Patents by Inventor Wenjian Liu

Wenjian Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11787801
    Abstract: The embodiments disclosed herein provide compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, or a pharmaceutically acceptable salt or solvate of the compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, wherein R1 to R7 are as defined in the description. This application also provides a preparation method and a medical use of the compounds. The compounds of this disclosure have an activity superior or equivalent to the candidate drug LY2835219 currently under phase III clinical trial, and some of the compounds exhibit better selectivity. Moreover, the preferred compounds exhibit good absorption and good blood-brain distribution when administered orally.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: October 17, 2023
    Assignee: Gan & Lee Pharmaceuticals
    Inventors: Lei Yin, Wenjian Liu, Heng Li, Dianxi Zhu
  • Publication number: 20220223429
    Abstract: N-polar transistor structures have relied on the use of dry etch processes that use plasmas generated from gaseous species to remove III-N layers as commercially viable wet etchants do not exist. The present disclosure reports on methods for the fabrication of N-polar III-N transistors using wet etches along with transistor structures that are enabled by the availability of wet-etches.
    Type: Application
    Filed: June 18, 2021
    Publication date: July 14, 2022
    Applicant: The Regents of the University of California
    Inventors: Brian Romanczyk, Emmanuel Kayede, Wenjian Liu, Islam Sayed, Umesh K. Mishra
  • Publication number: 20210371418
    Abstract: The embodiments disclosed herein provide compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, or a pharmaceutically acceptable salt or solvate of the compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, wherein R1 to R7 are as defined in the description. This application also provides a preparation method and a medical use of the compounds. The compounds of this disclosure have an activity superior or equivalent to the candidate drug LY2835219 currently under phase III clinical trial, and some of the compounds exhibit better selectivity. Moreover, the preferred compounds exhibit good absorption and good blood-brain distribution when administered orally.
    Type: Application
    Filed: July 30, 2021
    Publication date: December 2, 2021
    Inventors: Lei Yin, Wenjian Liu, Heng Li, Dianxi Zhu
  • Patent number: 11118675
    Abstract: A method for controlling gear shifting, including: acquiring a current gear-shifting parameter of the vehicle (101); according to the current gear-shifting parameter and a preset target rotational speed, determining a gear-shifting inputted rotational speed (102); and when a rotational speed of the vehicle reaches the gear-shifting inputted rotational speed, controlling a shifting fork to start up a gear-shifting operation (103). The method for controlling gear shifting presets the target rotational speed of the gears, and, according to the current gear-shifting parameter of the vehicle that is acquired in real time and the preset target rotational speed, inversely calculates the gear-shifting inputted rotational speed, whereby the gear-shifting inputted rotational speed is an accurate gear-shifting inputted rotational speed that matches with the current condition of the vehicle.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: September 14, 2021
    Assignee: GREAT WALL MOTOR COMPANY LIMITED
    Inventors: Zhiyuan Shen, Philip-Thomas Harris, Haoyong Lv, Peng Jia, Wenjian Liu
  • Patent number: 11091476
    Abstract: The embodiments disclosed herein provide compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, or a pharmaceutically acceptable salt or solvate of the compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, wherein R1 to R7 are as defined in the description. This application also provides a preparation method and a medical use of the compounds. The compounds of this disclosure have an activity superior or equivalent to the candidate drug LY2835219 currently under phase III clinical trial, and some of the compounds exhibit better selectivity. Moreover, the preferred compounds exhibit good absorption and good blood-brain distribution when administered orally.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: August 17, 2021
    Assignee: Gan & Lee Pharmaceuticals
    Inventors: Lei Yin, Wenjian Liu, Heng Li, Dianxi Zhu
  • Publication number: 20210215246
    Abstract: A method for controlling gear shifting, including: acquiring a current gear-shifting parameter of the vehicle (101); according to the current gear-shifting parameter and a preset target rotational speed, determining a gear-shifting inputted rotational speed (102); and when a rotational speed of the vehicle reaches the gear-shifting inputted rotational speed, controlling a shifting fork to start up a gear-shifting operation (103). The method for controlling gear shifting presets the target rotational speed of the gears, and, according to the current gear-shifting parameter of the vehicle that is acquired in real time and the preset target rotational speed, inversely calculates the gear-shifting inputted rotational speed, whereby the gear-shifting inputted rotational speed is an accurate gear-shifting inputted rotational speed that matches with the current condition of the vehicle.
