Abstract: Embodiments of the present disclosure provide systems and methods for implementing self-bias detection based on performance and importance. A disclosed computer implemented method aggregates continuous input data through a K-means clustering algorithm to reduce the number of aggregated sub-group data pairs, enabling a reduced calculation time for computing bias and enhanced performance. The self-bias detection identifies a scale factor and a balance factor of aggregated sub-group data pairs, which indicate the importance of the detected bias.

Abstract: Embodiments of the present disclosure provide systems and methods for implementing self-bias detection based on performance and importance. A disclosed computer implemented method aggregates continuous input data through a K-means clustering algorithm to reduce the number of aggregated sub-group data pairs, enabling a reduced calculation time for computing bias and enhanced performance. The self-bias detection identifies a scale factor and a balance factor of aggregated sub-group data pairs, which indicate the importance of the detected bias.

Abstract: A dispensing system includes a liquid storage box having a liquid storage cavity and a liquid outlet in communication with the liquid storage cavity, and a liquid mixing box having a liquid mixing cavity and a liquid inlet and a mixed liquid outlet that are in communication with the liquid mixing cavity. The liquid mixing box includes a visible region through which the liquid mixing cavity is observable. The dispensing system further includes a dispensing device connected to the liquid outlet and the liquid inlet. The dispensing device is configured to deliver a detergent in the liquid storage cavity to the liquid mixing cavity.

Abstract: The present application relates to a synthesis method for cariprazine, comprising performing an acylation reaction between a compound represented by formula (I) and dimethylcarbamoyl chloride in a reaction solvent in the presence of an aqueous solution of an inorganic base, so as to obtain the cariprazine compound represented by formula (II). The synthesis method overcomes defects in the prior art such as a long reaction time, large size impurities and the difficulty of purification, and provides a new method suitable for commercial production wherein the reaction is fast, impurity sizes are small, the product is easily purified, the purity of the product can reach 99.0% or more, and the yield is high.

Abstract: The present application relates to a synthesis method for cariprazine, comprising performing an acylation reaction between a compound represented by formula (I) and dimethylcarbamoyl chloride in a reaction solvent in the presence of an aqueous solution of an inorganic base, so as to obtain the cariprazine compound represented by formula (II). The synthesis method overcomes defects in the prior art such as a long reaction time, large size impurities and the difficulty of purification, and provides a new method suitable for commercial production wherein the reaction is fast, impurity sizes are small, the product is easily purified, the purity of the product can reach 99.0% or more, and the yield is high.

Abstract: The present disclosure provides a household appliance and a control assembly which includes a control panel, a display screen and a power switch. The display screen is arranged on the control panel and can move relative to the control panel. The power switch is connected to the control panel and/or the display screen for controlling the power-on and power-off of the household appliance. When the display screen is pressed, the display screen moves relative to the control panel and controls the power-on or power-off of the power switch. By pressing the display screen to control the power-on and power-off of the power switch, a complete power-off can be achieved to eliminate the drawbacks of weak power and incomplete power-off of the touch-sensitive power switch, and the arrangement of a power switch key is omitted, therefore the operation and the overall appearance of the household appliance is simplified.

Abstract: The present disclosure provides a household appliance and a control assembly which includes a control panel, a display screen and a power switch. The display screen is arranged on the control panel and can move relative to the control panel. The power switch is connected to the control panel and/or the display screen for controlling the power-on and power-off of the household appliance. When the display screen is pressed, the display screen moves relative to the control panel and controls the power-on or power-off of the power switch. By pressing the display screen to control the power-on and power-off of the power switch, a complete power-off can be achieved to eliminate the drawbacks of weak power and incomplete power-off of the touch-sensitive power switch, and the arrangement of a power switch key is omitted, therefore the operation and the overall appearance of the household appliance is simplified.

Abstract: Provide in the present invention is a method for preparing canagliflozin intermediate 2-(2-methyl-5-bromobenzyl)-5-(4-fluorophenyl)thiophene. The method comprises a compound, shown as formula (II), of (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]ketone being reduced under the action of a directly used borane solution or borane locally produced by reacting alkali metal borohydride with a Lewis acid in a suitable solvent and at a suitable temperature, so as to obtain the compound of formula (I) of 2-(2-methyl-5-bromobenzyl)-5-(4-fluorophenyl)thiophene. The preparation method avoids the use of expensive reductive agents and guarantees the complete conversion of raw materials, wherein the post-treatment is simple, the purity of product obtained is high, the reaction yield is high, in the preparation method is simple and convenient, and can easily be used in industry.

Abstract: Provide in the present invention is a method for preparing canagliflozin intermediate 2-(2-methyl-5-bromobenzyl)-5-(4-fluorobenzene)thiophene. The method comprises a compound, shown as formula (II), of (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]ketone being reduced under the action of a directly used borane solution or borane locally produced by reacting alkali metal borohydride with a Lewis acid in a suitable solvent and at a suitable temperature, so as to obtain the compound of formula (I) of 2-(2-methyl-5-bromobenzyl)-5-(4-fluorobenzene)thiophene. The preparation method avoids the use of expensive reductive agents and guarantees the complete conversion of raw materials, wherein the post-treatment is simple, the purity of product obtained is high, the reaction yield is high, in the preparation method is simple and convenient, and can easily be used in industry.