Abstract: Systems and methods for generating motion plans including target trajectories for autonomous vehicles are provided. An autonomous vehicle may include or access a machine-learned motion planning model including a backbone network configured to generate a cost volume including data indicative of a cost associated with future locations of the autonomous vehicle. The cost volume can be generated from raw sensor data as part of motion planning for the autonomous vehicle. The backbone network can generate intermediate representations associated with object detections and objection predictions. The motion planning model can include a trajectory generator configured to evaluate one or more potential trajectories for the autonomous vehicle and to select a target trajectory based at least in part on the cost volume generate by the backbone network.

Abstract: Generally, the disclosed systems and methods utilize multi-task machine-learned models for object intention determination in autonomous driving applications. For example, a computing system can receive sensor data obtained relative to an autonomous vehicle and map data associated with a surrounding geographic environment of the autonomous vehicle. The sensor data and map data can be provided as input to a machine-learned intent model. The computing system can receive a jointly determined prediction from the machine-learned intent model for multiple outputs including at least one detection output indicative of one or more objects detected within the surrounding environment of the autonomous vehicle, a first corresponding forecasting output descriptive of a trajectory indicative of an expected path of the one or more objects towards a goal location, and/or a second corresponding forecasting output descriptive of a discrete behavior intention determined from a predefined group of possible behavior intentions.

Abstract: Treatment of neurodegenerative diseases is achieved using small molecule purine scaffold compounds that inhibit Hsp90 and that possess the ability to cross the blood-brain barrier or are other wise delivered to the brain.

Abstract: Systems, methods, tangible non-transitory computer-readable media, and devices for object detection, tracking, and motion prediction are provided. For example, the disclosed technology can include receiving sensor data including information based on sensor outputs associated with detection of objects in an environment over one or more time intervals by one or more sensors. The operations can include generating, based on the sensor data, an input representation of the objects. The input representation can include a temporal dimension and spatial dimensions. The operations can include determining, based on the input representation and a machine-learned model, detected object classes of the objects, locations of the objects over the one or more time intervals, or predicted paths of the objects. Furthermore, the operations can include generating, based on the input representation and the machine-learned model, an output including bounding shapes corresponding to the objects.

Abstract: Systems, methods, tangible non-transitory computer-readable media, and devices for object detection are provided. For example, sensor data associated with objects can be received. Segments encompassing areas associated with the objects can be generated based on the sensor data and a machine-learned model. A position, a shape, and an orientation of each of the objects in each of the one or more segments can be determined over a plurality of time intervals. Further, a predicted position, a predicted shape, and a predicted orientation of each of the objects at a last one of the plurality of time intervals can be determined. Furthermore, an output based at least in part on the predicted position, the predicted shape, or the predicted orientation of each of the one or more objects at the last one of the plurality of time intervals can be generated.

Abstract: Systems and methods for performing semantic segmentation of three-dimensional data are provided. In one example embodiment, a computing system can be configured to obtain sensor data including three-dimensional data associated with an environment. The three-dimensional data can include a plurality of points and can be associated with one or more times. The computing system can be configured to determine data indicative of a two-dimensional voxel representation associated with the environment based at least in part on the three-dimensional data. The computing system can be configured to determine a classification for each point of the plurality of points within the three-dimensional data based at least in part on the two-dimensional voxel representation associated with the environment and a machine-learned semantic segmentation model. The computing system can be configured to initiate one or more actions based at least in part on the per-point classifications.

Abstract: The invention provides a previously uncharacterized protein (gamma secretase activating protein or gSAP) that activates ?-secretase to produce ?-amyloid protein (A?). Deposition of A? has been associated with Alzheimer's disease and other pathologies. The invention thus additionally provides, e.g., screening methods and novel research tools, inhibitors of this novel protein, and methods of diagnosis, treatment and control of Alzheimer's disease and other neurodegenerative conditions associated with deposition of A?.

Abstract: The invention provides a previously uncharacterized protein (gamma secretase activating protein or gSAP) that activates ?-secretase to produce ?-amyloid protein (A?). Deposition of A? has been associated with Alzheimer's disease and other pathologies. The invention thus additionally provides, e.g., screening methods and novel research tools, inhibitors of this novel protein, and methods of diagnosis, treatment and control of Alzheimer's disease and other neurodegenerative conditions associated with deposition of A?.

Abstract: Treatment of neurodegenerative diseases is achieved using small molecule purine scaffold compounds that inhibit Hsp90 and that possess the ability to cross the blood-brain barrier or are other wise delivered to the brain.