Patents by Inventor Wenge Li
Wenge Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240092650Abstract: The present disclosure provides a method for improving a conductivity and a blue light filtering efficiency of a transparent conducting oxide (TCO). The method includes the following steps: placing an indium oxide-based transparent conducting material (TCM) as a sample into a sample chamber of a high-pressure apparatus, and conducting a room-temperature high-pressure treatment, where the room-temperature high-pressure treatment refers to compressing the sample to a target pressure of 51 GPa from ambient pressure at room temperature and holding the target pressure for 5 min, and then conducting decompression to the ambient pressure. The conductivity is detected during the compression and the decompression, and the blue light filtering efficiency is detected separately before and after the room-temperature high-pressure treatment.Type: ApplicationFiled: September 15, 2023Publication date: March 21, 2024Inventors: WENGE YANG, XUQIANG LIU, GANG LIU, NANA LI
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Publication number: 20240043364Abstract: A method for preparing 3,3?,4,4?-dicyclohexyltetracarboxylic acid and a method for treating an acidic wastewater are provided. In the preparation method according to the present disclosure, a ruthenium-rhodium mixed catalyst is used to catalyze the hydrogenation reduction reaction, which improves the selectivity of the reaction and reduces the generation of isomers, thereby reducing the generation of by-products and increasing the purity of 3,3?,4,4?-dicyclohexyltetracarboxylic acid. The results of the examples show that the purity of 3,3?,4,4?-dicyclohexyltetracarboxylic acid prepared by the method according to the present disclosure is not less than 99.62%.Type: ApplicationFiled: August 23, 2021Publication date: February 8, 2024Inventors: Shuai SHAO, Yuntang ZHANG,, Wenge LI, Yufen ZHANG, Jingxiao WANG, Feiyang WANG, Qin YAN, Xiao WANG, Tiecheng LIU
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Publication number: 20220259150Abstract: The present application provides a compound of formula II and a method for preparing a compound of formula I, i.e., 2-iso-propyl-4-methylpyridin-3-amine by using the same. The compound of formula I can be applied to synthesis of KRAS inhibitor drugs. The raw materials involved in the method of the present application are easy to obtain and low in price, operation is easy and convenient, economization and environmental protection are achieved, and industrial production is facilitated.Type: ApplicationFiled: September 10, 2020Publication date: August 18, 2022Inventors: Shengwen WU, Wenge LI, Peng ZHOU
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Patent number: 10183909Abstract: A process is provided for preparation of (R)-N-Boc biphenyl alaninol. It provides a preparation process for a compound outlined as compound 4, which includes these operations: in one of the alcohol solvents, asymmetric hydrogenation of 5 in the presence of [Rh(Duanphos)(X)]Y and hydrogen to provide compound 4. Here “Duanphos” is (Rc,Sp)-Duanphos or (Sc,Rp)-Duanphos; X is NBD or/and COD; Y is one or more of BF4, PF6, SbF6. This process has a lot of advantages, such as low cost, safe operation, less pollution and high yield. The product was obtained in >99% purity and ee which is suitable to scale up in industrial scale.Type: GrantFiled: September 9, 2016Date of Patent: January 22, 2019Assignees: CHIRAL QUEST (SUZHOU) CO., LTD., JIANGXI LONG LIFE BIO-PHARMACEUTICAL CO., LTD.Inventors: Shengwen Wu, Wenge Li, Lei Wu, Li Zou, Siming Hu, Tengyue Xu, Hongfeng Liu, Yi Tao, Yongxiang Chi
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Publication number: 20180297941Abstract: A process is provided for preparation of (R)—N-Boc biphenyl alaninol. It provides a preparation process for a compound outlined as compound 4, which includes these operations: in one of the alcohol solvents, asymmetric hydrogenation of 5 in the presence of [Rh(Duanphos)(X)]Y and hydrogen to provide compound 4. Here “Duanphos” is (Rc,Sp)-Duanphos or (Sc,Rp)-Duanphos; X is NBD or/and COD; Y is one or more of BF4, PF6, SbF6. This process has a lot of advantages, such as low cost, safe operation, less pollution and high yield. The product was obtained in >99% purity and ee which is suitable to scale up in industrial scale.Type: ApplicationFiled: September 9, 2016Publication date: October 18, 2018Applicants: CHIRAL QUEST (SUZHOU) CO., LTD., JIANGXI LONG LIFE BIO-PHARMACEUTICAL CO., LTD.Inventors: Shengwen WU, Wenge LI, Lei WU, Li ZOU, Siming HU, Tengyue XU, Hongfeng LIU, Yi TAO, Yongxiang CHI
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Patent number: 8957222Abstract: A process for preparing the S or R enantiomer of a compound of formula A, the process comprising subjecting a compound of formula B to asymmetric hydrogenation in the presence of a chiral transition metal catalyst and a source of hydrogen, wherein X is CH2, oxygen, or sulphur; R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino, or dialkylamino group; and R4 is alkyl or aryl, wherein the transition metal catalyst comprises a chiral ligand having the formula wherein p is from 1 to 6, and Ar means aryl group; wherein the term alkyl means hydrocarbon chains, straight or branched, containing from one to six carbon atoms, optionally substituted by aryl, alkoxy, halogen, alkoxycarbonyl or hydroxycarbonyl groups; the term aryl means an aromatic or heteroaromatic group, optionally substituted by alkyloxy, halogen, or nitro group; and the term halogen means fluorine, chlorine, bromine, or iodine.Type: GrantFiled: March 17, 2009Date of Patent: February 17, 2015Assignee: Bial-Portela & CA, S.A.Inventors: Alexander Beliaev, David Alexander Learmonth, Wenge Li