    Type: Application
    Filed: May 31, 2019
    Publication date: July 15, 2021
    Applicant: GREAT WALL MOTOR COMPANY LIMITED
    Inventors: Zhiyuan SHEN, Philip·Thomas HARRIS, Haoyong LV, Peng JIA, Wenjian LIU
  • Patent number: 11028887
    Abstract: A method and apparatus for correcting a physical slip and wear coefficient of a clutch comprising obtaining a torque difference according to a positional relation between an engine and the clutch; obtaining a correction weight value corresponding to an engine torque according to the torque difference; and correcting the physical slip and wear coefficient according to the correction weight value and a running-in state of the clutch. The method relates to obtaining a torque difference in real time by means of a positional relation between the engine and the clutch in a manner corresponding to the positional relation, obtaining a correction weight value corresponding to the engine torque according to the torque difference, and further correcting the physical slip and wear coefficient by combining the correction weight value and a running-in state of the clutch.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: June 8, 2021
    Assignee: GREAT WALL MOTOR COMPANY LIMITED
    Inventors: Zhitao Hu, Antonius Johannes Ma Van De Ven, Xiaodong Liu, Wenjian Liu
  • Publication number: 20200378454
    Abstract: A method and apparatus for correcting a physical slip and wear coefficient of a clutch comprising obtaining a torque difference according to a positional relation between an engine and the clutch; obtaining a correction weight value corresponding to an engine torque according to the torque difference; and correcting the physical slip and wear coefficient according to the correction weight value and a running-in state of the clutch. The method relates to obtaining a torque difference in real time by means of a positional relation between the engine and the clutch in a manner corresponding to the positional relation, obtaining a correction weight value corresponding to the engine torque according to the torque difference, and further correcting the physical slip and wear coefficient by combining the correction weight value and a running-in state of the clutch.
    Type: Application
    Filed: January 30, 2019
    Publication date: December 3, 2020
    Applicant: GREAT WALL MOTOR COMPANY LIMITED
    Inventors: Zhitao HU, Antonius Johannes Ma VAN DE VEN, Xiaodong LIU, Wenjian LIU
  • Patent number: 10696678
    Abstract: The invention provides a compound of Formula I, or its tautomer, mesomer, racemate, enantiomer, diastereoisomer or a mixture thereof, or a pharmaceutically acceptable salt or solvate of the compound of Formula I, its tautomer, mesomer, racemate, enantiomer, or diastereoisomer. Ring A, R1, R2, R3 and R4 are as defined in the specification. The invention further provides a method for preparing the compound of Formula I and their use in the manufacture of a medicament for the treatment of a cell proliferative disorder.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: June 30, 2020
    Assignee: GAN & LEE PHARMACEUTICALS
    Inventors: Wenjian Liu, Lei Yin, Heng Li
  • Publication number: 20200165239
    Abstract: The embodiments disclosed herein provide compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, or a pharmaceutically acceptable salt or solvate of the compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, wherein R1 to R7 are as defined in the description. This application also provides a preparation method and a medical use of the compounds. The compounds of this disclosure have an activity superior or equivalent to the candidate drug LY2835219 currently under phase III clinical trial, and some of the compounds exhibit better selectivity. Moreover, the preferred compounds exhibit good absorption and good blood-brain distribution when administered orally.
    Type: Application
    Filed: November 28, 2016
    Publication date: May 28, 2020
    Inventors: Lei Yin, Wenjian Liu, Heng Li, Dianxi Zhu
  • Publication number: 20180305363
    Abstract: The invention provides a compound of Formula I, or its tautomer, mesomer, racemate, enantiomer, diastereoisomer or a mixture thereof, or a pharmaceutically acceptable salt or solvate of the compound of Formula I, its tautomer, mesomer, racemate, enantiomer, or diastereoisomer. Ring A, R1, R2, R3 and R4 are as defined in the specification. The invention further provides a method for preparing the compound of Formula I and their use in the manufacture of a medicament for the treatment of a cell proliferative disorder.
