Patents by Inventor Wenjie RNE

Wenjie RNE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHO CELL LINE, CONSTRUCTION THEREOF AND RECOMBINANT PROTEIN EXPRESSION SYSTEM USING CHO CELL LINE
    Publication number: 20210292783
    Abstract: The disclosure relates to genetic engineering, and more particularly to a CHO cell line, its construction and a recombinant protein expression system using the CHO cell line. Regardless of the presence screening pressure, the recombinant protein expression system constructed by the 60th passage of the recombinant APRT gene-deficient CHO cell line is much higher than the normal recombinant CHO cell in the expression retention of the target protein EGFP. In the absence of G418 screening pressure, the expression level of the recombinant vitronectin in the recombinant protein expression system constructed by the 30th passage of the recombinant APRT gene-deficient CHO cell is significantly higher than the expression level of the corresponding target protein in the normal recombinant CHO cells.
    Type: Application
    Filed: July 23, 2020
    Publication date: September 23, 2021
    Inventors: Tianyun WANG, Wenjie RNE, Yanlong JIA, Jiangtao LU, Tianjun NI, Xiaoyin WANG, Xiao GUO, Yan LIN, Chong WANG