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Publication number: 20140322708Abstract: Methods are provided for determining if an agent causes somatic mutations in a genome, and kits, systems and computer-readable medium therefor.Type: ApplicationFiled: June 1, 2012Publication date: October 30, 2014Applicant: Albert Einstein College of Medicine of Yeshiva UniversityInventors: Jan Vijg, Michael Gundry, Wenge Li
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Patent number: 8558023Abstract: A process for preparing an enantiomerically enriched cycloalkene-substituted alanine compound having the structure: by asymmetrically hydrogenating a dehydro amino acid compound having the structure: in a suitable reaction media in the presence of a catalyst having a transition metal moiety complexed to a chiral phosphine ligand to prepare enantiomerically enriched cycloalkene substituted alanine compounds having the structure of Formula (IA) or (IB), which are key intermediates for the ACE inhibitors ramipril and perindolpril:Type: GrantFiled: April 20, 2011Date of Patent: October 15, 2013Assignee: Chiral Quest, Inc.Inventors: Zijun Liu, Sanhui Lin, Wenge Li, Jingyang Zhu, Xinjun Liu, Xiaojuan Zhang, Hui Lu, Fei Xiong, Zhongwei Tian
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Patent number: 8367821Abstract: A process for preparing a compound of the formula IA or IB: wherein R is alkyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, straight or branched, containing from 1 to 18 carbon atoms; the term halogen represents fluorine, chlorine, bromine or iodine; the term cycloalkyl represents a saturated alicyclic group with 3 to 6 carbon atoms; the term aryl represents unsubstituted phenyl group or phenyl substituted by alkoxy, halogen or nitro group, the process comprising asymmetric hydrogenation of a compound of the formula II: wherein R has the same meanings as above, using a chiral catalyst and a source of hydrogen.Type: GrantFiled: April 11, 2007Date of Patent: February 5, 2013Assignee: BIAL—Portela & C.A., S.A.Inventors: Bing Yu, Wenge Li, David Alexander Learmonth
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Publication number: 20110257408Abstract: A process for preparing an enantiomerically enriched cycloalkene-substituted alanine compound having the structure: by asymmetrically hydrogenating a dehydro amino acid compound having the structure: in a suitable reaction media in the presence of a catalyst having a transition metal moiety complexed to a chiral phosphine ligand to prepare enantiomerically enriched cycloalkene substituted alanine compounds having the structure of Formula (IA) or (IB), which are key intermediates for the ACE inhibitors ramipril and perindolpril:Type: ApplicationFiled: April 20, 2011Publication date: October 20, 2011Applicant: Chiral Quest, Inc.Inventors: Zijun Liu, Sanhui Lin, Wenge Li, Jingyang Zhu, Xinjun Liu, Xiaojuan Zhang, Hui Lu, Fei Xiong, Zhongwei Tian
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Publication number: 20110112303Abstract: A process for preparing the S or R enantiomer of a compound of formula A, the process comprising subjecting a compound of formula B to asymmetric hydrogenation in the presence of a chiral transition metal catalyst and a source of hydrogen, wherein X is CH2, oxygen, or sulphur; R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino, or dialkylamino group; and R4 is alkyl or aryl, wherein the transition metal catalyst comprises a chiral ligand having the formula wherein p is from 1 to 6, and Ar means aryl group; wherein the term alkyl means hydrocarbon chains, straight or branched, containing from one to six carbon atoms, optionally substituted by aryl, alkoxy, halogen, alkoxycarbonyl or hydroxycarbonyl groups; the term aryl means an aromatic or heteroaromatic group, optionally substituted by alkyloxy, halogen, or nitro group; and the term halogen means fluorine, chlorine, bromine, or iodine.Type: ApplicationFiled: March 17, 2009Publication date: May 12, 2011Applicant: BIAL - PORTELA & CA, S.A.Inventors: David Alexander Learmonth, Alexander Beliaev, Wenge Li
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Publication number: 20100217013Abstract: An enantioselective process for preparing zolmitriptan, (S)-4-{[3-[2-(dimethylamine)ethyl]-1H-indol-5-yl]methyl}-2-oxazolidinone), by asymmetric hydrogenation of (Z)-2-(acetylamino)-3-{[3-N,N-(dimethylamine)ethyl)-1H-indol-5-yl]-2-propenoic acid methyl ester in the presence of hydrogen and an enantioselective chiral phosphine transition metal catalyst.Type: ApplicationFiled: December 15, 2009Publication date: August 26, 2010Inventors: Wenge Li, Yongxiang Chi, Jingyang Zhu
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Publication number: 20100173893Abstract: A process for preparing a compound of the formula IA or IB: wherein R is alkyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, straight or branched, containing from 1 to 18 carbon atoms; the term halogen represents fluorine, chlorine, bromine or iodine; the term cycloalkyl represents a saturated alicyclic group with 3 to 6 carbon atoms; the term aryl represents unsubstituted phenyl group or phenyl substituted by alkoxy, halogen or nitro group, the process comprising asymmetric hydrogenation of a compound of the formula II: wherein R has the same meanings as above, using a chiral catalyst and a source of hydrogen.Type: ApplicationFiled: April 11, 2007Publication date: July 8, 2010Inventors: Bing Yu, Wenge Li, David Alexander Learmont