    Type: Application
    Filed: October 20, 2016
    Publication date: October 25, 2018
    Inventors: Wenjian Liu, Lei Yin, Heng Li
  • Patent number: 9868114
    Abstract: The method for preparing fluorine-doped lamellar black TiO2 nanomaterials includes mixing a solution of tetra-n-butyl titanate, n-propanol and hydrofluoric acid together, and then stir the solutions for a period of time. The solution is transferred into an autoclave and reacts at a certain temperature for a period of time. The sample obtained by the reaction is washed and dried. Then, the sample is heated in a protective atmosphere for a period of time so as to produce the fluorine-doped lamellar black TiO2 nanomaterials. This fluorine-doped lamellar black TiO2 owns superior optical absorption and electron transport performances.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: January 16, 2018
    Assignee: North China Electric Power University
    Inventors: Meicheng Li, Jiewei Chen, Yancong He, Bixia Xie, Wenjian Liu, Ruike Li
  • Publication number: 20170014811
    Abstract: The method for preparing fluorine-doped lamellar black TiO2 nanomaterials includes mixing a solution of tetra-n-butyl titanate, n-propanol and hydrofluoric acid together, and then stir the solutions for a period of time. The solution is transferred into an autoclave and reacts at a certain temperature for a period of time. The sample obtained by the reaction is washed and dried. Then, the sample is heated in a protective atmosphere for a period of time so as to produce the fluorine-doped lamellar black TiO2 nanomaterials. This fluorine-doped lamellar black TiO2 owns superior optical absorption and electron transport performances.
    Type: Application
    Filed: July 12, 2016
    Publication date: January 19, 2017
    Inventors: Meicheng LI, Jiewei CHEN, Yancong HE, Bixia XIE, Wenjian LIU, Ruike LI
  • Patent number: 8366841
    Abstract: A lead-free free-cutting corrosion-resistant silicon-bismuth brass alloy, including the following: between 60.0 and 65.0 wt % of Cu, between 0.6 and 1.8 wt % of Si, between 0.2 and 1.5 wt % of Bi, between 0.02 and 0.5 wt % of Al, less than 1.5 wt % of Ni+Mn+Sn, between 0.01 and 0.5 wt % of La—Ce alloy, between 0.002 and 0.02 wt % of B, with the remainder being Zn and inevitable impurities, wherein the total amount of impurities are no more than 0.5 wt %.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: February 5, 2013
    Assignees: Ningbo Xingaoda Advanced Metallic Materials Co., Ltd, Ningbo Aoda New Metal Materials Co., Ltd
    Inventors: Feng Peng, Baoping Xia, Jianping Liu, Bin Feng, Changshun Zheng, Wenjian Liu
  • Patent number: 8362023
    Abstract: Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of the compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer, Down syndrome or early onset Alzheimer's disease.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: January 29, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wenjian Liu, Kin-Chun Luk, Xiaohu Zhang
  • Publication number: 20120251382
    Abstract: A lead-free free-cutting corrosion-resistant silicon-bismuth brass alloy, including the following: between 60.0 and 65.0 wt % of Cu, between 0.6 and 1.8 wt % of Si, between 0.2 and 1.5 wt % of Bi, between 0.02 and 0.5 wt % of Al, less than 1.5 wt % of Ni+Mn+Sn, between 0.01 and 0.5 wt % of La—Ce alloy, between 0.002 and 0.02 wt % of B, with the remainder being Zn and inevitable impurities, wherein the total amount of impurities are no more than 0.5 wt %.
    Type: Application
    Filed: September 23, 2011
    Publication date: October 4, 2012
    Applicant: NINGBO XINGAODA ADVANCED METALLIC MATERIALS CO., LTD.
    Inventors: Feng Peng, Baoping Xia, Jianping Liu, Bin Feng, Changshun Zheng, Wenjian Liu
  • Publication number: 20120184508
    Abstract: Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer, Down syndrome or early onset Alzheimer's disease.
    Type: Application
    Filed: January 11, 2012
    Publication date: July 19, 2012
    Inventors: Wenjian Liu, Kin-Chun Luk, Xiaohu Zhang