Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are each independently hydrogen or hydroxy; wherein R1 and R2 are not both hydroxy. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations thereof with other therapeutic agents.

Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: In part, the invention provides a new combination comprising (1) a GLP-1R agonist and (2) an ACC inhibitor or a DGAT2 inhibitor, or a KHK inhibitor or FXR agonist. The invention further provides new methods for treating diseases and disorders, for example, fatty liver, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, nonalcoholic steatohepatitis with liver fibrosis, nonalcoholic steatohepotitis with cirrhosis, and nonalcoholic steatohepatitis with cirrhosis and with hepatocellular carcinoma or with a metabolic-related disease, obesity, and type 2 diabetes, for example, using the new combination described herein.

Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are each independently hydrogen or hydroxy; wherein R1 and R2 are not both hydroxy. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations thereof with other therapeutic agents.

Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: The present invention relates to a mobile communication field. The present invention provides a method and an apparatus for WiMAX positioning by downlink preamble fast detection DPFD. The method comprises steps of: Mobile user station MSS detects downlink preambles from BSs, all of which are synchronized by in TDD mode mobile WiMAX; the TDoA of different BSs' preamble is get through preamble-based synchronization detection; and the exact location is calculated through classical TDoA algorithms. The embodiment of the present invention describes a novel concept for measuring the position of the mobile user equipment by the uplink ranging assistant downlink preamble detection. With the mobile WiMAX is accepted as a 3G standard by ITU and widely populated, the position based on WiMAX will be a market-potential service.

Abstract: The present invention provides a method and an apparatus for topology aggregation and a routing controller. The method comprises: obtaining a link-diversity path number c(i,j,?k) between each pair of border nodes in a real topology GR; and obtaining a connectivity matrix C by utilizing said link-diversity path number c(i,j,?k) and constructing a corresponding full-mesh topology GB. Moreover, the method further comprises compressing the resulting full-mesh topology into a bi-directional shuffle-net topology using the genetic algorithm. Therefore, according the present invention, more link information can be provided for routing decision and more accurate topology can be provided.

Abstract: The present invention provides a method and an apparatus for topology aggregation and a routing controller. The method comprises: obtaining a link-diversity path number c(i,j,?k) between each pair of border nodes in a real topology GR; and obtaining a connectivity matrix C by utilizing said link-diversity path number c(i,j,?k) and constructing a corresponding full-mesh topology GB. Moreover, the method further comprises compressing the resulting full-mesh topology into a bi-directional shuffle-net topology using the genetic algorithm. Therefore, according the present invention, more link information can be provided for routing decision and more accurate topology can be provided.

Abstract: The present invention relates to a mobile communication field. The present invention provides a method and an apparatus for WiMAX positioning by downlink preamble fast detection DPFD. The method comprises steps of: Mobile user station MSS detects downlink preambles from BSs, all of which are synchronized by in TDD mode mobile WiMAX; the TDoA of different BSs' preamble is get through preamble-based synchronization detection; and the exact location is calculated through classical TDoA algorithms. The embodiment of the present invention describes a novel concept for measuring the position of the mobile user equipment by the uplink ranging assistant downlink preamble detection. With the mobile WiMAX is accepted as a 3G standard by ITU and widely populated, the position based on WiMAX will be a market-potential service.

Abstract: Dibenzyl amine compounds and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

Abstract: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.