLYNUCLEOTIDES
    Publication number: 20070178492
    Abstract: Tumor necrosis factors and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human tumor necrosis factor receptor designated as “Ztnfr12.
    Type: Application
    Filed: November 13, 2006
    Publication date: August 2, 2007
    Inventors: JANE GROSS, Wenfeng Xu, Randal Henne, Francis Grant
  • METHODS OF USING SOLUBLE HETERODIMERIC CYTOKINE RECEPTOR
    Publication number: 20070173451
    Abstract: A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
    Type: Application
    Filed: March 26, 2007
    Publication date: July 26, 2007
    Inventors: Yasmin Chandrasekher, Julia Novak, Donald Foster, Wenfeng Xu, Stephen Jaspers
  • HUMAN CYTOKINE RECEPTOR
    Publication number: 20070166746
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.
    Type: Application
    Filed: February 1, 2007
    Publication date: July 19, 2007
    Inventors: Scott Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen
  • HUMAN CYTOKINE RECEPTOR
    Publication number: 20070148143
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.
    Type: Application
    Filed: February 1, 2007
    Publication date: June 28, 2007
    Inventors: Scott Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen
  • ANTIBODIES TO CYTOKINE RECEPTOR
    Publication number: 20070134727
    Abstract: Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: October 9, 2006
    Publication date: June 14, 2007
    Inventors: SCOTT PRESNELL, Wenfeng Xu, Julia Novak, Theodore Whitmore, Francis Grant, Wayne Kindsvogel, Kevin Klucher
  • HUMAN CYTOKINE RECEPTOR
    Publication number: 20070134745
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.
    Type: Application
    Filed: February 1, 2007
    Publication date: June 14, 2007
    Inventors: Scott Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen
  • HUMAN CYTOKINE RECEPTOR
    Publication number: 20070134237
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.
    Type: Application
    Filed: February 1, 2007
    Publication date: June 14, 2007
    Inventors: Scott Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen