Abstract: The present invention provides a JAK inhibitor having high oral bioavailability, characterized in that the JAK inhibitor includes: a Formula I compound, or a stereoisomer, geometric isomer, tautomer, hydrate, solvate, or pharmaceutically acceptable salt thereof as an active ingredient. The JAK inhibitor with high oral bioavailability provided by the present invention can overcome the problem that existing JAK inhibitors have low oral bioavailability, and involves further modifying a chemical compound so as to change the physicochemical characteristics of one or several small molecule compounds, thus increasing the in-vivo cell absorption performance of said compound(s), greatly improving the bioavailability of the medication and providing new possibilities for drug delivery and utilization for said compound medication.

Abstract: A dispenser system for dispensing a fluid product comprises: an elongated container containing the fluid product to be dispensed, a pump assembly coupled with the elongate container from the distal end, a piston which is slidably positioned in the container at the closed proximal end and contacting with the fluid product, and a standing cap. The standing cap has an opening for engaging the pump assembly, and has a supporting structure opposite to the opening, wherein the supporting structure comprises one or more supporting sections that define a supporting plane, wherein the dispenser system, when in a main standing position, stands upon the supporting structure of the standing cap, with the closed proximal end of the elongated container is on the topmost. Further the supporting structure of the standing cap has a projected area on the supporting plane which is larger than the largest cross-sectional area of the elongated container.

Abstract: A Surface Acoustic Wave (SAW) Impedance Element Filter (IEF) comprises a cascade of Gamma sections. Each of the Gamma sections comprises a series SAW resonator and a shunt SAW resonator deposited in a surface of a piezoelectric substrate with an additional capacity connected in parallel to the shunt SAW resonator. All the series and shunt SAW resonators have pitches (P) which are substantially equivalent. The SAW IEF has smaller bandwidth to satisfy some specific applications.

Abstract: Provided is a small molecule compound, which is characterized in having the structure represented by the following molecular formula: (I), wherein X1 and X2 are selected from carbon or nitrogen; G1 is a carbocyclic ring or heterocyclic ring having aromaticity; any one or more hydrogen atoms on the ring of G1 are substituted by R1; and R1 is selected from nitrogen-containing groups. The small molecule compound of the present invention can be used as a highly effective and specific JAK kinase inhibitor, specifically a Tyk2 inhibitor; and/or a JAK1 inhibitor, and/or a JAK1/Tyk2 or Tyk2/JAK1, Tyk2/Jak2 dual inhibitor.

Abstract: A well tracking device includes a rectangular frame including four sidewalls. The sidewalls define sets of opposing grooves, and the well tracking device is configured to receive or fit on top of a multi-well plate. The well tracking device also includes a well coordinate indicator positioned on an upper portion of the rectangular frame, that includes labels associated with columns and/or rows of the multi-well plate. The well tracking device also includes at least one slider that is configured to interface with a set of opposing grooves and slide along a width or length of the rectangular frame. The slider includes a plurality of openings disposed along the elongated shape of the slider.

Abstract: A triazolo pyrazine compound, wherein the triazolo pyrazine compound is a compound as represented by formula (I) as follows, or a stereoisomer, a geometrical isomer, a tautomer, a hydrate, a solvate, and a pharmaceutically acceptable salt or a prodrug thereof, wherein W is selected from a substituted or unsubstituted aryl or heteroaryl, X is C or N, and R is H or any substituent group. When the triazolo pyrazine compound provided by the invention is used as a Tyk2 specific inhibitor, a more targeted drug can be provided for autoimmune inflammatory diseases driven by an IL-23/Th17 axis, and the compound can be used for treating rheumatoid arthritis, psoriasis, ankylosing spondylitis, sicca syndrome, lupus erythematosus, inflammatory bowel disease, Behcet's disease, severe COVID-19 pneumonia and other diseases more safely and effectively.

Abstract: The present invention provides a small molecule compound. The small molecule compound is a compound represented by the following formula (I), or a stereoisomer, geometric isomer, tautomer, hydrate, solvate, and pharmaceutically acceptable salt or prodrug thereof, wherein R1 to R5 are each independently selected from C or N; and R is selected from cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl. The small molecule compound of the present invention can inhibit the JAK kinase, and is particularly used as a JAK1/Tyk2 dual inhibitor and a Tyk2 specific inhibitor.

Abstract: A cross dipole antenna element may include a flexible substrate, a first pair of dipole arms disposed on the flexible substrate, a second pair of dipole arms disposed on the flexible substrate, a plurality of feed points disposed at a center portion of the flexible substrate and between the first and second pairs of dipole arms, a metallic plate forming a ground plane for the antenna element, and a dielectric spacer disposed between the center portion of the flexible substrate and the metallic plate. The first and second pairs of dipole arms may be operably coupled to the metallic plate at distal ends of the first and second pairs of dipole arms relative to the center portion.

Abstract: Provided in the present invention are a small molecule compound, which is the compound represented by formula (I), or a stereoisomer, a geometric isomer, a tautomer, a hydrate, a solvate, and a pharmaceutically acceptable salt or a prodrug thereof, where R1 to R4 are each independently selected from C or N, and wherein R is selected from a cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl. The small molecule compound of the present disclosure can inhibit a JAK kinase, and more particularly is used as a JAK1/Tyk2 dual inhibitor and a Tyk2 specific inhibitor.

Abstract: Provided in the present invention is a small molecule compound, which is characterized in that it is a compound or a stereoisomer, geometric isomer, tautomer, racemate, hydrate, solvate, metabolite, and pharmaceutically acceptable salt or prodrug of the compound as represented by the following structural formula: formula (I). The small molecule compound of the present invention is applicable as a highly efficient and specific JAK kinase inhibitor, specifically a Tyk2 inhibitor and/or a JAK1 inhibitor, and/or a JAK1/Tyk2 dual inhibitor.

Abstract: A dispenser system for dispensing a fluid product comprises: an elongated container containing the fluid product to be dispensed, a pump assembly coupled with the elongate container from the distal end, a piston which is slidably positioned in the container at the closed proximal end and contacting with the fluid product, and a standing cap. The standing cap has an opening for engaging the pump assembly, and has a supporting structure opposite to the opening, wherein the supporting structure comprises one or more supporting sections that define a supporting plane, wherein the dispenser system, when in a main standing position, stands upon the supporting structure of the standing cap, with the closed proximal end of the elongated container is on the topmost. Further the supporting structure of the standing cap has a projected area on the supporting plane which is larger than the largest cross-sectional area of the elongated container.

Abstract: An air-cooled diesel generator is provided, and relates to the technical field of diesel generator sets. The air-cooled diesel generator comprises a box body and multiple components provided in the box body, and each component is provided with a separate housing outside; a main air inlet and a main air outlet are formed in the box body, a sub-air inlet and a sub-air outlet are formed in each housing, each sub-air outlet communicates with the main air outlet through an air duct, and each sub-air inlet is provided with an air guide device. Therefore, the air-cooled diesel generator is provided which has better heat dissipation performance.

Abstract: A well tracking device includes a rectangular frame including four sidewalls. The sidewalls define sets of opposing grooves, and the well tracking device is configured to receive or fit on top of a multi-well plate. The well tracking device also includes a well coordinate indicator positioned on an upper portion of the rectangular frame, that includes labels associated with columns and/or rows of the multi-well plate. The well tracking device also includes at least one slider that is configured to interface with a set of opposing grooves and slide along a width or length of the rectangular frame. The slider includes a plurality of openings disposed along the elongated shape of the slider.

Abstract: The present technology relates to a customizable sample preparation device (e.g., liquid sample preparation device, such as a purification, clean-up, or separation device). In particular, the present technology relates to customizable devices formed from modular segments tailored to address one or more of the following: to optimize different sample and elution volumes, to incorporate various connection mechanisms to liquid handlers, to incorporate various liquid dispensing flow conditions, and to fulfill broad applications through the selection of specific resin for sample preparation. Some embodiments are directed to affinity capture devices, such as for example, Protein A affinity capture devices, utilizing a polymethacrylate-based resin. Other resins as well as other materials for processing a liquid sample are described herein.

Abstract: The present invention is a dual Ka-band, compact, high efficiency CP antenna cluster with dual band compact diplexers-polarizers that can be used as a basic building block for mobile satellite antenna arrays that require minimal dimensions and high efficiency.

Abstract: The present invention is a dual Ka-band, compact, high efficiency CP antenna cluster with dual band compact diplexers-polarizers that can be used as a basic building block for mobile satellite antenna arrays that require minimal dimensions and high efficiency.

Abstract: The present invention is a dual Ka-band, compact, high efficiency CP antenna cluster with dual band compact diplexers-polarizers that can be used as a basic building block for mobile satellite antenna arrays that require minimal dimensions and high efficiency.